Midregional Proatrial Natriuretic Peptide (MRproANP) is associated with vertebral fractures and low bone density in patients with chronic obstructive pulmonary disease (COPD).

Background: Patients with COPD are often affected by loss of bone mineral density (BMD) and osteoporotic fractures. Natriuretic peptides (NP) are known as cardiac markers, but have also been linked to fragility-associated fractures in the elderly. As their functions include regulation of fluid and mineral balance, they also might affect bone metabolism, particularly in systemic disorders such as COPD.

Open-Source Biomedical Image Analysis Models: A Meta-Analysis and Continuous Survey.

Open-source research software has proven indispensable in modern biomedical image analysis. A multitude of open-source platforms drive image analysis pipelines and help disseminate novel analytical approaches and algorithms. Recent advances in machine learning allow for unprecedented improvement in these approaches.

Three-Dimensional Packing Defects in Lipid Membrane as a Function of Membrane Order.

Lipid membrane packing defects are considered to be an essential parameter that regulates specific membrane binding of several peripheral proteins. In the absence of direct experimental characterization, lipid packing defects and their role in the binding of peripheral proteins are generally investigated through computational studies, which have been immensely successful in unraveling the key steps of the membrane-binding process. However, packing defects are calculated using two-dimensional (2D) projections and the crucial information on their depths is generally overlooked.