Effect of Home Enteral Nutritional Support Compared With Normal Oral Diet in Postoperative Subjects With Upper Gastrointestinal Cancer Resection: A Meta-Analysis.

Introduction: We performed a meta-analysis to evaluate the influence of a home enteral nutritional support compared with a normal oral diet in postoperative subjects with upper gastrointestinal cancer resection.

Methods: A systematic literature search up to December 2021 was done and 23 studies included 3,010 subjects with upper gastrointestinal cancer resection at the start of the study; 1,556 of them were given home enteral nutritional support and 1,454 were normal oral diet. We calculated the odds ratio (OR) and mean difference (MD) with 95% CIs to evaluate the influence of home enteral nutritional support compared with a normal oral diet in postoperative subjects with upper gastrointestinal cancer resection by the dichotomous or continuous methods with a random or fixed-influence model.

Preparation of Anti-Aristolochic Acid I Monoclonal Antibody and Development of Chemiluminescent Immunoassay and Carbon Dot-Based Fluoroimmunoassay for Sensitive Detection of Aristolochic Acid I.

Aristolochic acid (AA) toxicity has been shown in humans regarding carcinogenesis, nephrotoxicity, and mutagenicity. Monitoring the AA content in drug homologous and healthy foods is necessary for the health of humans. In this study, a monoclonal antibody (mAb) with high sensitivity for aristolochic acid I (AA-I) was prepared.

Intestinal Models for Personalized Medicine: from Conventional Models to Microfluidic Primary Intestine-on-a-chip.

Intestinal dysfunction is frequently driven by abnormalities of specific genes, microbiota, or microenvironmental factors, which usually differ across individuals, as do intestinal physiology and pathology. Therefore, it's necessary to develop personalized therapeutic strategies, which are currently limited by the lack of a simulated intestine model. The mature human intestinal mucosa is covered by a single layer of columnar epithelial cells that are derived from intestinal stem cells (ISCs).

Synthesis and biological evaluation of novel oleanolic acid analogues as potential α-glucosidase inhibitors.

Considerable interest has been attracted in oleanolic acid and its analogues because of their hypoglycemic activity. In this study, a series of novel oleanolic acid analogues against α-glucosidase were synthesized and their biological activities were evaluated in vitro and in vivo. In vitro α-glucosidase inhibition activity results indicated that most of the designed analogues exhibited prominent inhibition activities, especially compounds 10, 15, 16 and 26 which with the IC values of 0.

The biological evaluation of fusidic acid and its hydrogenation derivative as antimicrobial and anti-inflammatory agents.

Background: Fusidic acid (FA) (WU-FA-00) is the only commercially available antimicrobial from the fusidane family that has a narrow spectrum of activity against Gram-positive bacteria.

Methods: Herein, the hydrogenation derivative (WU-FA-01) of FA was prepared and both compounds were examined against a panel of six bacterial strains. In addition, their anti-inflammatory properties were evaluated using a 12--tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema model.

Synthesis and biological evaluation of novel ursolic acid analogues as potential α-glucosidase inhibitors.

Ursolic acid (UA) is a major pentacyclic triterpenoid in plants, vegetables and fruits, which has been reported to have a potential anti-diabetic activity. Despite various semi-synthetic ursolic acid derivatives already described, new derivatives still need to be designed and synthesized to further improve the anti-diabetic activity. In the present study, two series of novel UA derivatives, were synthesized and their structures were confirmed.

Anti-inflammatory activity effect of 2-substituted-1,4,5,6-tetrahydrocyclopenta[b]pyrrole on TPA-induced skin inflammation in mice.

2-Substituted-1,4,5,6-tetrahydrocyclopenta[b]pyrrole, a key structural moiety exiting in many bioactive molecules, has been shown to have excellent selective activity on COX-2. In the present study, the anti-inflammatory activity and the underlying molecular mechanism of 2-substituted-1,4,5,6-tetrahydrocyclopenta[b]pyrrole on skin inflammation were assessed by 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation in mice. Most of the compounds showed anti-inflammatory activity on TPA-induced skin inflammation.

Pyridine analogues of curcumin exhibit high activity for inhibiting CWR-22Rv1 human prostate cancer cell growth and androgen receptor activation.

The concentrations required for curcumin to exert its anticancer activity (IC, 20 µM) are difficult to achieve in the blood plasma of patients, due to the low bioavailability of the compound. Therefore, much effort has been devoted to the development of curcumin analogues that exhibit stronger anticancer activity and a lower IC than curcumin. The present study investigated twelve pyridine analogues of curcumin, labeled as groups AN, BN, EN and FN, to determine their effects in CWR-22Rv1 human prostate cancer cells.

Chemical composition, antimicrobial property and microencapsulation of Mustard (Sinapis alba) seed essential oil by complex coacervation.

In this study, the essential oil from mustard seed was isolated by simultaneous steam distillation and extraction (SDE) and analyzed by gas chromatography-mass spectrometry (GC-MS). Fourteen components were identified in the mustard seed essential oil with allyl isothiocyanate being the main component (71.06%).

In vitro and in vivo evaluation of the antidiabetic activity of ursolic acid derivatives.

In this study, a series of ursolic acid derivatives were synthesized, and their structures were confirmed. The activity of the synthesized compounds against α-glucosidase was determined in vitro. The results suggested that all compounds have significant inhibitory activity, especially compounds 3-5 and 8, the IC50 values of which were 2.

Cd-doped ZnO quantum dots-based immunoassay for the quantitative determination of bisphenol A.

Bisphenol A (BPA) is a ubiquitous environmental contaminant in food products and aquatic ecosystems. Its endocrine and developmental toxicity presents a serious concern to human health and an effective high-throughput method for its detection is desirable. In this paper, water-soluble quantum dots (QDs) have been conjugated covalently with BPA antibodies and the conjugate has been utilized in a competitive fluorescence-linked immunoassay (FLISA).

[Enzymatic extraction and antibacterial activity of aucubin from Eucommia ulmoides leaves].

Objective: To investigate the technology of Aucubin in Eucommia ulmoides leaves extracted by enzymatic method and its antibacterial activity.

Methods: Aucubin in Eucommia ulmoides leaves was extracted by cellulase method. The extraction technology was optimized using the content of Aucubin as index.

A study of photoluminescence properties and performance improvement of Cd-doped ZnO quantum dots prepared by the sol-gel method.

In the present work, ZnO quantum dots (QDs) have been prepared by the sol-gel method, and the performance of the QDs has been improved. The effect of Cd concentration on the structural and luminescent properties of the QDs, as well as the effect of the mass ratio of trioctylphosphine oxide (TOPO)/octadecylamine (ODA), has been investigated. The ZnO and Cd-doped ZnO QDs have hexagonal wurtzite structures and are 3 to 6 nm in diameter.

[Study on the extraction technology of total flavonoids from Selaginella uncinata].

Objective: To optimize the extraction technology of total flavonoids and improve the extraction ratio of total flavonoids from Selaginella uncinata.

Methods: Using the content of flavonoids as the index determined by UV spectrophotometry, chose single factor experiment to investigate the total flavonoids content influenced by four factor ethanol concentration, extracting time, extraction times and solvent content on the influence of extraction efficiency. And on the basis, L9 (3(4)) orthogonal experiment was carried out.

[Preparation and characterization of quantum dots with polyacrylic acid modified method in water-soluble core-shell structure].

Cd-Zn quantum dots (QDs) modified with thiourea was firstly prepared asthe cores, then the cores were coated with polyacrylic acid with PVP K-30 as the stabilizer in water-soluble reaction system. The water-soluble fluorescence QDs were the same size and stable. The water-soluble QDs were characterized by fluorescence emission spectra, infrared spectra (IR), and transmission electron microscopy (TEM).

[Studies on the lowering blood sugar substances from agrimony (II)].

Objective: To isolate and identify the chemical constituents from the active section with lowering blood sugar of agrimony.

Methods: The compounds were separated by repeated silica gel, polyamide and HPLC chromatographies. The structures of compounds isolated were identified by analysis of their spectral data and chemical peoperties.

[The determination of three effective constituents in wild and cultivated Gastrodia elata from Bomi].

Objective: To determine the contents of gastrodin, amino acids and total flavonoids in wild and cultivated Gastrodia elata, in order to choose the best method for its cultivation. The Gastrodia elata was picked at Guxiang town Bomi county Linzhi Region in Tibet.

Methods: HPLC was used to determine the content of gastrodin.

Preparation of artificial antigen and egg yolk-derived immunoglobulin (IgY) of citrinin for enzyme-linked immunosorbent assay.

Objective: To prepare artificial antigens and anti-citrinin egg yolk-derived immunoglobulin (IgY) to build an enzyme-linked immunosorbent assay (ELISA) for citrinin (CTN).

Methods: CTN was conjugated with bovine serum albumin (BSA), ovalbumin (OVA) with formaldehyde condensation method to prepare artificial antigens and identified by ultraviolet (UV) spectrometry and Infrared (IR) spectrometry. Artificial antigens for CTN and anti-CTN IgY were purified with polyethylene glycol two-step precipitation method and identified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE).

[Inhibition of extracts from Synotis erythropappa on tyrosinase].

Objective: To study the inhibition of extracts from Synotis erythropappa on tyrosinase.

Methods: The 70% ethanol extracts were extracted by petroleum benzine, ethyl acetate and n-butanol, and the inhibitory activities against tyrosinase of every fraction were determined in vitro and the inhibitory kinetics of ethyl acetate and n-butanol fractions were investigated.

Results: The four fractions extracted all had inhibitory activities on tyrosinase, inhibitory activities of ethyl acetate and n-butanol fraction were higher.

2-Amino-6-nitro-1H-benzoimidazol-3-ium chloride.

In the cation of the title compound, C(7)H(7)N(4)O(2) (+)·Cl(-), the benzimidazole ring system is planar with a maximum deviation of -0.019 (3) Å. In the crystal structure, C-H⋯Cl, N-H⋯Cl, and N-H⋯Cl inter-actions link the mol-ecules into a two-dimensional network.

[Study on spectral and immune identification of artificial antigen of bisphenol A].

Bisphenol A(BPA) is able to mimic the effects of endogenous hormones and it influences the central nervous system in human being. In recent years, BPA has largely arisen because it is released into our environment from many kinds of the polycarbonate plastics and epoxy resins of food cans. Because trace residual amount of BPA might be harmful to human being, many instrument analysis methods have been developed for the determination of BPA.