Publications by authors named "Su-juan Hu"
The aim of the present study was to provide evidence for the application of probiotics in the prevention and treatment of infantile eczema by exploring changes in the intestinal levels and the Scoring Atopic Dermatitis (SCORAD) index prior and subsequent to treatment with probiotics in infants with eczema. A total of 40 infants with eczema were randomly divided into treatment and control groups. Prior and subsequent to the treatment, the SCORAD index was evaluated and the content of in the stool of each infant in the two groups was quantified using 16S rRNA/DNA quantitative polymerase chain reaction analysis.
View Article and Find Full Text PDFOur previous genome-wide association studies on SLE have identified several susceptibility genes involved in NF-κB signaling pathway, including TNFSF4, TNFAIP3, TNIP1, BLK, SLC15A4 and UBE2L3. The aim of this study is to investigate the association model (additive, dominant, recessive) of these genes and search for possible gene-gene interactions between them. In this study, we explored the association model of these six genes and search for possible gene-gene interactions based on identified single-nucleotide polymorphisms (SNPs) among them by using logistic regression analysis in the combined sample of 4,199 cases and 8,255 controls.
View Article and Find Full Text PDFArticle Synopsis
- IKZF1 is a zinc finger transcription factor that regulates lymphocyte differentiation and acts as a tumor suppressor in hematological diseases.
- Genome-wide association studies have identified genetic variants in IKZF1 linked to systemic lupus erythematosus (SLE), suggesting its involvement in the disease.
- Lower expression of IKZF1 may activate pathways connected to SLE, and its role in various blood disorders points to its significance in the pathogenesis of SLE, highlighting potential therapeutic strategies.
[Effect of okam on inflammation and remodeling of airway of mice with ovalbumin induced asthma].
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
April 2009
Objective: To investigate the effect of okam on inflammation and remodeling of airway in mice with ovalbumin (OVA) induced asthma.
Methods: Thirty-two mice of Kunming strain were divided into four groups randomly: model group, glucocorticoid inhalation group, okam group and control group, with 8 mice in each group. The asthmatic mice model was reproduced by combined injection and aerosol inhalation of OVA.