microRNA-378b regulates ethanol-induced hepatic steatosis by targeting CaMKK2 to mediate lipid metabolism.

Alcoholic liver disease (ALD) has seriously harmed the health of people worldwide, but its underlying mechanisms remain unclear. This study aims to clarify the biological function of microRNA-378b (miR-378b) in ethanol (EtOH)-induced hepatic lipid accumulation. Here, we report miR-378b is over-expressed in EtOH-induced cells and EtOH-fed mice and finally accelerates lipid accumulation.

A Real-Time Fluorescent Reverse Transcription Quantitative PCR Assay for Rapid Detection of Genetic Markers' Expression Associated with Fusarium Wilt of Banana Biocontrol Activities in .

Fusarium wilt of banana, caused by f. sp. (), especially Tropical Race 4 (TR4), seriously threatens banana production worldwide.

New Disubstituted Quindoline Derivatives Inhibiting Burkitt's Lymphoma Cell Proliferation by Impeding c-MYC Transcription.

The c-MYC oncogene is overactivated during Burkitt's lymphoma pathogenesis. Targeting c-MYC to inhibit its transcriptional activity has emerged as an effective anticancer strategy. We synthesized four series of disubstituted quindoline derivatives by introducing the second cationic amino side chain and 5-N-methyl group based on a previous study of SYUIQ-5 (1) as c-MYC promoter G-quadruplex ligands.

Surface plasmon enhanced up-conversion from NaYF4:Yb/Er/Gd nano-rods.

The surface plasmons that are enabled by grating coupling in two-dimensional gold nano-particle arrays (AuNPAs) affected the spectral characteristics of the up-conversion (UC) emission from Yb(3+)-Er(3+)-Gd(3+) co-doped sodium yttrium fluoride (NaYF4:Yb/Er/Gd) nano-rods. The red emission of NaYF4:Yb/Er/Gd nano-rods at 660 nm (excited with a 980 nm diode laser) was significantly enhanced by the interaction with the AuNPAs. The geometric characteristics of the gold nanoparticles influenced the position of the surface plasmon resonance, and their near field strengths.