Publications by authors named "Su-hua Wu"
Article Synopsis
- * An observational study of 15,792 individuals found that low serum potassium and magnesium levels were associated with a higher risk of AF, while increased phosphate levels were also linked to greater incidence, but calcium levels showed no correlation.
- * Despite these associations, the study concluded that serum electrolytes are not causal factors for AF development, suggesting they could be used as prognostic indicators rather than direct causes.
Early repolarization syndrome (ERS) is defined as occurring in patients with early repolarization pattern who have survived idiopathic ventricular fibrillation with clinical evaluation unrevealing for other explanations. The pathophysiologic basis of the ERS is currently uncertain. The objective of the present study was to examine the electrophysiological mechanism of ERS utilizing induced pluripotent stem cells (iPSCs) and CRISPR/Cas9 genome editing.
View Article and Find Full Text PDFAdministration of macrolide antibiotics increases cardiovascular risk.
Front Cardiovasc Med
February 2023
Background: The increased risk of cardiovascular events in patients prescribed macrolides has been subject to debate for decades.
Methods: Medline, EMBASE databases and ClinicalTrials.gov were searched from inception until August 31, 2022 for studies investigating the link between macrolides and cardiovascular risk.
Objective: To examine the association of systolic blood pressure (SBP) and cardiovascular risk in normotensive adults.
Patients And Methods: This study analyzed data from 7 prospective cohorts between September 29, 1948, and December 31, 2018. Complete information on history of hypertension and baseline blood pressure measurements were required for inclusion.
The electro-cautery lumen apposing metal stent (EC-LAMS) is a newly developed device that integrates the electro-cautery cyctotome with the one-step metal stent delivery and releasing system in recent years. LAMS was first designed to complete the drainage of pancreatic fluid collection under endoscopic ultrasound guidance, and the technological innovation of EC-LAMS has made more off-labeled indications of endoscopic intervention for gastrointestinal diseases realized, such as abdominal fluid drainage, bile duct, or gallbladder drainage through stomach or duodenum, gastrointestinal anastomosis, and the establishment of fistulous channel for further endoscopic operation when necessary. The unique feature of this metal stent is that it has the design of a saddle shape and a large lumen, and can almost connect the adjacent structures to minimize the risk of perforation and leakage.
View Article and Find Full Text PDFDespite improvements in cardiovascular disease (CVD) outcomes by cholesterol-lowering statin therapy, the high rate of CVD is still a great concern worldwide. Dehydrocorydaline (DHC) is an alkaloidal compound isolated from the traditional Chinese herb Corydalis yanhusuo. Emerging evidence shows that DHC has anti-inflammatory and antithrombotic benefits, but whether DHC exerts any antiatherosclerotic effects remains unclear.
View Article and Find Full Text PDFBackground: Growing evidence suggests that compromised lung health may be linked to cardiovascular disease. However, little is known about its association with sudden cardiac death (SCD).
Objectives: We aimed to assess the link between impaired lung function, airflow obstruction and risk of SCD by race and gender in four US communities.
Article Synopsis
- The study investigates the long-term effects of individual changes in body mass index (BMI) on cardiovascular outcomes, using data from four large cohorts with participants aged 45 and older who had multiple BMI measurements.
- Over a median follow-up of 21 years with 29,311 individuals, the research found a U-shaped relationship between BMI trajectories and major adverse cardiovascular events (MACE), indicating higher risks associated with both rapid weight loss and gain compared to maintaining stable weight.
- The results suggest that monitoring BMI changes can identify high-risk individuals for cardiovascular issues, highlighting the need for further research in weight management strategies.
Background Although silent myocardial infarction (SMI) is prognostically important, the risk of sudden cardiac death (SCD) among patients with incident SMI is not well established. Methods and Results We examined 2 community-based cohorts: the ARIC (Atherosclerosis Risk in Communities) study (n=13 725) and the CHS (Cardiovascular Health Study) (n=5207). Incident SMI was defined as electrocardiographic evidence of new myocardial infarction during follow-up visits that was not present at the baseline.
View Article and Find Full Text PDFArticle Synopsis
- Catheter ablation (CA) is an effective first-line treatment for atrial fibrillation (AF), and a meta-analysis was conducted to compare its long-term outcomes and quality of life (QoL) with antiarrhythmic drugs (AADs).
- The analysis included 20 randomized controlled trials with over 5,400 participants, revealing that CA significantly reduced the risk of all-cause death and cardiovascular hospitalization compared to AADs, though it increased the risk of cardiac tamponade.
- Both CA and AADs improved QoL, with CA showing better outcomes on the Medical Outcomes Study SF-36 for both physical and mental health components, along with significant improvements from baseline to follow-up.
Autonomic Influences Related to Early Repolarization in Patients Without Structural Heart Disease.
J Cardiovasc Transl Res
December 2020
Article Synopsis
- * Researchers measured various time-domain indexes (like SDNN and RMSSD) and found significant differences across the three groups, with ERP type 2 showing the highest values.
- * The analysis indicated that nighttime SDNN and gender were significantly linked to J-point elevation, suggesting a relationship between HRV and different ERP types based on ECG characteristics.
Background: Early repolarization pattern (ERP) was associated with sudden cardiac death in recent studies. However, the associations between ERP and coronary artery disease (CAD), and ERP and cardiac death caused by acute myocardial infarction (MI) remains unclear.
Methods: We retrospectively enrolled consecutive 1,545 CAD patients and 908 non-CAD subjects as control group which were confirmed by coronary angiograph.
Article Synopsis
- Early repolarization syndrome (ERS) is linked to genetic mutations, with the study focusing on the unclear role of the GPD1-L mutation P112L in its development.
- Whole-genome sequencing and various laboratory techniques demonstrated that the P112L mutation resulted in lower protein expression of GPD1-L and a significant reduction in sodium current activation (INa) in transfected cells.
- The findings indicate that the GPD1-L P112L mutation may contribute to the pathogenesis of ERS by impairing GPD1-L function and altering its cellular distribution.
Backgound: Silent electrocardiographic ST change predicts future coronary heart disease (CHD) incidence and mortality, but the prognostic significance of painless ST-segment depression (STD) with respect to sudden cardiac death (SCD) in subjects without apparent CHD remain unclear. This study sought to test the association between non-ischemic resting STD and risk of SCD in the general population.
Methods: A total of 14,935 middle-aged subjects from the prospective, population-based Atherosclerosis Risk in Communities (ARIC) study were included in this analysis.
Article Synopsis
- - The study investigates the role of the DPP6-L747P variant in early repolarization syndrome (ERS) linked to sudden cardiac arrest, building on previous findings about DPP6's involvement in idiopathic ventricular fibrillation.
- - Researchers identified the DPP6-L747P genetic variant through whole genome sequencing in four Chinese families and conducted functional experiments to understand its effects on potassium currents in HEK293 cells.
- - Results showed that the DPP6-L747P variant leads to increased macroscopic currents and alters activation and inactivation properties of DPP6, suggesting it enhances potassium current activity, potentially contributing to ERS-related cardiac events.
Background: Interleukin-1 (IL-1) played a role in the occurrence and development of atherosclerosis and cardiovascular events. However, the association between IL-1 blockage treatment and reducing of cardiovascular risk remains poorly defined.
Hypothesis: IL-1 blockage treatment reduce the risk and incidence rate of overall major adverse cardiovascular events (MACE), all-cause death, acute myocardial infarction(MI), unstable angina and heart failure.
A Heterozygous Missense hERG Mutation Associated with Early Repolarization Syndrome.
Cell Physiol Biochem
January 2019
Background/aims: Early repolarization syndrome (ERS) has been recently recognized as early repolarization pattern with idiopathic ventricular fibrillation. However, the genetic background of ERS has not been fully understood.
Methods: A Chinese family with sudden cardiac death associated with ERS was investigated.
Article Synopsis
- Abnormalities in heart ion channels can lead to a condition called early repolarization syndrome (ERS), which affects how the heart resets after each beat.
- Researchers studied genes from families with ERS to see how certain mutations in the SCN1Bβ gene impacted heart function.
- They found that specific mutations increased a type of potassium current, which might help explain why people in these families have ERS.
Article Synopsis
- Recent research indicates that mutations in the KCNE1 gene, which encodes a β-subunit of cardiac potassium channels, are linked to ventricular fibrillation and might also play a role in early repolarization syndrome (ERS), although this connection is not fully understood.
- The study aimed to investigate the association of the KCNE1 mutation, specifically S38G, with ERS by analyzing genomic data from four families and performing various functional tests in a laboratory setting.
- Findings revealed that the S38G mutation resulted in reduced protein expression and impaired membrane trafficking of KCNE1, leading to decreased electrical currents, suggesting that KCNE1 could be a significant gene involved in the modulation of early repolarization syndrome.
Background: A slower heart rate can exaggerate J-point elevation in a 12-lead ECG. This study examined the role of Holter monitoring in the diagnosis of early repolarisation pattern (ERP).
Methods: We examined 24-hour Holter recordings of 4000 consecutive patients seen at an outpatient clinic, and found 500 patients (12.
Background: Radiotherapy for breast cancer often involves some incidental exposure of the heart to ionizing radiation. The effect of this exposure on the subsequent risk of heart disease is uncertain. We performed a meta-analysis to investigate the link between radiotherapy and long-term cardiovascular morbidity and mortality in patients with breast cancer.
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- Early repolarization pattern (ERP) is linked to a higher risk of dangerous heart rhythms and sudden cardiac death, especially in individuals with structural heart disease (SHD).
- A meta-analysis of 19 studies involving over 7,000 patients demonstrated that those with ERP faced significantly increased odds of experiencing ventricular arrhythmias and sudden cardiac death compared to those without ERP.
- The findings indicate a need for more research to understand the mechanisms behind this increased risk and to include ERP in risk assessments for patients with SHD.
Article Synopsis
- Recent evidence suggests that early repolarization pattern (ERP) on ECGs is linked to sudden cardiac death (SCD) in patients without structural heart issues, but its significance in those with atherosclerotic risk has been unclear.
- A study involving 18,231 participants with atherosclerotic risk factors followed them for an average of 7.6 years, finding that those with ERP had significantly higher risks for SCD, coronary heart disease (CHD) death, and overall mortality.
- The findings indicate that ERP is a concerning marker in at-risk populations, particularly due to its strong association with increased SCD and CHD mortality.
Article Synopsis
- - The study investigates the relationship between early repolarization pattern (ERP) and the risk of sudden cardiac arrest (SCA), cardiac death, and overall mortality, finding a significant increase in these risks for individuals with ERP, especially among Asians and whites.
- - A comprehensive meta-analysis included 16 studies and over 334,500 subjects, revealing individuals with ERP had a relative risk of 2.18 for SCA, 1.48 for cardiac death, and 1.21 for death from any cause compared to those without ERP.
- - The research highlights the need for further studies to understand the mechanisms behind ERP's arrhythmogenic potential and to develop effective risk assessment tools for patients.
Objectives: To study the role of the Rho/ROCK pathway in Ang II and TGF-β1-induced atrial remodeling.
Methods And Results: A canine atrial fibrillation (AF) model was established by rapid atrial pacing (RAP) of the left atrium. The roles of TGF-β1, the RhoA/ROCK signaling pathway and connective tissue growth factor (CTGF) in atrial remodeling were studied via both in vitro and in vivo experiments.