Publications by authors named "Su-Ya Xi"
[Matrix metalloproteinase-1 gene -519A/G polymorphism and the risk of coronary heart disease in Northern Chinese Han population].
Zhonghua Xin Xue Guan Bing Za Zhi
March 2008
Objective: To investigate the relationship between matrix metalloproteinase (MMP) 1 gene -519A/G polymorphism and the risk of coronary heart disease (CHD) in Northern Chinese Han population.
Methods: A total of 517 patients with CHD and 380 healthy adults diagnosed by coronary angiography were genotyped by polymerase chain reaction-restriction fragment length polymorphism and DNA sequence technology for the -519A/G polymorphism in MMP1 gene.
Results: (1) The frequency of AA genotype was significantly higher in patients with CHD than that in controls [67.
Article Synopsis
- The study aims to analyze the link between the CX37 C1019T gene variation and the risk of coronary artery disease (CAD) in the northern Han population of China.
- It included 514 CAD patients and 400 healthy individuals, showing that the C allele of the CX37 gene was significantly more common in CAD patients compared to controls, indicating a greater risk of developing the disease.
- The findings suggest that the C allele is linked to increased susceptibility to CAD, particularly in males, while no significant difference was found in females regarding the same risk.