Publications by authors named "Su-hong Mu"
Elevated Soluble Podoplanin Associates with Hypercoagulability in Patients with Nephrotic Syndrome.
Clin Appl Thromb Hemost
July 2022
Article Synopsis
- Podoplanin (PDPN) interacts with the CLEC-2 receptor on platelets, promoting platelet aggregation and increasing the risk of venous thrombosis, especially in inflammatory conditions.
- A study involving 35 nephrotic syndrome patients and 27 healthy volunteers found that PDPN levels were significantly higher in patients, correlating with various markers of hypercoagulability.
- PDPN demonstrated good predictive value for hypercoagulability in nephrotic syndrome with an area under the curve (AUC) of 0.886, indicating that higher PDPN levels (>5.88 ng/ml) significantly increase the risk of thrombosis.
Chronic kidney disease (CKD) and peripheral arterial disease (PAD) share common risk factors. We assessed renal function and the prevalence of CKD in patients with PAD and investigated the characteristics of the risk factors for CKD in this population. Renal function of 421 patients with PAD was evaluated.
View Article and Find Full Text PDF[Atorvastatin attenuates parathyroid hormone 1-34 induced cardiomyocytes hypertrophy through downregulating K-Ras-ERK1/2 pathway].
Zhonghua Xin Xue Guan Bing Za Zhi
December 2012
Objective: To investigate the effects of atorvastatin on parathyroid hormone 1-34 (PTH1-34) induced neonatal rat cardiomyocytes hypertrophy and on the expression changes of small GTP-binding protein (K-Ras) and extracellular signal regulated protein kinases 1/2 (ERK1/2).
Methods: Neonatal rat cardiomyocytes hypertrophy was established with 10(-7) mol/L rPTH1-34 in the presence or absence of 10(-5) mol/L atorvastatin or 10(-4) mol/L mevalonic acid (MVA). Cardiomyocyte diameter was measured by Motic Images Advanced 3.
Article Synopsis
- Chronic renal disease (CKD) is a significant global health issue, especially prevalent in patients with coronary artery disease (CAD).
- A study involving 527 CAD patients assessed renal function, focusing on risk factors for CKD without considering proteinuria.
- Key findings indicated that age, smoking, diabetes, hypertension, and high systolic blood pressure are major CKD risk factors, with hypertension and diabetes being particularly common in patients with more severe kidney impairment.
Article Synopsis
- - The study investigates serum levels of interleukin-33 (IL-33) and soluble ST2 (sST2) in chronic kidney disease (CKD) patients to understand their relation to disease severity.
- - Among 69 CKD patients and 12 healthy controls, results showed no significant difference in IL-33 levels, but sST2 levels were higher in CKD patients and correlated significantly with disease severity.
- - The findings suggest that elevated sST2 levels in CKD patients could indicate more severe disease and might be linked to other factors like parathyroid hormone, highlighting sST2's potential role in disease progression.
[Expression and significance of CD80/CD86 in renal tissue of lupus nephritis].
Zhonghua Nei Ke Za Zhi
August 2010
Objective: To measure the expression of CD80 and CD86 in renal tissue of lupus nephritis (LN) and explore its mechanism in the development of LN.
Methods: Forty-nine patients with active LN and 9 patients with minor glomerular abnormalities tissues as controls were studied. The expression of CD80 and CD86 in renal tissues was detected by immunohistochemical methods.