Publications by authors named "Su-Ke Sun"
Article Synopsis
- The study aimed to create a population pharmacokinetic (PK) model for ciprofol and its major metabolite, M4, and connect it to a pharmacodynamic (PD) model for subjects with different kidney functions.
- A three-compartment model effectively described the PK of unbound ciprofol, and a two-compartment model was suitable for M4, with hemoglobin and uric acid influencing drug clearance.
- The findings concluded that the developed model accurately represents ciprofol's PK and PD, indicating no need for dosage changes in patients with mild to moderate renal impairment.
[Prognostic significance of coagulation disorders in children with hemophagocytic syndrome].
Zhongguo Dang Dai Er Ke Za Zhi
May 2014
Objective: To study the prognostic significance of coagulation disorders in children with hemophagocytic syndrome (HPS).
Methods: Thirty-five children with HPS were retrospectively studied to analyze the etiology, clinical characteristics, laboratory results and treatment outcomes.
Results: After treatment, 27 of the 35 HPS patients survived, and the other 8 cases died.