Simultaneous laparoscopic treatment for rectosigmoid and ileal endometriosis.

Endometriosis is common in women of childbearing age, while severe intestinal endometriosis requiring bowel resection is relatively rare. Intestinal endometriosis has recently been managed laparoscopically. We report the case of a 38-year-old patient with rectosigmoid and ileal endometriosis who was successfully treated by laparoscopic bowel resections.

[Correlation between enzymatic activity and gene expression of orotate phosphoribosyl transferase (OPRT) in colorectal cancer].

Background: Orotate phosphoribosyl transferase (OPRT) is the initial key enzyme in the 5-FU metabolic pathway. It is an enzyme that converts 5-fluorouracil into 5-fluorouridine monophosphate. We have previously shown that there is a strong positive correlation between OPRT activity and the antitumor effects of 5-FU.