[Experience gained with the training of interns-hygienists and its use in creating the structure of an integrated licensing examination "Step 3 - Sanitary-Hygienist Work"].

The experience gained with the training of interns-hygienists at the National Medical University has proved its value, contributing to which fact were modern material-and-technical resources, close cooperation of chairs of hygiene with sanitary epidemiologic stations and scientific-research institutes, highly skilled scientific and teaching personnel, systematic sharing of experience gained in training of specialists with institutions of higher learning of Ukraine. However, interns, Masters, practitioners are still in great need of modern educational literature/training aids. There has not yet been developed a general concept of structure of sanitary epidemiological service of Ukraine, forms and methods of its work under present-day conditions.

[The environment and health status of Ukraine's population before and after the Chernobyl AES accident].

Qualitative and quantitative analyses of the environment and human health during 5 years before and after the Chernobyl accident (1986) provided an original scheme and methods for hygienic assessment of the negative influence of environmental pollution on health. They were tested in the Kiev Region. The accident was found to essentially complicated the environmental and sanitary situation in the region and to negatively affect human health.

[Role of trace elements in the development of chronic ischemic heart disease].

It was shown that determination of erythrocyte superoxide dismutase activity proves to be the adequate test of antioxidant protection under chronic coronary heart disease as well as the reliable laboratory test for the control of the effect of prophylactic ultra-violet radiation.

[Metabolism in experimental chronic ischemic heart disease].

An increase in frequency of heart contractions, changes in the bioelectrical heart activity and decrease of the force-pump heart function are observed in the rabbits with model chronic ischemic heart disease lipid metabolism in significantly changed the concentration of cholesterol in the right ventricle myocardium as well as the concentrations of unsaturated lipid acids in the heart tissues increase, while the content of saturated lipid acids and antioxidant activity of plasma decrease. Bioenergetic processes change as follows: succinate-dehydrogenase and alpha-keto-glutarate-dehydrogenase activity decrease, while the concentrations of glycogen, lactic and pyruvic acids and lactate dehydrogenase activity in the heart tissues increase.

[The relation between oxidative processes and the glycogen content in the heart and liver of rabbits with chronic ischemic heart disease].

While laboratory experimental model of coronary heart disease (according to Frol'kis et al.) is developed, activity of succinate dehydrogenase, alpha-ketoglutarate dehydrogenase, Na+, Ka(+)- and Mg2+ ATPase decreases, but activity of lactate dehydrogenase and concentrations of lactic and pyruvic acids in the heart tissue increase. At the same time concentration of glycogene increases more than twice.

[The effect of ultraviolet irradiation on the cesium-137 and strontium-90 levels in the body of laboratory animals].

A 10-day course of ultraviolet radiation (intensity: 1/8-2 biodoses daily) did not favour accumulation of cesium-137 in the body but produced some effect on the accumulation of strontium-90. In the real radiation condition in the city of Kiev the daily prophylactic 1/8 biodose may be considered as absolutely safe.

[Effect of ultraviolet irradiation on calcium, sodium and potassium levels in albino rats].

Data presented by the authors testifies to the fact that neither 2 weeks, nor one month after the 10-day course of ultraviolet irradiation (UVR) with an intensity from 1/4 up to 2 biodoses daily changes in calcium, sodium and potassium content in blood serum of laboratory animals (white rats) were detected. At the same time, 2 weeks following the cessation of UVR course a tendency towards calcium accumulation in the whole organism of laboratory animals was observed, which was most noticeable+ after daily 10-day exposure to UVR with an intensity from 1/2 up to 1 biodose. The tendency was still present one month following the termination of UVR course.

[The biochemical role of selenium in animal orgamisms].

Data on the biochemical function of selenium in animal and human organism are generalized from the view point of its participation in the active centre of glutathione peroxidase and its general anabolic effect. Now it is assumed that many chronical human diseases such as cancer, cardiovascular insufficiency, atherosclerosis, pancreas insufficiency and other may be connected with selenium deficiency in human nutrition. A problem is considered on ecological and endogenous factors controlling the availability of selenium in animals.

[Histopathomorphologic changes in the organs and tissues of laboratory animals receiving an artificial diet with a low selenium and vitamin E content].

The deficiency of selenium and vitamin "E" is not infrequently noted to occur in agricultural and game-animals. Its development in humans is not ruled out. Experiments set up on mice of the CC57 lineage fed on an artificial ration with a low selenium and vitamin "E" content showed an acute selenium and vitamin "E" deficit apt to call forth profound histopathomorphological changes that become apparent following hematoxylin-eosin staining in the pancreas, liver, heart, kidneys, testes and muscular tissue.