Hearing modulation affects Alzheimer's disease progression linked to brain inflammation: a study in mouse models.

Background: Recent studies have identified hearing loss (HL) as a primary risk factor for Alzheimer's disease (AD) onset. However, the mechanisms linking HL to AD are not fully understood. This study explored the effects of drug-induced hearing loss (DIHL) on the expression of proteins associated with AD progression in mouse models.

Anti-Obesity Activities of the Compounds from var. and Chemical Profiling of the Extract.

var. (Lamiaceae) is widely used not only as an oil or a spice, but also as a traditional medicine to treat colds, coughs, fever, and indigestion. As an ongoing effort, luteolin-7--diglucuronide (), apigenin-7--diglucuronide (), and rosmarinic acid () isolated from var.

Anti-Inflammatory Activity of the Constituents from the Leaves of var. .

var. (Lamiaceae) has been used to treat indigestion, asthma, and allergies in traditional medicine. In this study, luteolin 7--diglucuronide (), apigenin 7--diglucuronide (), and rosmarinic acid () were isolated from the leaves of var.

Borderline Malignant Sebaceoma of the Auricle: A Case Report.

Unlabelled: Sebaceoma is a rare benign tumor arising from the sebaceous gland of the skin. Sebaceoma often occurs on the head and neck but rarely on the ears. We present the case of a 78-year-old female patient with a two-year history of a protruding mass in her left ear.

The Use of Interdental Care Products in Korean Adults Aged 30 Years and Older and Factors Affecting Their Use: 4th to 7th Korean National Health and Nutrition Examination Survey.

This study aimed to review the use of interdental care products (ICPs) among adults in Korea, reconfirm their relevance to periodontal health, and identify factors affecting the use of ICPs. Data from 2007 to 2018 from the National Health Nutrition Survey (KNHANES) were used, and 43,069 adults (18,412 men, 24,657 women) aged 30 years or older were included. The frequency and percentage of ICP use according to the characteristics of the subjects are presented.

Consumer-grade sleep trackers are still not up to par compared to polysomnography.

Purpose: Although polysomnography (PSG) is the gold standard for monitoring sleep, it has many limitations. We aimed to prospectively determine the validity of wearable sleep-tracking devices and smartphone applications by comparing the data to that of PSGs.

Methods: Patients who underwent one night of attended PSG at a single institution from January, 2015 to July 2019 were recruited.

Association between Diabetes Mellitus and Oral Health Status in Patients with Cardiovascular Diseases: A Nationwide Population-Based Study.

Diabetes mellitus (DM) can lead to poor oral health. However, oral health among diabetic patients with cardiovascular diseases (CVDs) is scarcely studied. This study aimed to elucidate the prevalence of oral health complications and the relationship between DM and oral health status in diabetic patients with CVDs.

Nontraditional Risk Factors for Obesity in Modern Society.

Overweight and obesity, which have rapidly increased around the world in recent years, are significant health problems. They can lead to various morbidities, including cardiovascular diseases, cerebrovascular diseases, type 2 diabetes, some types of cancer, and even death. Obesity is caused by an energy imbalance due to excessive calorie intake and insufficient energy consumption, and genetic factors and individual behavioral problems are also known to be major contributing factors.

Relationship between Vitamin D Deficiency and Periodontitis in Korean Adults Aged ≥60 Years: Analysis of Data from the Korea National Health and Nutrition Examination Survey (2013-2014).

There have been contradictory reports on the effects of vitamin D in the prevention of periodontitis. We analyzed the association between vitamin D status (levels of plasma 25(OH)D) and periodontitis using the Korea National Health and Nutrition Examination Survey (KNHANES) 2013-2014 database. Among the participants in the KNHANES (2013-2014), only those aged ≥60 years who completed a health interview survey, periodontal examination, and blood test were included in the study.

Eudesmane and Eremophilane Sesquiterpenes from the Fruits of with Protective Effects against Oxidative Stress in Adipose-Derived Mesenchymal Stem Cells.

Miquel (Zingiberaceae) has been reported to show antioxidant, anti-inflammatory, and neuroprotective effects. In this study, two new eudesmane sesquiterpenes, 7α-hydroperoxy eudesma-3,11-diene-2-one () and 7β-hydroperoxy eudesma-3,11-diene-2-one (), and a new eremophilane sesquiterpene, 3α-hydroxynootkatone (), were isolated from the MeOH extract of dried fruits of along with eleven known sesquiterpenes (-). The structures were elucidated by the analysis of 1D/2D NMR, high-resolution electrospray ionization mass spectrometry (HRESIMS), and optical rotation data.

Antibacterial and antibiofilm activities of cinnamon essential oil nanoemulsion against multi-species oral biofilms.

Cinnamon essential oil (CEO) has antibacterial properties, but its ability to suppress the formation of multi-species oral biofilms has not been fully elucidated. This study evaluated the antibacterial and antibiofilm activities of cinnamon essential oil nanoemulsion (CEON) against oral biofilms formed using a microcosm biofilm model. The biofilms were formed on bovine enamel specimens over a 7-day period, during which all specimens were treated with one of three solutions: 5% CEON (n = 35), 0.

The Effect of Proximal Cleaning Devices on Periodontal Status in Korean Adults between 2016 and 2018.

Removal of the biofilm from the proximal space is essential for preventing periodontal disease. This study aimed to prove the association between the use of proximal cleaning devices, such as dental floss and interdental brushes, and periodontal health among nationally representative Korean adults. Data collected from the 7th National Health Nutrition Survey (KNHANES VII: 2016-2018) were used for this purpose.

Association between regular walking and periodontitis according to socioeconomic status: a cross-sectional study.

Physical activity reduces the risk and mortality risk of inflammatory diseases. This study aimed to examine the relationship between regular walking and periodontitis in a Korean representative sample of adults according to socioeconomic status. Data acquired by the Sixth Korea National Health and Nutrition Examination Survey in 2014 and 2015 were used.

The association between periodontitis and dyslipidemia according to smoking and harmful alcohol use in a representative sample of Korean adults.

Objectives: The aim of this study was to examine whether dyslipidemia is associated with periodontitis according to age, sex, smoking, and harmful alcohol use in a representative sample of Korean adults who participated in the Sixth Korea National Health and Nutrition Examination Survey (KNHANES VI-3).

Materials And Methods: We examined 3987 subjects aged 19 to 79 years who participated in the KNHANES VI-3. Dyslipidemia was defined according to the definition proposed by the Korean Society of Lipidology and Atherosclerosis.

The association between dyslipidemia, oral health behavior, and periodontal disease: The Korea National Health and Nutrition Examination Survey.

Objectives: This research aims to confirm the association between dyslipidemia, oral health behaviors, and periodontal disease according to age groups.

Method And Materials: This cross-sectional study used collected data from the Korea National Health and Nutrition Examination Survey (KNHANES) conducted from 2012 to 2015 with 17,004 adults. Complex samples logistic regression analysis confirmed the relevant factors of oral disease.

Trans-tympanic Cartilage Chip Insertion for Intractable Patulous Eustachian Tube.

Background And Objectives: Patulous Eustachian tube (PET) causes troublesome autophony. We treated PET using tragal cartilage chip insertion to fill in the concavity within the tubal valve and evaluated the feasibility of this method.

Subjects And Methods: This study used a prospective design.

Dispersion Polymerization of Polystyrene Particles Using Alcohol as Reaction Medium.

In this study, monodisperse polystyrene nanospheres were prepared by dispersion polymerization using alcohol as reaction medium to prepare colloidal clusters of the latex beads. Polyvinylpyrrolidone (PVP) and 2-(methacryloyloxy)ethyltrimethylammonium chloride (MTC) were used as dispersion stabilizer and comonomer, respectively. The particle size could be controlled by adjusting the reactant compositions such as the amount of stabilizer, comonomer, and water in the reactant mixture.

A Case of Sudden Deafness with Intralabyrinthine Hemorrhage Intralabyrinthine Hemorrhage and Sudden Deafness.

Sudden hearing deterioration may occur in our population, but it is difficult to explain the exact pathophysiology and the cause. Magnetic resonance imaging (MRI) in sudden sensorineural hearing loss (SSNHL) is usually useful to evaluate neural lesions such as acoustic schwannoma and hemorrhage in labyrinth. Recently some cases of SSNHL caused by intralabyrintine hemorrhage were reported by the advance of MRI.

Comparison of changes in etiologic microorganisms causing early-onset neonatal sepsis between preterm labor and preterm premature rupture of membranes.

Objective: To investigate changes in the etiologic microorganisms causing early-onset neonatal sepsis (EONS) in preterm labor (PTL) or preterm premature rupture of membranes (pPROM) cases over the past 16 years and to analyze the associated factors.

Methods: We included consecutive singleton pregnancies delivered before 34 weeks due to PTL or pPROM. The etiologic microorganisms causing EONS in PTL and pPROM cases were compared between period 1 (1996-2004) and period 2 (2005-2012).

G-quadruplex binding ligands: from naturally occurring to rationally designed molecules.

Guanine-rich nucleic acid sequences are known to form G-quadruplex - four-stranded DNA or RNA structures stabilized by an array of Hoogsteen hydrogen bonds. G-quadruplex structures are involved in the modulation of gene expression at the transcription and translation levels. Accordingly, G-quadruplexes are considered as novel therapeutic targets for anticancer drug development.

Otogenic pneumocephalus associated with a ventriculoperitoneal shunt.

Otogenic pneumocephalus is a condition of intracranial air originating from the middle ear or mastoid air cells. This communication between the intracranial cavity and the pneumatic cavities is usually associated with trauma after cranial fractures or iatrogenic trauma. We present a rare case of otogenic pneumocephalus arising in the left posterior fossa from wellpneumatized mastoid air cells.

Cyano-bridged hexanuclear Fe4M2 (M = Ni, Co, Mn) clusters: spin-canted antiferromagnetic ordering of Fe4Ni2 cluster.

Heterobimetallic hexanuclear cyano-bridged complexes, [{Fe(Tp)(CN)3}4{M(MeCN)(H2O)2}(2)].10H2O.2MeCN [M = Ni (1), Co (2), Mn (3); Tp = hydrotris(1-pyrazolyl)borate], have been synthesized in H2O-MeCN solution.

trans-Bis(isothiocyanato-kappaN)bis(methanol-kappaO)bis[2,4,6-tri(4-pyridyl)-1,3,5-triazine-kappaN(2)]manganese(II).

The title compound, [Mn(NCS)(2)(C(18)H(12)N(6))(2)(CH(4)O)(2)], contains a centrosymmetric octahedral Mn(II) centre and three pairs of trans-coordinating ligands. It is the first example of a mononuclear metal complex with the 2,4,6-tri(4-pyridyl)-1,3,5-triazine (tpt) ligand. Intermolecular pi-pi stacking of the planar tpt ligands, as well as hydrogen bonds between pyridyl N and methanol H atoms, results in the formation of a three-dimensional network.