Publications by authors named "Su-Mei Lai"
Background: Numerous prior studies have extensively highlighted the significance of the microbiome in association with asthma. While several studies have concentrated on the asthma microbiome in previous research, there is currently a lack of publications that employ bibliometric methods to assess this area.
Methods: In this study, the Web of Science Core Collection database was utilized as the data source, and the SCI-EXPANDED index was employed to ensure that the retrieved data were comprehensive and accurate.
Article Synopsis
- Clinical evidence points to a connection between pulmonary hypertension (PH) and coronary artery (CA) disease, with serotonin, reactive oxygen species, and calcium signaling being crucial factors in this relationship.
- A study on rats indicates that the NOX-TRPM2 pathway plays a significant role in the remodeling of coronary arteries associated with pulmonary hypertension.
- Findings show that NOX1/4 and TRPM2 contribute to increased cell proliferation and metabolic changes in CA smooth muscle cells, ultimately leading to mitochondrial dysfunction, but inhibiting NOX1/4 can mitigate these effects.
Background: Pulmonary arterial hypertension maintains rapid cell proliferation and vascular remodeling through metabolic reprogramming. Recent studies suggested that circRNAs play important role in pulmonary vascular remodeling and pulmonary arterial smooth muscle cells proliferation. However, the relationship between circRNA, cell proliferation, and metabolic reprogramming in pulmonary arterial hypertension has not been investigated.
View Article and Find Full Text PDFNew Findings: What is the central question of this study? What is the involvement of Mg in mitigating the vasoconstriction in pulmonary arteries and smaller pulmonary arteries in the monocrotaline-induced pulmonary arterial hypertension (MCT-PAH) rat model? What are the main finding and its importance? Both store-operated Ca entry- and receptor-operated Ca entry-mediated vasoconstriction were enhanced in the MCT-PAH model. High magnesium inhibited vasoconstriction by directly antagonizing Ca and increasing NO release, and this was more notable in smaller pulmonary arteries.
Abstract: Increased extracellular magnesium concentration has been shown to attenuate the endothelin-1-induced contractile response via the release of nitric oxide (NO) from the endothelium in proximal pulmonary arteries (PAs) of chronic hypoxic mice.
Objectives: To detect the vascular tension and nitric oxide (NO) release synchronously in mice pulmonary artery, we perform two experiments and present a novel application of confocal wire myograph coupled with the confocal laser scanning microscopy.
Methods: In the first experiment, viable endothelium-intact mouse pulmonary artery (outer diameter 100-300 μM) rings underwent a one-hour preincubation with a NO-specific fluorescent dye, 4-amino-5-methylamino-2',7'-difluorofluorescein diacetate Calbiochem (2.5 μM), and then precontracted with phenylephrine (Phen, 10 M), and subsequently dilated in acetylcholine (ACh, 10 M - 10 M).