Developing Augmented Pro-SOFA and Pro-SAPS Models by Integrating Biomarkers PCT, NLR, and CRP with SOFA and SAPS-III Scores.

Background: Sepsis, a life-threatening condition characterized by a dysregulated immune response to infection, remains a significant clinical challenge globally. This study aims to enhance the predictive accuracy of existing sepsis severity scores by developing augmented versions of the SOFA and SAPS-III models, termed Pro-SOFA and Pro-SAPS, through the integration of biomarkers procalcitonin (PCT), neutrophil-to-lymphocyte ratio (NLR), and C-reactive protein (CRP).

Methods: This prospective observational study was conducted in the medical ICU of a tertiary care hospital in southern India from August 2022 to December 2023.

Cerebral Hyperperfusion Syndrome following Staged Bilateral Internal Carotid Artery Stenting.

Cerebral Hyperperfusion syndrome is a relatively rare event following carotid revascularization. It can occur after both carotid endarterectomy and carotid artery stenting. It is characterized by focal neurodeficit, seizures and headache in the absence of ischemia.

Comparison of resting and adenosine-free pressure indices with adenosine-induced hyperemic fractional flow reserve in intermediate coronary lesions.

Objective: Fractional flow reserve (FFR) using adenosine has been the gold standard in the functional assessment of intermediate coronary stenoses in the catheterization laboratory. We aim to study the correlation of adenosine-free indices such as whole cycle Pd/Pa [the ratio of mean distal coronary pressure (Pd) to the mean pressure observed in the aorta (Pa)], instantaneous wave-free ratio (iFR), and contrast-induced submaximal hyperemia (cFFR) with FFR.

Methods: This multicenter, prospective, observational study included patients with stable angina or acute coronary syndrome (>48 h since onset) with discrete intermediate coronary lesions (40-70% diameter stenosis).

Large Scale Mapping of Fractures and Groundwater Pathways in Crystalline Hardrock By AEM.

In hardrocks that cover about 20% of the Earth's surface, it is difficult to locate steady sources for groundwater due to inadequate understanding of the fracture networks. A comprehensive knowledge of fracture distribution at the regional scale is necessary to delineate sustainable aquifers and manage them efficiently. The resistivity maps derived from the airborne electromagnetic (AEM) survey over the Ankasandra watershed in Karnataka, India, reveal sharp and deep zones of low formation resistivity, which indicate groundwater-bearing zones.

Transcatheter closure of ruptured sinus of Valsalva: Different techniques and mid-term follow-up.

Objectives: The aim of the present study was to study the feasibility and approaches to device closure of ruptured sinus of Valsalva (RSOV). We have compared the advantages and disadvantages of different devices and techniques and discussed complications which might occur during or after the procedure.

Background: There are only a few case series of transcatheter closure of RSOV, with most cases being traditionally referred for surgery.

Catastrophic presentation of anomalous origin of right pulmonary artery in a neonate--an interesting differential!

A 36-hour-old term neonate presented with refractory cardiogenic shock and multi-organ dysfunction. On suspecting coarctation of aorta, intravenous prostaglandin was started but without any benefit. Echocardiography revealed isolated anomalous origin of right pulmonary artery from ascending aorta causing massive aortic steal, supra-systemic pulmonary arterial hypertension (PAH), multi-organ dysfunction and right ventricular failure.

Source speciation resolving hydrochemical complexity of coastal aquifers.

There is a growing concern of seawater intrusion to freshwater aquifers due to groundwater overexploitation in the eastern coastal belt of Southern India. The problem becomes complex in the regions where industrial effluents are also contaminating the freshwater aquifers. In order to understand the hydrochemical complexity of the system, topographic elevation, static water level measurements, major ion chemistry, ionic cross plots, water type contours and factor analysis were applied for 144 groundwater samples of shallow and deep sources from Quaternary and Tertiary coastal aquifers, located within the industrial zone of 25 km(2) area near Cuddalore, Southern India.

Innovative endovascular technique for treatment of rare cause of haemoptysis in young.

A 17-year-old boy reported for evaluation of two episodes of massive haemoptysis. His clinical examination was unremarkable and investigations (haemogram, coagulogram, serological tests for connective tissue disorders) were normal. A 64-slice CT angiography revealed a saccular aneurysm of 3.

Percutaneous device closure of a bifurcated inferior vena cava and completion of the Kawashima procedure for the "difficult" univentricular heart.

Azygos continuation of inferior venacava (IVC) is well known in association with interrupted IVC. We report azygos connection of uninterrupted IVC in a young child with complex univentricular heart. This peculiar anatomy was made suitable for univentricular repair by combining percutaneous device closure of prehepatic right limb of IVC and bidirectional Glenn shunt.

"Transcollateral" renal angioplasty for a completely occluded renal artery.

Percutaneous transluminal renal angioplasty with stenting has been effective in the control of hypertension, renal function, and pulmonary edema caused by atherosclerotic renal artery stenosis. However, the role of the procedure has not been fully established in the context of chronic total occlusion of renal artery. We report the successful use of this procedure in 57-year-old male patient who reported for evaluation of a recent episode of accelerated hypertension.

Concise synthesis of omega-borono-alpha-amino acids.

A short protocol for the practical scale synthesis of several omega-borono-alpha-amino acids is described via the alkylation of benzophenone glycinimines with various electrophiles.

Non-surgical septal reduction for hypertrophic cardiomyopathy in childhood.

A case of non-surgical septal reduction (NSMR, NSRT) for hypertrophic cardiomyopathy (HCM) using absolute alcohol injection in a 3-year-old child is described. Septal ablation in children is controversial due to its unknown long-term consequence and arrythmogenic potential [1] [Denfield SW, Gajarski RJ, Towbin JA. Cardiomyopathies.

Studies towards the synthesis of epothilone A via organoboranes.

Studies towards the synthesis of epothilone A via organoboranes have been described. A modified procedure for the large-scale preparation of B-gamma,gamma-dimethylallyldiisopinocampheylborane from prenyl alcohol has been developed. This reagent, upon reaction with various aldehydes, provides the corresponding alpha,alpha-dimethylhomoallylic alcohols in high enantioselectivities.

Diastereoselective dihydroxylation and regioselective deoxygenation of dihydropyranones: a novel protocol for the stereoselective synthesis of C1-C8 and C15-C21 subunits of (+)-discodermolide.

Diastereoselective dihydroxylation of dihydropyranones and subsequent regioselective alpha-deoxygenation provides 1,3-trans-beta-hydroxy-delta-lactones stereoselectively. This protocol has been applied for the synthesis of C(1)-C(8) and C(15)-C(21) subunits of (+)-discodermolide.

Transcatheter closure of aortopulmonary window using Amplatzer device.

Two cases of transcatheter closure of aortopulmonary window (APW) using an Amplatzer duct occluder in one and a septal occluder device in the second are described. Transcatheter device closure of APW should be considered when anatomy is favorable in terms of location and size of the defect with absence of associated anomalies.

Stereoselective syntheses of (+)-goniodiol, (-)-8-epigoniodiol, and (+)-9-deoxygoniopypyrone via alkoxyallylboration and ring-closing metathesis.

A convenient synthesis of (+)-goniodiol, (-)-8-epigoniodiol, and (+)-9-deoxygoniopypyrone has been developed via asymmetric alkoxyallylboration and ring-closing metathesis pathways.