Publications by authors named "Su-Yu Li"

The combination of anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (mAb) and doublet chemotherapy is the standard first-line treatment for patients with wild-type metastatic colorectal cancer (mCRC). Some patients may require secondary resection after first-line treatment. However, it remains unclear whether targeted therapy should be continued after liver resection.

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This multicenter study explored the survival benefits of upfront primary tumor resection (PTR) followed by first-line cetuximab plus chemotherapy in real-world patients with wild-type metastatic colorectal cancer (mCRC). Treatment options for mCRC include chemotherapy, targeted therapy, immunotherapy, and surgery. The efficacy of upfront PTR in managing mCRC remains unclear.

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Article Synopsis
  • - Patients with advanced/metastatic urothelial carcinoma who previously responded to or maintained stable disease with pembrolizumab immunotherapy may benefit from retreatment after disease progression, based on a post hoc analysis involving 49 patients from earlier clinical trials.
  • - The study found that 41% of these patients achieved an objective response following retreatment, with a notable percentage having had a complete response during the initial treatment, and the median duration of the response was around 14 months.
  • - Additionally, the retreatment led to manageable adverse effects, with only 45% experiencing treatment-related events, indicating that pembrolizumab retreatment is a viable and relatively safe option for select patients.
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Background: Robot-assisted surgery has been increasingly adopted in colorectal cancer resection.

Objective: The study aimed to compare the inpatient outcomes of robot-assisted versus conventional laparoscopic colorectal cancer resection in patients aged 75 years and older.

Design: A retrospective, population-based study.

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Background: Studies on the correlation between high body mass index (BMI) and extended survival among patients receiving immune checkpoint inhibitors (ICIs) have been made, although findings have shown variability. Our research explored the phenomenon of the "obesity paradox" in patients with metastatic urothelial carcinoma (mUC) undergoing treatment with ICIs.

Materials And Methods: We conducted a retrospective analysis of patients diagnosed with mUC who received a minimum of one cycle of ICI treatment at two medical centers in Taiwan from September 2015 to January 2023.

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Article Synopsis
  • A multicenter study assessed the survival benefits of combining metastasectomy with first-line cetuximab-based chemotherapy in patients with wild-type metastatic colorectal cancer (mCRC), measuring overall survival (OS) and progression-free survival (PFS) as primary endpoints.
  • Of the 758 enrolled patients, the study found that those who underwent metastasectomy had significantly better OS (54.9 months) and PFS (21.0 months) compared to those who did not, highlighting the importance of this surgical intervention in treatment outcomes.
  • The analysis also identified that patients receiving 14 or more treatment cycles had improved survival rates and higher chances of undergoing metastasectomy, suggesting this as an optimal treatment duration for maximizing outcomes in m
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Purpose: Numerous studies have produced conflicting findings regarding the efficacy of statins in prostate cancer treatment. Our objective was to examine the correlation between statin usage and clinical outcomes in Taiwanese men with metastatic prostate cancer.

Materials And Methods: We identified patients diagnosed with metastatic prostate cancer from the Chang Gung Research Database spanning the years 2007 to 2020.

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Bladder cancer is a common cancer with well-established therapeutic strategies. However, recurrence occurs in 50% of patients with non-muscle-invasive bladder cancer, and 20% of patients progress to muscle-invasive bladder cancer. The 5-year survival rate for muscle-invasive bladder cancer patients is disappointingly low, ranging from 36% to 48%.

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Background: Pembrolizumab plus lenvatinib has shown antitumor activity and acceptable safety in patients with platinum-refractory urothelial carcinoma (UC).

Objective: To evaluate pembrolizumab plus either lenvatinib or placebo as first-line therapy for advanced UC in the phase 3 LEAP-011 study.

Design, Setting, And Participants: Patients with advanced UC who were ineligible for cisplatin-based therapy or any platinum-based chemotherapy were enrolled.

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Article Synopsis
  • Patients with variant-type urothelial carcinoma (vUC) have limited effective treatment options compared to those with pure urothelial carcinoma (pUC), and the effectiveness of immune checkpoint inhibitors (ICI) in vUC is still uncertain.
  • A study involving 142 patients found that the overall response rate (ORR) to ICI was higher in pUC (34.5%) compared to vUC (23.1%), with no complete responses seen in vUC cases.
  • Despite similarities in progression-free survival (PFS) and overall survival (OS) between both groups, patients with pUC who received ICI as first-line treatment had significantly better OS compared to vUC patients, indicating ICI may be a viable
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Lymph node metastasis has been shown to positively associated with the prognosis of many cancers. However, in clinical treatment, lymphadenectomy is not always successful, suggesting that immune cells in the tumor and sentinel lymph nodes still play a pivotal role in tumor immunosuppression. Recent studies had shown that tumors can tolerate immune cells through multiple strategies, including tumor-induced macrophage reprogramming, T cells inactivation, production of B cells pathogenic antibodies and activation of regulatory T cells to promote tumor colonization, growth, and metastasis in lymph nodes.

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  • Malnutrition is a frequent issue in patients with metastatic colorectal cancer (mCRC) undergoing targeted therapy and chemotherapy, leading to increased toxicity and lower survival rates.
  • This study analyzed data from 758 patients treated with cetuximab and chemotherapy, separating them into groups that did or did not receive supplemental home parenteral nutrition (HPN).
  • Results showed that the HPN group had higher rates of successful surgeries, longer treatment durations, and improved overall and progression-free survival compared to the non-HPN group, suggesting HPN may enhance treatment outcomes for certain mCRC patients.
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Urothelial carcinoma (UC) is characterized by a high incidence of mutation, and overcoming resistance to cisplatin-based chemotherapy in UC is a major concern. Wee1 is a G2/M phase regulator that controls the DNA damage response to chemotherapy in -mutant cancers. The combination of Wee1 blockade with cisplatin has shown synergistic efficacy in several types of cancers, but little is known regarding UC.

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Purpose: The purpose of this study was to investigate the effect of integrated evaluation of resting static computed tomography perfusion (CTP) and coronary computed tomography angiography (CCTA)-derived fractional flow reserve (FFR CT ) on therapeutic decision-making and predicting major adverse cardiovascular events (MACEs) in patients with suspected coronary artery disease.

Materials And Methods: In this post hoc analysis of a prospective trial of CCTA in patients assigned to either CCTA or CCTA plus FFR CT arms, 500 patients in the CCTA plus FFR CT arm were analyzed. Both resting static CTP and FFR CT were evaluated by using the conventional CCTA.

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Versican (VCAN), also known as extracellular matrix proteoglycan 2, has been suggested as a potential biomarker in cancers. Previous research has found that VCAN is highly expressed in bladder cancer. However, its role in predicting outcomes for patients with upper urinary tract urothelial cancer (UTUC) is not well understood.

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Sarcopenia has been associated with conventional chemotherapy-related toxicity, postoperative complications and poor overall survival in patients with genotype-unselected metastatic colorectal cancer (mCRC). This study aimed to evaluate the prognostic implications of sarcopenia and its change after perioperative cetuximab plus doublet chemotherapy and hepatectomy in patients with RAS wild-type colorectal liver metastasis (CRLM). Patients with CRLM from 2007 to 2018 in Chang Gung Research Database were retrospectively analyzed.

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Lymphovascular invasion (LVI) predicts poor survival in patients with pathologically localized or locally advanced upper urinary tract urothelial carcinoma (UT-UC). However, LVI is associated with high tumor grade, tumor necrosis, advanced tumor stage, tumor location, concomitant carcinoma in situ, lymph node metastasis, and sessile tumor architecture. These factors might interfere with the analysis of the impact of LVI on oncological prognosis.

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While radium (Ra)-223 is among the multiple, known life-prolonging treatments in bone-predominant metastatic castration-resistant prostate cancer (mCRPC), optimal treatment sequencing has not been determined, particularly in the Asia-Pacific context. Hence, we aimed to compare treatment outcomes of docetaxel-naïve and post-docetaxel mCRPC patients undergoing Ra-223 therapy in Taiwan. Using a single-center retrospective cohort design, we reviewed records of adult patients receiving Ra-223 for bone-metastatic mCRPC from 2018 to 2021.

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Objective: The purpose of this study was to assess the effects of moving cupping therapy in people with colorectal cancer (CRC) experiencing chemotherapy-related side effects.

Methods: A prospective observational study was conducted in people diagnosed with CRC who were treated for the side effects of their chemotherapy. Participants received cupping therapy 3 times a week for 10 consecutive weeks at our traditional Chinese medicine ward.

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This is a retrospective cohort study by analyzing a multi-institutional electronic medical records database in Taiwan to compare long-term effectiveness and risk of major adverse cardiac events (MACE) in chemotherapy-naïve metastatic castration-resistant prostate cancer (mCRPC) patients treated with enzalutamide (ENZ) or abiraterone (AA). Patients aged 20 years and older and newly receiving androgen receptor targeted therapies ENZ or AA from September 2016 to December 2019 were included. We followed patients from initiation of therapies to the occurrence of outcomes (prostate-specific antigen (PSA) response rate, PSA progression free survival (PFS), overall survival (OS), and MACE), death, the last clinical visit, or December 31, 2020.

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Background: Prognosis of metastatic BRAF V600E mutant colorectal cancer (CRC) is poor, and the prognostic implications of immune contextures in the tumour microenvironment (TME) for CRC remain elusive.

Methods: We collected the primary tumour specimens and clinicopathological characteristics of patients with de novo metastatic microsatellite-stable BRAF V600E mutant CRC from two medical centres. Gene expression analysis was performed using the nCounterⓇ PanCancer Immune Profiling Panel.

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Article Synopsis
  • High-order harmonic generation (HHG) is a key method for producing short-wave coherent light sources by interacting ultra-intense lasers with atoms.
  • The paper focuses on improving the accuracy of quantum simulations of HHG in hydrogen atoms using a time-series prediction scheme, enhanced by neural networks.
  • The proposed method can be applied to complex multi-electron systems, enabling fast and precise simulations of their nonlinear dynamics when exposed to intense laser pulses.
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  • - Immune checkpoint inhibitors (ICIs) are effective as a first treatment for patients with metastatic urothelial carcinoma who cannot receive cisplatin, but it's unclear whether they work better alone or with chemotherapy.
  • - A study analyzing 130 patients revealed that those receiving ICI alone had a median overall survival of 19.5 months, compared to 9.7 months for those receiving ICIs with chemotherapy.
  • - Patients with tumors expressing high levels of programmed cell death ligand-1 showed even better outcomes with ICI monotherapy, suggesting that combining ICI with noncisplatin chemotherapy does not enhance results.
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  • This study investigates how the location of tumors (renal pelvis vs. ureter) affects cancer outcomes for patients with upper tract urothelial carcinoma (UTUC) who underwent radical surgery between 2005 and 2019.
  • A total of 302 patients were analyzed, focusing on outcomes like recurrence and survival rates, with findings indicating that ureteral tumors correlated with worse rates of local recurrence.
  • The research concludes that tumor location is a significant factor in prognosis for UTUC, suggesting the need for further studies to explore underlying biological reasons for these disparities.
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  • The study aimed to explore how galectin-1 and galectin-3 levels in tumors affect survival outcomes in lung adenocarcinoma patients following radiation therapy.
  • Out of 41 patients, galectin-1 was overexpressed in 26.8% and galectin-3 in 19.5%, with galectin-1 linked to worse locoregional progression-free survival (LRPFS) in both statistical analyses.
  • The results suggest that high levels of galectin-1 are associated with poorer survival outcomes, while galectin-3 did not show a significant impact; further investigation into the role of galectin-1 in radiation response is recommended.
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