Comparative study on cardiac autonomic modulation during deep breathing test and diaphragmatic breathing in type 2 diabetes and healthy subjects.

Aims/introduction: Diaphragmatic breathing is known to have a beneficial effect on the cardiopulmonary system, and enhances parasympathetic activation. We evaluated the influence of diaphragmatic breathing on time domain measures of heart rate variability in diabetics and healthy subjects.

Materials And Methods: A total of 122 type 2 diabetics and 94 healthy subjects (controls) were randomly allocated to a deep breathing test and diaphragmatic breathing (61 diabetics and 47 controls in each group).

Diaphragmatic breathing exercise as a therapeutic intervention for control of oxidative stress in type 2 diabetes mellitus.

Present study aims to evaluate the effect of diaphragmatic breathing on anthropometry, blood pressure, glycemic control and oxidative stress in patients with type 2 diabetes on standard care in comparison with standard care alone. Study involved 123 patients who were assigned to receive either standard care or with additional diaphragmatic breathing for 3 months. In comparison with the control group, diaphragmatic breathing resulted in significant reduction in body mass index, waist-hip ratio, fasting and post prandial plasma glucose, glycated hemoglobin, malondialdehyde, superoxide dismutase and improvement in glutathione and vitamin C.

Deterioration of cardiac autonomic function over a period of one year in relation to cardiovascular and somatic neuropathy complications in type 2 diabetes mellitus.

Aims: Progression of cardiac autonomic dysfunction (CADF) in relation to severity of diabetic autonomic neuropathy is well documented. But its progression while coexisting with somatic neuropathy (PNP) and cardiovascular disease (CVD) is less described. We monitored CADF over a period of one year in relation to PNP and CVD in patients with type 2 diabetes mellitus.

An experimental study of the anticonvulsant effect of amlodipine in mice.

Introduction: The need for the rational development of newer and adjuvant drugs to treat epilepsy has prompted this study of the potential anticonvulsant effect of amlodipine.

Methods: The acute effect was studied in mice in single doses of 1 mg/kg, 2 mg/kg and 4 mg/kg of amlodipine and the chronic effect was studied in doses of 1 mg/kg and 4 mg/kg (administered daily for 21 days) using the maximal electroshock seizure and pentylenetetrazole-induced seizure models of epilepsy. Sodium valproate and normal saline were used as the standard and control, respectively.

Influencing factors of QTc among the clinical characteristics in type 2 diabetes mellitus.

Aims: Although the clinical implications of prolonged Q-T interval have been described, the clinical determinants of Q-T interval in type 2 diabetes mellitus are not clear. We examined the influencing factors of QTc in type 2 diabetes mellitus.

Methods: This study involved 207 patients with type 2 diabetes mellitus and 141 healthy controls.

Impact of acute respiratory stress on cardiac autonomic control in young healthy subjects explored by time and frequency domain methods.

To find the possible utility of analysis of heart rate variability in quantifying transient cardiac autonomic modulation, we assessed the impact of breath holding-induced acute respiratory stress on heart rate variability parameters and blood pressure in young healthy subjects. In ten healthy subjects aged between 22-24 years of either sex, R-R intervals and blood pressure were recorded for one minute under resting state, during breath holding and immediately after withdrawal from breath holding. Heart rate variability was quantified by time and frequency domain methods.

Independent predictors of cardiac parasympathetic dysfunction in type 2 diabetes mellitus.

Introduction: Although the clinical implications of diabetic autonomic neuropathy have been described, the clinical determinants of parasympathetic dysfunction in type 2 diabetes mellitus are not clear. We investigated the clinical determinants of heart rate response to deep breathing in type 2 diabetes mellitus.

Methods: This study involved 207 randomly selected patients with type 2 diabetes mellitus and 141 healthy controls.