Publications by authors named "Su-Bin Liao"
Article Synopsis
- Levonorgestrel (LNG) is primarily used as an emergency contraceptive by delaying ovulation, and this study aimed to explore its effects on the human Fallopian tube's ciliary movement and muscle contractions.
- In an experimental setup using tissue samples from women, the researchers tested LNG at various concentrations to see any changes in ciliary beat frequency and muscular contractions.
- Results showed that while LNG did not significantly affect ciliary movement or muscle tone, the highest concentration (100 ng/ml) did reduce muscular contractions, indicating that the Fallopian tube is not likely a target for LNG's contraceptive effects at typical emergency contraception doses.
Background: The occurrence of tubal ectopic pregnancy (tEP) is related to the inflammation of the oviduct. Recently, Adrenomedullin (ADM) was found highly expression in human oviduct. The current study is to investigate whether ADM have a modulatory action on inflammatory cytokines and chemokines in oviductal tissue from women with tubal ectopic pregnancy (tEP).
View Article and Find Full Text PDFStudy Question: Do ulipristal acetate (UPA) and mifepristone have an effect on ciliary beat frequency and muscular contractions in the human Fallopian tube?
Summary Answer: UPA, in resemblance to mifepristone, inhibits ciliary beat and muscular contraction of the human Fallopian tube, probably through an agonistic effect on the tubal progesterone receptor.
What Is Known Already: UPA, like mifepristone, acts as an emergency contraceptive mainly by inhibiting ovulation. Little is known about its effects on tubal function.
Objective: To study adrenomedullin (ADM) expression and its relation to ciliary beat frequency (CBF) in the nasal mucociliated epithelium in tubal ectopic pregnancy (tEP).
Design: Experimental study.
Setting: University teaching hospital.
Possible functions of adrenomedullin from the seminal fluid in the female reproductive tract of the rat.
Syst Biol Reprod Med
December 2012
Adrenomedullin (ADM) is found in male accessory sex glands and is part of the seminal secretion. It plays an important role in protecting the sperm in the female reproductive tract. In this study, we investigated the roles of ADM in inflammation and oxidative stress in the endometrium and in leukocyte and macrophage infiltration in the endometrial stroma.
View Article and Find Full Text PDFWe previously reported that the male accessory sex gland (ASG) secretion is the main source of antioxidants to safeguard sperm genomic integrity and functional competence. Removal of all ASGs in the golden hamster can reduce male fertility by increasing embryo wastage. This study aims to investigate whether the oxidative DNA-damaged sperm from hamsters without all ASGs (TX) could successfully fertilize oocytes and to qualify the status of DNA repair by the expression of RAD51 and p53 proteins.
View Article and Find Full Text PDFObjective: To investigate the effect of adrenomedullin (ADM) on seminal vesicle smooth muscle contractions in the rat and the specific receptor involved. Whether it was dependent on the nitric oxidant pathway was also investigated.
Methods: The seminal vesicles from Sprague-Dawley rats aged 8-10 weeks were incubated in Kreb's solution.