Publications by authors named "Su-Jeen Jung"
Article Synopsis
- Sarcopenia is the age-related loss of muscle mass and function, significantly impacting health as the population ages.
- Mitochondrial dysfunction, particularly through mitochondrial reactive oxygen species (mtROS), plays a critical role in sarcopenia, and resistance exercise training (RET) may be beneficial despite traditional views favoring aerobic exercise for improving mitochondria.
- This review explores how RET can positively influence mtROS, enhance mitochondrial biogenesis, improve mitochondrial dynamics, and promote mitophagy in aging muscles, offering strategies to combat sarcopenia and maintain muscle health.
A decline in estrogen levels during menopause is associated with the loss of muscle mass and function, and it can accelerate sarcopenia. However, with the growing number of postmenopausal women due to the increase in life expectancy, the effects of estrogen on skeletal muscle are not completely understood. This article reviews the relationship between estrogen deficiency and skeletal muscle, its potential mechanisms, including those involving mitochondria, and the effects of exercise on estrogen deficiency-induced skeletal muscle impairment.
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- The study investigates the impact of different doses of cisplatin, an anti-cancer drug, on skeletal muscle mitochondrial function and autophagy-related protein levels in rats.
- Male Wistar rats were divided into three groups: one received a saline placebo, while the others received low (0.1 mg/kg) and high (0.5 mg/kg) doses of cisplatin.
- The high-dose group showed decreased body weight and muscle tissue, impaired mitochondrial function, and increased levels of autophagy proteins, indicating that high doses of cisplatin may lead to muscle atrophy and dysfunction.
The purpose of this study is to determine whether moderate aerobic exercise training improves high-fat diet-induced alterations in mitochondrial function and structure in the skeletal muscle. Male 4-week-old C57BL/6 mice were randomly divided into four groups: control (CON), control plus exercise (CON + EX), high-fat diet (HFD), and high-fat diet plus exercise (HFD + EX). After obesity was induced by 20 weeks of 60% HFD, treadmill exercise training was performed at 13-16 m/min, 40-50 min/day, and 6 days/week for 12 weeks.
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- Statins, like atorvastatin, can help prevent heart disease but may cause muscle issues and mitochondrial problems.
- A study with Wistar rats found that combining atorvastatin treatment with aerobic exercise improved glucose tolerance, muscle strength, and reduced muscle damage compared to rats only on atorvastatin.
- Exercise training also appears to help preserve mitochondrial function and increase certain protective proteins in the muscles affected by atorvastatin.
The effects of heliox non-saturation diving on the cardiovascular system and cognitive functions.
Undersea Hyperb Med
January 2021
The purpose of this study was to investigate the effects of a single bout of heliox non-saturation diving on the cardiovascular system and cognitive function. Ten recreational scuba divers (10 males, ∼35 years old) participated in this study. These subjects made two pool dives within a one-week interval, alternating gases with compressed air (21% O2, 79% N2) and with heliox (21% O2 and 79% He).
View Article and Find Full Text PDFThis study aimed to determine the effects of a single bout exercise on mitochondria-mediated apoptotic signaling in cardiac and skeletal muscles. Fischer 344 rats (4 months old) were randomly divided into the control or a single bout of exercise group (n=10 each). The rats performed a single bout of treadmill exercise for 60 min.
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- - This study examined how a single session of exercise impacts mitochondrial function, dynamics, and mitophagy in the heart and skeletal muscles of Fischer 344 rats.
- - The rats that exercised showed improved mitochondrial oxygen respiration and calcium retention, but mitochondrial fusion and fission were unchanged, with varied effects on mitophagy across different muscle types.
- - The findings suggest that aerobic exercise enhances certain aspects of mitochondrial function without affecting the overall dynamics or the process of cleaning up damaged mitochondria.
Exercise Training Attenuates Obesity-Induced Skeletal Muscle Remodeling and Mitochondria-Mediated Apoptosis in the Skeletal Muscle.
Int J Environ Res Public Health
October 2018
Article Synopsis
- Obesity leads to changes in skeletal muscle and increased apoptosis (cell death) associated with mitochondria, which can negatively affect muscle function.
- A study used four groups of mice to examine how exercise influences muscle structure and cell death in the context of obesity induced by a high-fat diet.
- The findings indicate that exercise helps improve muscle structure and reduces apoptosis in obese mice, highlighting its potential protective effects on skeletal muscle health.
Arterial stiffness is inversely associated with a better running record in a full course marathon race.
J Exerc Nutrition Biochem
December 2014
Purpose: Arterial stiffness is an independent predictor of cardiovascular risk and may contribute to reduced running capacity in humans. This study investigated the relationship between course record and arterial stiffness in marathoners who participated in the Seoul International Marathon in 2012.
Methods: A total of 30 amateur marathoners (Males n = 28, Females n = 2, mean age = 51.