Publications by authors named "Suckwon Lee"
The synthetic Notch receptor (synNotch) system is a versatile platform that induces gene transcription in response to extracellular signals. However, its application has been largely confined to membrane-bound targets due to specific activation requirements. Whether synNotch can also target extracellular protein aggregates, such as amyloid beta (Aβ) in Alzheimer's disease (AD), is unclear.
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- Cellular senescence, which causes irreversible cell cycle arrest, plays a role in tumor suppression and accumulates with age, leading to the secretion of factors known as the 'senescence-associated secretory phenotype' (SASP) that can influence health both positively and negatively.
- Recent research shows that senescent cells also exist in the brain and may contribute to neuronal loss in age-related neurodegenerative diseases, prompting interest in using senolytics—drugs that target and eliminate these senescent cells.
- The review examines the effectiveness and mechanisms of various senolytics in mouse models, their potential side effects, and alternatives to reduce risks while promoting cognitive health.