Publications by authors named "Su-Min Sun"
Pharmacol Res
November 2020
Article Synopsis
- - Endoplasmic reticulum (ER) stress in chronic liver disease leads to the accumulation of misfolded proteins, triggering an unfolded protein response (UPR) that regulates protein degradation systems like the ubiquitin-proteasome system (UPS) and autophagy.
- - UPR activates various transcription factors that enhance the expression of genes related to UPS and autophagy, helping cells cope with ER stress and preventing cell death (apoptosis).
- - Understanding the role of protein degradation in chronic liver diseases (like NAFLD and HCC) opens up potential treatment strategies, where either promoting or inhibiting this process may be beneficial for patients.
