Polymer modified magnetic-luminescent nanocomposites for combined optical imaging and magnetic fluid hyperthermia in cancer therapy: analysis of Mn doping for enhanced heating effect, hemocompatibility and biocompatibility.

Magnetic MnFeO nanoparticles and polymer coated magnetic-luminescent MnFeO@(Y,Dy/Eu)VO nanocomposites were prepared to study their comparative heat generation efficiency and biocompatibilities. Cubic crystalline phases were obtained for the nanoparticles and cubic-tetragonal biphasic phases were observed for the nanocomposites. The successful doping of Mn was also confirmed by inductively coupled plasma optical emission spectroscopy.

Vacancy-Induced Visible Light-Driven Fluorescence in Toxic Ion-Free Resorbable Magnetic Calcium Phosphates for Cell Imaging Applications.

Multifunctional nanosized particles are very beneficial in the field of biomedicine. Bioactive and highly biocompatible calcium phosphate (CaP) nanoparticles (∼50 nm) exhibiting both superparamagnetic and fluorescence properties were synthesized by incorporating dual ions (Fe and Sr) in HAp (hydroxyapatite) [Ca(PO)(OH)]. Insertion of Fe creates oxygen vacancies at the PO site, thereby destabilizing the structure.

Hypoxic Preconditioning Induces Neuronal Differentiation of Infrapatellar Fat Pad Stem Cells through Epigenetic Alteration.

Hypoxia is considered a key factor in cellular differentiation and proliferation, particularly during embryonic development; the process of early neurogenesis also occurs under hypoxic conditions. Apart from these developmental processes, hypoxia preconditioning or mild hypoxic sensitization develops resistance against ischemic stroke in deteriorating tissues. We therefore hypothesized that neurons resulting from hypoxia-regulated neuronal differentiation could be the best choice for treating brain ischemia, which contributes to neurodegeneration.

Thermally Modified Iron-Inserted Calcium Phosphate for Magnetic Hyperthermia in an Acceptable Alternating Magnetic Field.

Magnetic hyperthermia treatment using calcium phosphate nanoparticles is an evolutionary choice because of its excellent biocompatibility. In the present work, Fe is incorporated into HAp nanoparticles by thermal treatment at various temperatures. Induction heating was examined within the threshold H f value of 4.

An innovative bioresorbable gelatin based 3D scaffold that maintains the stemness of adipose tissue derived stem cells and the plasticity of differentiated neurons.

Neural tissue engineering aims at producing a simulated environment using a matrix that is suitable to grow specialized neurons/glial cells pertaining to CNS/PNS which replace damaged or lost tissues. The primary goal of this study is to design a compatible scaffold that supports the development of neural-lineage cells which aids in neural regeneration. The fabricated, freeze-dried scaffolds consisted of biocompatible, natural and synthetic polymers: gelatin and polyvinyl pyrrolidone.

Induction Heating Efficiency of Water-Dispersible MnFeO@YVO:Eu Magnetic-Luminescent Nanocomposites in an Acceptable ac Magnetic Field: Hemocompatibility and Cytotoxicity Studies.

Not many reports are available on magnetic-luminescent nanocomposites for cancer hyperthermia applications. Further, such nanocomposites on Mn-doped iron oxide may be available rather rarely. Studies on the induction heating properties within the threshold magnetic field and frequency factors are still rare.