Publications by authors named "Su-Yeon Gu"

Article Synopsis
  • - High salt intake, specifically from mineral-rich sea salt, can lead to several health issues; this study explored its effects on male rats compared to a normal diet.
  • - Rats fed diets with 1% or 4% sea salt experienced weight loss, changes in gut salt content, and shifts in beneficial and harmful gut bacteria, which may affect gut health.
  • - The study found significant alterations in female hormones and reductions in certain compounds related to kidney function due to high sea salt intake, suggesting that these physiological changes might vary by sex.
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Background: The A20 ubiquitin-editing enzyme is a target of nuclear factor kappa B (NF-κB) and also plays a key role in regulating the NF-κB signaling pathway. NF-κB activity is increased during human cytomegalovirus (HCMV) infection and HCMV appears to be adapted to this change. To better understand the regulation of NF-κB signaling during HCMV infection, we investigated how A20 expression is controlled during HCMV infection.

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The interferon-inducible Sp100 proteins are thought to play roles in the chromatin pathway and in transcriptional regulation. Sp100A, the smallest isoform, is one of the major components of PML nuclear bodies (NBs) that exhibit intrinsic antiviral activity against several viruses. Since PML NBs are disrupted by the immediate-early 1 (IE1) protein during human cytomegalovirus (HCMV) infection, the modulation of Sp100 protein expression or activity during infection has been suggested.

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