BALF editome profiling reveals A-to-I RNA editing associated with severity and complications of pneumonia in children.

is an important human respiratory pathogen that causes mild-to-moderate community-acquired pneumonia (MPP), particularly in children. RNA editing plays a vital role in pathogen infection and host immune response, but it remains largely unknown how it could be involved in the epigenetic regulation of host response to infection. In the present study, we performed an epitranscriptomic analysis of adenosine to inosine (A-to-I) editing in 39 bronchoalveolar lavage fluid (BALF) samples from the severe side (SS) and the opposite side (OS) of patients with MPP.