Publications by authors named "Subaraman Ramchandran"

Although neck injuries secondary to sporting activities in the pediatric demographic presenting to the emergency department (ED) are common, predictors of needing higher-level care (HLC) outside immediate treatment and release are not clear. The aim of this study was to describe how these neck injuries present in the United States (US) and identify predictors of HLC. We interrogated the US National Electronic Injury Surveillance System (NEISS) database for presentations to the ED of pediatric patients (aged 6-18 years old) whose primary complaint was neck injury in the setting of sport between 2014 and 2023.

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Article Synopsis
  • There is variability in the practice of obtaining whole-spine MRIs before surgery for adolescents with idiopathic scoliosis (AIS), prompting this study to evaluate the benefits of uniform MRI use.
  • The research included 283 asymptomatic AIS patients who had preoperative MRIs, revealing various neural axis anomalies in 9.9% of cases, with 2.1% requiring surgical intervention.
  • Findings indicated that although some patients had neuromonitoring alerts related to anomalies, none experienced permanent neurological deficits post-surgery, underscoring the importance of MRI in identifying potential complications.
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Introduction: Previous studies have shown that T1 tilt is positively correlated with post-operative shoulder balance (SB). The aim of this study was to explore the role of intra-operative T1 tilt, among other shoulder parameters as a potential parameter to predict post-operative SB in adolescent idiopathic scoliosis (AIS) patients.

Methods: A retrospective review of AIS patients with structural thoracic curves with minimum 2 year follow up was conducted from a single tertiary center.

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We report the use of computerized tomography (CT)-guided navigation for complex spinal deformity correction (anterior and posterior) in an 8-year-old patient with neurofibromatosis complicated by dystrophic pedicles, dural ectasia, and extensive vertebral scalloping. A retrospective review was conducted of the patient's medical records for the past 3 years, including the patient's office visit notes, operative reports, pre- and 2-year postoperative imaging studies. The patient successfully underwent anterior lumbar interbody fusion from L3-S1 using CT-guided navigation to negotiate the challenges posed by dural ectasia and vertebral body scalloping.

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Study Design: Retrospective case control study.

Objectives: To determine the role of TXA when used as topical soaked sponges (tTXA) on peri-operative blood loss and changes in hemoglobin following posterior spinal fusion (PSF) for neuromuscular and syndromic scoliosis (NMS).

Methods: A single center review of NMS patients who underwent PSF was conducted.

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Purpose: Utility of pre-operative MRI for patients undergoing scoliosis correction has expanded to include an MRI classification for identifying patients at increased risk of experiencing intra-operative neuromonitoring (IONM) alerts based on the shape of the spinal cord and circumferential presence of CSF at the apex of the thoracic curve. In the present study, the authors explore the utility of this new MRI classification and multiple X-ray radiographic parameters in identifying the AIS sub-population at high risk of IONM alerts.

Methods: AIS patients < 18 years old who underwent posterior spinal fusion between 2018 and 2022 at a single institution.

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Purpose: To evaluate the effectiveness of the use of topical tranexamic acid (tTXA) in spinal deformity correction in AIS patients METHODS: Sixty consecutive operative AIS patients were reviewed from a single institution and divided into two groups with similar demographics. Standardized peri-operative blood salvage techniques were utilized in all 60 patients. In the latter 30 patients, tTXA soaked sponges (1 g mixed in 500 ml Normal Saline) was utilised for wound packing during the entire surgical procedure compared to dry sponges as used in the former 30 patients.

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Article Synopsis
  • * A review of 20 patients revealed significant scoliosis corrections and low blood loss during surgery, with an average estimated blood loss of 307.9 mL and no intraoperative complications.
  • * Postoperative outcomes showed minor complications, but none were linked to the refusal of transfusion, suggesting that blood conservation strategies can be successfully implemented in this patient population.
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Study Design: Retrospective cohort study.

Objectives: The purpose of the study is to evaluate the role of supine radiographs in determining flexibility of thoracic and thoracolumbar curves.

Methods: Ninety operative AIS patients with 2-year follow-up from a single institution were queried and classified into MT structural and TL structural groups.

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Purpose: Late infection following posterior spinal fusion (PSF) for deformity is a leading cause of revision. The purpose of this study is to evaluate clinical and radiographic outcomes following a single-stage debridement and exchange of spinal implants with titanium in adolescent patients with late-onset infections following PSF METHODS: A retrospective review of prospectively collected data of adolescent patients with spinal deformity, who were surgically treated with PSF was collected. Patients were included for the study if they developed late arising infection (> 1 year after index posterior fusion for the deformity) from 2006-2019.

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Study Design: This study is a single-center retrospective radiographic review.

Objectives: The objective of this study is to evaluate a novel measurement parameter, mandibular slope (MS), as a measure of horizontal gaze.

Introduction: Assessment of sagittal spinal alignment is essential in the evaluation of spinal deformity patients.

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Study Design: Retrospective review of a prospectively collected database.

Objective: To define a simplified singular measure of cervical deformity (CD), C2 slope (C2S), which correlates with postoperative outcomes.

Summary Of Background Data: Sagittal malalignment of the cervical spine, defined by the cervical sagittal vertical axis (cSVA) has been associated with poor outcomes following surgical correction of the deformity.

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Article Synopsis
  • - The study is a retrospective review that examined how intraoperative measurements of the T1-pelvic angle (TPA), T4PA, and T9PA can predict global alignment after spinal surgery in adults with deformities.
  • - It involved 80 patients, showing that intraoperative angles significantly correlated with postoperative alignment, with TPA and T4PA changing notably for those who had lower thoracic fusions as opposed to upper thoracic fusions.
  • - The findings suggest that monitoring these specific angles during surgery could enhance the accuracy of adjustments made to correct spinal alignment, ultimately influencing recovery outcomes.
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Study Design: Single-center retrospective study.

Objective: To analyze two-year postoperative outcomes following spinopelvic fixation in pediatric patients using the anatomic trajectory (AT) portal for iliac screws.

Summary: Iliac fixation is crucial in situations requiring fusion to sacrum.

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Background: Current health-related quality of life (HRQL) metrics used to assess patient outcomes following surgical correction of cervical deformity (CD) are not deformity-specific and thus cannot capture all aspects of a patient's deformity and outcomes. The purpose of this study is to evaluate the sensitivity of different HRQL outcome measures in assessing CD patients' outcomes 1-year post-operatively.

Methods: Retrospective review of prospective multi-center database.

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Background: Patients undergoing multilevel spine surgery are at risk for delayed extubation.

Objective: To evaluate the impact of type and volume of intraoperative fluids administered during multilevel thoracic and/or lumbar spine surgery on postoperative extubation status.

Methods: Retrospective evaluation of medical records of patients ≥ 18 yr undergoing ≥ 4 levels of thoracic and/or lumbar spine fusions was performed.

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Background: Previous studies have built a foundation for understanding compensation in patients with adult spinal deformity (ASD) by using full-body stereographic assessments. These mechanisms, in relation to age-adjusted alignment targets, have yet to be studied fully. The aim of this study was to assess lower-limb compensatory mechanisms of patients failing to meet age-adjusted alignment goals.

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Study Design: Prospective multicenter cohort study with consecutive enrollment.

Objective: To evaluate preoperative alignment and surgical factors associated with suboptimal early postoperative radiographic outcomes after surgery for cervical deformity.

Summary Of Background Data: Recent studies have demonstrated correlation between cervical sagittal alignment and patient-reported outcomes.

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Purpose: Reciprocal mechanisms for standing alignment have been described in thoraco-lumbar deformity but have not been studied in patients with primary cervical deformity (CD). The purpose of this study is to report upper- and infra-cervical sagittal compensatory mechanisms in patients with CD and evaluate their changes post-operatively.

Methods: Global spinal alignment was studied in a prospective database of operative CD patients.

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Study Design: Retrospective analysis.

Purpose: Our hypothesis is that the surgical correction of adolescent idiopathic scoliosis (AIS) maintains normal sagittal alignment as compared to age-matched normative adolescent population.

Overview Of Literature: Sagittal spino-pelvic alignment in AIS has been reported, however, whether corrective spinal fusion surgery re-establishes normal alignment remains unverified.

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Background: Proximal junctional kyphosis (PJK) following adult spinal deformity (ASD) surgery is a well-documented complication, but associations between radiographic PJK and cervical malalignment onset remain unexplored.

Objective: To study cervical malalignment in ASD surgical patients that develop PJK.

Methods: Retrospective review of prospective multicenter database.

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Purpose: While there is a consensus that pelvic incidence (PI) remains constant after skeletal maturity, recent reports argue that PI increases after 60 years. This study aims to investigate whether PI increases with age and to determine potential associated factors.

Methods: 1510 patients with various spinal degenerative and deformity pathologies were enrolled, along with an additional 115 asymptomatic volunteers.

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Background: Primary drivers (PDs) of adult cervical deformity (ACD) have not been described in relation to pre- and early postoperative alignment or degree of correction.

Objective: To define the PDs of ACD to understand the impact of driver region on global postoperative compensatory mechanisms.

Methods: Primary cervical deformity driver/vertebral apex level were determined: CS = cervical; CTJ = cervicothoracic junction; TH = thoracic; SP = spinopelvic.

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