Publications by authors named "Su-Hee Hwang"
Article Synopsis
- Autoinhibition is a key self-regulation mechanism in cell signaling that ensures signals only pass through in the presence of specific inputs, making autoinhibited proteins relevant in human diseases as potential targets for therapy.
- The newly established Autoinhibited Protein Database (AiPD) compiles standardized information on autoinhibited proteins, including details on autoinhibitory domains, their targets, and their roles in diseases.
- AiPD features a significant collection of both experimentally characterized and computationally predicted autoinhibited proteins, making it a crucial resource for researchers focusing on autoinhibition mechanisms and drug discovery.
Analysis methods for the gut microbiome in neuropsychiatric and neurodegenerative disorders.
Comput Struct Biotechnol J
February 2022
For a long time, the central nervous system was believed to be the only regulator of cognitive functions. However, accumulating evidence suggests that the composition of the microbiome is strongly associated with brain functions and diseases. Indeed, the gut microbiome is involved in neuropsychiatric diseases (e.
View Article and Find Full Text PDFDifferentiation of oligodendrocytes (ODs) presents a challenge in regenerative medicine due to their role in various neurological diseases associated with dysmyelination and demyelination. Here, we designed a peptide derived from vitronectin (VN) using in silico docking simulation and examined its use as a synthetic substrate to support the differentiation of ODs derived from human pluripotent stem cells. The designed peptide, named VNP2, promoted OD differentiation induced by the overexpression of SOX10 in OD precursor cells compared with Matrigel and full-length VN.
View Article and Find Full Text PDF