Extract of promotes neuronal regeneration in the hippocampus after exposure to acrylamide.

Previous studies have demonstrated a neuroprotective effect of extract of against neuronal damage, but have mainly focused on antioxidation of extract of . To date, limited studies have determined whether extrasct of has a protective effect on neuronal damage. In the present study, acrylamide and 30, 60, and 120 mg/kg extract of were administered for 4 weeks by gavage to establish mouse models.

Protective effects of components of the Chinese herb grassleaf sweetflag rhizome on PC12 cells incubated with amyloid-beta42.

The major ingredients of grassleaf sweetflag rhizome are β-asarone and eugenol, which can cross the blood-brain barrier and protect neurons. This study aimed to observe the neuroprotective effects and mechanisms of β-asarone and eugenol, components of the Chinese herb grassleaf sweetflag rhizome, on PC12 cells. First, PC12 cells were cultured with different concentrations (between 1 × 10(-10) M and 1 × 10(-5) M) of β-asarone and eugenol.

Acrylamide neurotoxicity on the cerebrum of weaning rats.

The mechanism underlying acrylamide-induced neurotoxicity remains controversial. Previous studies have focused on acrylamide-induced toxicity in adult rodents, but neurotoxicity in weaning rats has not been investigated. To explore the neurotoxic effect of acrylamide on the developing brain, weaning rats were gavaged with 0, 5, 15, and 30 mg/kg acrylamide for 4 consecutive weeks.