Publications by authors named "Subhas Chandra Aryal"
Prevalence of drug resistant Enterobacteriaceae in a Nepalese tertiary care hospital.
PLOS Glob Public Health
January 2024
Article Synopsis
- Antimicrobial resistance in Enterobacteriaceae is a growing global concern, with a study in Nepal revealing high rates of antibiotic resistance among bacteria found in clinical specimens.
- The study identified that 19.4% of isolates produced AmpC beta-lactamase, 29.6% produced extended spectrum beta-lactamase (ESBL), and 8.5% produced Metallo-beta-lactamase (MBL), with higher rates found in hospitalized patients compared to out-patients.
- The detection of resistant bacteria in out-patients without recent hospital visits suggests that drug-resistant Enterobacteriaceae are spreading in the community, highlighting the urgent need for strategies to combat antibiotic resistance.
Background And Objectives: Carbapenems have been the choice of antibiotics for the treatment of infections caused by multidrug-resistant bacteria. The main objective of this study was to determine the prevalence of carbapenemase ( and ) producing isolates among and
Materials And Methods: A total of 1,151 clinical samples were collected from the patients visiting Annapurna Neurological Institute and Allied Science and Annapurna Research Centre, Kathmandu, between June 2017 and January 2018. Antibiotic susceptibility testing (AST) was performed on the and isolates using the Kirby-Bauer disk diffusion method.
Background: Antibiotic resistance mediated by the production of extended-spectrum β-lactamases (ESBLs) and AmpC β-lactamases is posing a serious threat in the management of the infections caused by Gram-negative pathogens. The aim of this study was to determine the prevalence of two AmpC β-lactamases genes, and , in Gram-negative bacterial isolates.
Materials And Methods: A total of 1151 clinical samples were obtained and processed at the microbiology laboratory of Annapurna Neurological Institute and Allied Science, Kathmandu between June 2017 and January 2018.