Ligand-Mediated Exfoliation and Antibacterial Activity of 2H Transition-Metal Dichalcogenides.

Transition-metal dichalcogenides (TMDs) exists mainly in two polymorphs, namely, 1T (metallic) and 2H (semiconducting). To tailor the characteristics and practical utility of TMDs for different applications, functionalization is essential. In our earlier studies, we have shown that functionalized 1T and 2H MoS exhibit exceptionally high antibacterial activity.

Ligand Exchange on MoS Nanosheets: Applications in Array-Based Sensing and Drug Delivery.

Two-dimensional MoS nanosheets (2D-MoS) have been widely used in many biological applications due to their distinctive physicochemical properties. Further, the development of surface modification using thiolated ligands allows us to use them for many specific applications. But the effect of possible ligand exchange on 2D-MoS has never been explored, which can play an important role in diverse biological applications.

Dosimetry of pulsed magnetic field towards attaining bacteriostatic effect on Enterococcus faecalis: Implications for endodontic therapy.

Aim: To examine in a laboratory setting the efficacy of moderate to high strength magnetic fields, as a potential bacteriostatic stimulus, against Enterococcus faecalis, one of the causative agents for infection during root canal treatments.

Methodology: Four different strengths (1, 2, 3 and 4 T) of the pulsed magnetic field (PMF) were applied in thirty repetitions to bacterial suspension. A pickup coil setup was used to measure the electromotive force induced inside the bacterial suspensions.

Supramolecular Interaction of Molecular Cage and β-Galactosidase: Application in Enzymatic Inhibition, Drug Delivery and Antimicrobial Activity.

Enzyme inhibitors play a crucial role in diagnosis of a wide spectrum of diseases related to bacterial infections. We report here the effect of a water-soluble self-assembled Pd molecular cage towards β-galactosidase enzyme activity. The molecular cage is composed of a tetrapyridyl donor (L) and cis-[(en)Pd(NO ) ] (en=ethane-1,2-diamine) acceptor and it has a hydrophobic internal cavity.

Simultaneous Exfoliation and Functionalization of 2H-MoS by Thiolated Surfactants: Applications in Enhanced Antibacterial Activity.

Two-dimensional transition metal dichalcogenides (TMDs), such as MoS, generally exist in two different polymorphic structures, metallic (1T phase) and semiconducting (2H phase). In context of their wide spectrum of applications ranging from electronic to biomedicine, the aspects of ligand conjugation and solution processability are highly significant. In addition, the assessment of their antibacterial property and biocompatibility is equally important to explore their biomedical applications.

High Antibacterial Activity of Functionalized Chemically Exfoliated MoS.

In view of the implications of inherent resistance of pathogenic bacteria, especially ESKAPE pathogens toward most of the commercially available antibiotics and the importance of these bacteria-induced biofilm formation leading to chronic infection, it is important to develop new-generation synthetic materials with greater efficacy toward antibacterial property. In addressing this issue, this paper reports a proof-of-principle study to evaluate the potential of functionalized two-dimensional chemically exfoliated MoS (ce-MoS) toward inhibitory and bactericidal property against two representative ESKAPE pathogenic strain-a Gram-positive Staphylococcus aureus (MRSA) and a Gram-negative Pseudomonas aeruginosa. More significantly, the mechanistic study establishes a different extent of oxidative stress together with rapid membrane depolarization in contact with ce-MoS having ligands of varied charge and hydrophobicity.