Discovery of Ring-Annulated Analogues of Cannabidiol as Potential Anticancer Agents: Synthesis and Biological Evaluation.

Cannabidiol (CBD) is a nonpsychoactive cannabinoid derived from and its potential therapeutic effects extend beyond its well-known antiepileptic properties. Exploring CBD and its analogues as anticancer agents has gained significant attention in recent years. In this study, a series of novel ring-annulated analogues of CBD with oxazinyl moiety were synthesized and evaluated for their antiproliferative effect.

Unprecedented Haemorrhagic Stroke: A Rare Manifestation of Atypical Haemolytic Syndrome.

Atypical haemolytic uraemic syndrome (aHUS) is a rare and complex condition characterized by systemic thrombotic microangiopathy resulting from complement dysregulation. While primarily affecting renal microvasculature, aHUS can present with multi-organ involvement, posing significant diagnostic and therapeutic challenges. We report the case of a 22-year-old female with a history of aHUS who developed a catastrophic haemorrhagic stroke.

Impact of COVID-19 pandemic on the elderly in the United Kingdom: A review study.

The coronavirus disease 2019 (COVID-19) pandemic has significantly altered the lives and lifestyles of several older populations in the United Kingdom. It was important to note how it has affected their physical, mental, and social health and well-being during the first wave of the Covid-19 pandemic. To study the impact of the Covid-19 pandemic and the imposed restrictions on the day-to-day lives of the elderly population in the United Kingdom.

Selenium treatment alters the accumulation of osmolytes in arsenic-stressed rice (Oryza sativa L.).

Arsenic (As), one of the major pollutants in the soil, is an important environmental concern as its consumption can cause adverse health symptoms in living organisms. Its contamination of rice grown over As-contaminated areas is a serious concern in South Asian countries. Selenium (Se) has been reported to influence various osmolytes under metal stress in plants.

Interactive effects of selenium and arsenic on phenolic constituents and antioxidant activity in rice (Oryza sativa L.).

Arsenic (As) is a heavy toxic metalloid found in air, water and soil that adversely affects the plant growth by inducing oxidative stress in plants. Its contamination of rice is a serious problem throughout the world. Selenium (Se) is a beneficial micronutrient for plants that acts as an antioxidant at low doses and protect the plants against number of environmental stresses either by modulating the primary metabolic pathways or regulating the production of phenolic compounds.

Exploring the molecular basis of resistance to in chickpea genotypes through biochemical and morphological markers.

Chickpea ( L.) is an important pulse crop around the globe and a valuable source of protein in the human diet. However, it is highly susceptible to various plant pathogens such as fungi, bacteria, and viruses, which can cause significant damage from the seedling phase until harvest, leading to reduced yields and affecting its production.

Morphological, ultrastructural and molecular variations in susceptible and resistant genotypes of chickpea infected with Botrytis grey mould.

Biotic stress due to fungal infection is detrimental to the growth and development of chickpea. In our study, two chickpea genotypes (resistant) and PBG5 (susceptible) were inoculated with (1 × 10 spore mL) of nectrotrophic fungus at seedling stage. These seedlings were evaluated for morphological, ultrastructural, and molecular differences after 3, 5 and 7 days post inoculation (dpi).

Terahertz radiation detection with a cantilever-based photoacoustic sensor.

We report the photoacoustic (PA) response in the terahertz (THz) range by employing a detection process actuated with a silicon cantilever pressure sensor and a carbon-based radiation absorber. The detection relies on the mechanical response of the cantilever, when the volume of the carrier gas inside the PA cell expands with the heat produced by the radiation absorber. The detector interferometrically monitors the movement of the cantilever sensor to generate the PA signal.

Vulnerability for Respiratory Infections in Asthma Patients: A Systematic Review.

Asthma is a non-communicable and long-term condition affecting children and adults. The air passages in the lungs become narrow due to inflammation and tightening of the muscles around the small airways. Symptoms of asthma are intermittent and include cough, wheeze, shortness of breath, and chest tightness.

Devastating salt-wasting crisis in a four-month-old male child with congenital adrenal hyperplasia, highlighting the essence of neonatal screening.

Congenital adrenal hyperplasia (CAH) is a rare condition usually referred to as a group of genetic disorders resulting due to a deficiency of steroid enzymes required by adrenal glands to produce cortisol and mineralocorticoid hormones. It has an autosomal recessive mode of inheritance and is further categorized into two types-Classic and Non-Classic. Non-Classic CAH is a more common milder form that presents late after puberty.

Nanocomposite of MgFeO and MnO as Polyphenol Oxidase Mimic for Sensing of Polyphenols.

Polyphenol oxidase (PPO) mimics have advantage of detection and remediation of polyphenols. This work demonstrates rapid and sensitive colorimetric detection of phenolic compounds using nanocomposite of magnesium ferrite (MgFeO) and manganese oxide (MnO) nanoparticles as PPO mimic. The catalytic properties of MgFeO and MnO displayed synergistic effect in the nanocomposite.

Selenium alleviates physiological traits, nutrient uptake and nitrogen metabolism in rice under arsenate stress.

A green house experiment was conducted to evaluate the efficacy of soil application of selenium (Se) in modulating metabolic changes in rice under arsenic (As) stress. Rice plants were grown over soil amended with sodium arsenate (25, 50 and 100 μM kg soil) with or without sodium selenate @ 0.5 and 1 mg kg soil in a complete randomized experimental design, and photosynthetic efficiency, nutrient uptake and nitrogen metabolism in rice leaves were estimated at tillering and grain filling stages.

Optical power detector with broad spectral coverage, high detectivity, and large dynamic range.

Optical power measurements are needed in practically all technologies based on light. Here, we report a general-purpose optical power detector based on the photoacoustic effect. Optical power incident on the detector's black absorber produces an acoustic signal, which is further converted into an electrical signal using a silicon-cantilever pressure transducer.

Evaluation of Serum Electrolyte Levels in Patients With Anemia.

Introduction: Anemia is one of the most prevalent diseases globally. Various diseases have linked anemia with electrolyte disturbance. However, the local data are limited.

Gastrointestinal Manifestation of COVID-19 in Hospitalized Patients.

Introduction: During the initial phase of the pandemic, gastrointestinal (GI) symptoms were less frequent but during the later stages, GI manifestations have become more frequent. This study aims to explore the prevalence of GI symptoms in COVID-19 patients, and also focuses on the frequency of these symptoms.

Methods: This longitudinal study was conducted in a COVID-19 unit of a tertiary care hospital, Pakistan.

Sleep Quality in the Indian Adult Population During the COVID-19 Pandemic.

Background: In response to the COVID-19 pandemic, social distancing measures such as stay-at-home orders were implemented for all non-essential workers. The consequent disruption in the defined daily work routine has impacted both the quality and duration of sleep. Our aim was to evaluate the quality of sleep in the Indian adult population during the COVID-19 pandemic.

Gambling behaviors during COVID-19: a narrative review.

The COVID-19 pandemic has ushered the world into unforeseen circumstances, prompting the authorities to impose restrictions and cut back various events including many gambling avenues. Professional sports have been postponed, land casinos are closed, and social distancing has shut home games down. The present narrative overview has addressed the following changes in gambling behavior since the start of the pandemic: - a) Change in the number of gamblers and intensity of gambling b) differences among various types of gambling modalities (land-based, horse betting, casino, online).

Fracture Nonunions and Delayed Unions Treated With Low-Intensity Pulsed Ultrasound Therapy: A Clinical Series.

The incidence of nonunion of fractures has been steadily rising owing to improved life expectancy following severe injuries along with rising cases of polytrauma. Once a nonunion is established, the chances of spontaneous healing are deemed to be quite low. Fracture nonunion continues to be a challenge in clinical practice with nonunions having a considerable impact on patient's quality of life causing both functional and psychosocial disability.

Photoacoustic characteristics of carbon-based infrared absorbers.

We present an experimental comparison of photoacoustic responsivities of common highly absorbing carbon-based materials. The comparison was carried out with parameters relevant for photoacoustic power detectors and Fourier-transform infrared (FTIR) spectroscopy: we covered a broad wavelength range from the visible red to far infrared (633 nm to 25 μm) and the regime of low acoustic frequencies (< 1 kHz). The investigated materials include a candle soot-based coating, a black paint coating and two different carbon nanotube coatings.

Influence of selenite and selenate on growth, leaf physiology and antioxidant defense system in wheat (Triticum aestivum L.).

Background: Selenium (Se) induced oxidative stress as well as synthesis of non-specific selenoproteins has been attributed to its toxicity in plants. Selenium toxicity can affect growth, chlorophyll and protein synthesis and crop yield. This study reveals the effects of different sources (sodium selenite and sodium selenate) and levels (2 and 4 mg Se kg soil) of Se on its uptake, leaf physiology, antioxidant defense system, isoenzymic patterns and mitochondrial activity in wheat cultivar PBW621 at tillering and ear-initiation stages.

Electro optic sensor for high precision absolute distance measurement using multiwavelength interferometry.

A prototype multi-wavelength interferometric, phase shifting distance sensor based on linear electro optic effect has been demonstrated in this work to improve the measurement speed of a commercial four-wavelength interferometer. Experimental results revealed the phase modulation ability of the sensor, preserving equivalent efficiency for nanometer-scale absolute distance measurement similar to present piezoelectricity driven mechanical phase modulation. The electro optic sensor working under free beam propagation can significantly overcome the limitations experienced by mechanical phase modulation technique such as the restricted value for the modulating frequency and as well the high driving voltage requirement.

Physical characteristics and nutritional composition of some new soybean (Glycine max (L.) Merrill) genotypes.

Soybean is a major source of high quality protein and oil and soybean seed quality is often determined by seed nutritional and antinutritional parameters. The objective of this study was to investigate the physical characteristics and nutritional composition of some new soybean genotypes. Hundred seed weight and volume of soybean genotypes ranged from 8.

Positional effects on soybean seed composition during storage.

This investigation was conducted in order to determine the degree of biochemical changes during natural ageing of soybean seeds borne on different positions on stem axis. Biochemical analysis of field grown soybean seeds revealed significant differences in their oil and protein contents as a function of nodal positions. Both oil and protein content decreased after 180 days of storage (DOS) at all the nodal positions.

Effect of sub-chronic selenium toxicosis on lipid peroxidation, glutathione redox cycle and antioxidant enzymes in calves.

The present investigation reports the effect of sodium selenite-induced sub-chronic toxicity in crossbred cow calves on various antioxidant enzymes. Sodium selenite (0.25 mg/kg for 16 w) resulted in characteristic signs of sub-chronic selenosis, ie alopecia, cracking and enlargement of hooves, interdigital lesions, ring formation on the coronet region, and gangrene at tip of the tail.