In vivo functional effects of VP30 exopolysaccharides on loperamide-induced constipation in rats.

In this work, the in vivo functionalities of milk fermented with VP30 (VP30-EPS) and purified exopolysaccharide (pEPS) from the milk fermented with VP30 were evaluated for their effect on constipation using an experimental constipated rat model. Rats were randomly divided into four groups: (i) control group (PBS administered normal group), (ii) loperamide treated group (constipation group), (iii) constipation with loperamide plus VP30-EPS (1 g/kg), and (iv) constipation with loperamide plus pEPS (0.6 g/kg) groups.

Finger Vein Verification on Different Datasets Based on Deep Learning with Triplet Loss.

In this study, deep learning and triplet loss function methods are used for finger vein verification research, and the model is trained and validated between different kinds of datasets including FV-USM, HKPU, and SDUMLA-HMT datasets. This work gives the accuracy and other evaluation indexes of finger vein verification calculated for different training-validation set combinations and gives the corresponding ROC curves and AUC values. The accuracy of the best result has reached 98%, and all the ROC AUC values are above 0.

Emotional-Health-Oriented Urban Design: A Novel Collaborative Deep Learning Framework for Real-Time Landscape Assessment by Integrating Facial Expression Recognition and Pixel-Level Semantic Segmentation.

Emotional responses are significant for understanding public perceptions of urban green space (UGS) and can be used to inform proposals for optimal urban design strategies to enhance public emotional health in the times of COVID-19. However, most empirical studies fail to consider emotion-oriented landscape assessments under dynamic perspectives despite the fact that individually observed sceneries alter with angle. To close this gap, a real-time sentimental-based landscape assessment framework is developed, integrating facial expression recognition with semantic segmentation of changing landscapes.

Prediction of Cervical Lymph Nodes Metastasis in Papillary Thyroid Carcinoma (PTC) Using Nodal Staging Score (NSS).

Background: Cervical lymph node metastasis is commonly seen in papillary thyroid carcinoma. Surgery is the preferred treatment for PTC with cervical lymph node metastasis. There is no alternate ultrasound, neck CT, and thyroglobulin (Tg) methods to assess the occult lymph node metastasis.

E2F1-induced long non-coding RNA MCF2L-AS1 modulates Cyclin D1 mRNA stability through ELAVL1 to induce Gefitinib resistance in non-small cell lung cancer.

Purpose: Gefitinib is a widely used therapeutic drug for non-small cell lung cancer (NSCLC), and its acquired resistance has become one of the barriers to the successful use of the drugs to treat NSCLC patients. Long non-coding RNA (lncRNA) has an essential role in developing cancer drug resistance. Hence, this study aimed to investigate the effect and modulatory mechanisms of lncRNA MCF2L-AS1 in Gefitinib resistance in NSCLC.

Dynamic Epitaxial Growth of Organic Heterostructures for Polarized Exciton Conversion.

Highly spatial and angular precision in epitaxial-growth process is crucial for constructing organic low-dimensional heterostructures (OLDHs) with the desired substructures, which remains significant challenge owing to the unpredicted location of complex heterogeneous nucleation. Herein, a dynamic epitaxial-growth approach is developed along the tailored longitudinal/horizontal directions to create diverse OLDHs with hierarchical architectures. The controlled morphology evolution of seed crystals from kinetic to thermodynamic species is achieved via incrementally increasing the crystallization time from 0 to 600 s.

Differential expression and roles of Huntingtin and Huntingtin-associated protein 1 in the mouse and primate brains.

Huntingtin-associated protein 1 (HAP1) is the first identified protein whose function is affected by its abnormal interaction with mutant huntingtin (mHTT), which causes Huntington disease. However, the expression patterns of Hap1 and Htt in the rodent brain are not correlated. Here we found that the primate HAP1, unlike the rodent Hap1, is correlatively expressed with HTT in the primate brains.

QoS based enhanced lossless contention MAC protocol for ultraviolet network.

Ultraviolet (UV) communication, with its excellent characteristics of non-line-of-sight propagation, high confidentiality, and flexible networking, has gradually gained traction in the field of research. The UV media access control (MAC) protocol is relatively lacking at present, and the UV lossless contention MAC (UVLLC-MAC) protocol designed by our team earlier is limited by the predictability of communication network topology; hence, it is not applicable to multinode and multi-data networks. In order to be applicable to multinode network and satisfy the quality of service (QoS) for various data, an enhanced UVLLC-MAC (eUVLLC-MAC) protocol is proposed based on the binary exponential backoff (BEB) and UVLLC protocols.

The Evolutionary Game Analysis of Low Carbon Production Behaviour of Farmers, Government and Consumers in Food Safety Source Governance.

Whether the quality of agricultural products is safe or not is related to issues of food safety and low carbon production in agriculture. Based on evolutionary game theory, this paper establishes a game model among government, farmers and consumers and analyzes the dynamic evolutionary process and evolutionary stable strategies of the major stakeholders. The results show that: (i) government subsidy coefficient, farmers' penalty coefficient for not producing, consumer trust coefficient and willingness to pay carbon labelled agricultural products premium are positively related to farmers' adoption of low-carbon production behaviour, and fraud penalty coefficient and farmers' cost of adopting low-carbon production technology are negatively related; (ii) farmers' sensitivity to government regulation policies is: fraud penalty coefficient = farmers' cost of adopting low-carbon production technology > government subsidy The sensitivity of farmers to government regulation policies is: fraud penalty coefficient = cost of low-carbon production technology > government subsidy > penalty coefficient for non-production, and the sensitivity of farmers to direct market stimulation is: consumer trust coefficient > coefficient of willingness to pay premium for carbon labelled agricultural products, and the additional benefit coefficient has no significant effect on farmers' decision-making; (iii) In the early stage, the source control of food safety mainly depends on the government's policy intervention.

Development and validation of a prediction model for preoperative anxiety in children aged 2-12 years old.

Background: Children with preoperative anxiety are at risk of perioperative adverse events, such as reflux aspiration, prolonged induction time, wake agitation, and delirium. Identifying children at high risk of severe preoperative anxiety may help anesthesiologists intervene and manage them in advance.

Aim: The authors hypothesized that the risk of developing serious preoperative anxiety in children is predictable by variables related to basic information about the parent and child.

The impact of CoronaVac on the neutralization breadth and magnitude of the antibody response to SARS-CoV-2 viruses.

Although immune response enhancement has been reported after primary and booster vaccines of CoronaVac, neutralization breadth of SARS-CoV-2 variants is still unclear. In the present study, we examined the neutralization magnitude and breadth of SARS-CoV-2 variants including Beta (B.1.

Burnout, negative emotions, and wellbeing among social workers in China after community lockdowns during the COVID-19 pandemic: Mediating roles of trait mindfulness.

Objective: This study aimed to investigate burnout situation of social workers (SWs) who experienced the COVID-19 pandemic-related community lockdown 1 year before, and to assess the protective value of trait mindfulness (TM) in states of burnout.

Method: We surveyed the burnout, trait mindfulness, negative emotions (NEs) and wellbeing (WB) of 182 social workers provided services to Wuhan lockdowns community by COVID-19 one year before. Burnout were measured using the Maslach Burnout Inventory-Human Services Survey; TM using the Mindful Attention Awareness Scale; NEs using the Depression Anxiety and Stress Scale-21; and WB using the General Wellbeing Schedule.

Clinical features and prognostic factors in patients with microvascular infiltration of hepatocellular carcinoma: Development and validation of a nomogram and risk stratification based on the SEER database.

Background: The goal is to establish and validate an innovative prognostic risk stratification and nomogram in patients of hepatocellular carcinoma (HCC) with microvascular invasion (MVI) for predicting the cancer-specific survival (CSS).

Methods: 1487 qualified patients were selected from the Surveillance, Epidemiology and End Results (SEER) database and randomly assigned to the training cohort and validation cohort in a ratio of 7:3. Concordance index (C-index), area under curve (AUC) and calibration plots were adopted to evaluate the discrimination and calibration of the nomogram.

Probiotics with anti-type 2 diabetes mellitus properties: targets of polysaccharides from traditional Chinese medicine.

Traditional Chinese medicine polysaccharides is a biologically active ingredient that is not easy to be digested. It is fermented by intestinal microflora to promote qualitative and selective changes in the composition of the intestinal microbiome, which often result in beneficial effects on the health of the host. People call it "prebiotics".

Switchable Tuning CO Hydrogenation Selectivity by Encapsulation of the Rh Nanoparticles While Exposing Single Atoms.

The switch of CO hydrogenation selectivity from CH to CO over TiO supported Rh catalysts is accomplished via selective encapsulation of Rh nanoparticles while exposing Rh single atoms by high-temperature reduction (HTR) according to their different strong metal-support interaction (SMSI) occurrence conditions, which can be reversed by subsequent oxidation treatment.

Reverse shoulder arthroplasty vs. hemiarthroplasty for the treatment of osteoporotic proximal humeral fractures in elderly patients: A systematic review and meta‑analysis update.

The present meta-analysis was conducted to compare the safety and effectiveness of reverse shoulder arthroplasty (RSA) and hemiarthroplasty (HA) in the treatment of osteoporotic proximal humeral fractures in elderly patients. The Embase, Pubmed Central, Cumulative Index to Nursing and Allied Health Literature, ProQuest Dissertations and Theses, Cochrane Library and Chinese Biomedical databases were searched between January 2009 and January 2022 to identify relevant studies. According to the search strategy, a total of 210 associated studies were retrieved and 16 were finally included.

New insight into the current study of high tibial osteotomy: A bibliometric analysis.

Background: To analyze global trends in focus and funding of research related to high tibial osteotomy (HTO) and to identify the 100 most cited articles in this field.

Methods: A Web of Science search was used to identify HTO publications in English-language scientific journals from January 1967 till February 3th, 2021. Results were filtered to the 100 most cited articles by reading the abstract or full-text paper.

Experimental Study of the Influence of H/CO on the CH Explosion Pressure and Thermal Behaviors.

In a spontaneous coal combustion environment and in the coal chemical process, multiple gases, such as CH, H, and CO, coexist, and explosion accidents are prone to occur. The causes of these disasters and the explosion characteristics are key to formulating preventive measures. To explore the effect of H/CO on the explosion pressure and thermal behavior of methane-air, CH with initial volume fractions of 7, 9.

IL-33 Participates in the Development of Esophageal Adenocarcinoma.

The progression from chronic gastroesophageal reflux disease (GERD) to Barrett esophagus (BE) and esophageal adenocarcinoma (EAC) is an inflammatory-driven neoplastic change. Interleukin-33 (IL-33) has identified as a crucial factor in several inflammatory disorders and malignancies. The high-density tissue microarray of the human EAC was analyzed with IL-33 immunohistochemistry staining (IHC).

Projecting the impact of implementation of WHO MPOWER measures on smoking prevalence and mortality in Japan.

Objective: This study aimed to quantify the long-term impact of implementing the WHO Framework Convention on Tobacco Control (FCTC) compliant tobacco control measures, MPOWER, on smoking prevalence and mortality in men and women aged ≥20 years in Japan.

Design: A Stock-and-Flow simulation model was used to project smoking prevalence and mortality from 2018 to 2050 under eight different scenarios: (1) maintaining the 2018 status quo, (2) implementation of smoke-free policies, (3) tobacco use cessation programmes, (4-5) health warning about the dangers of tobacco (labels, mass media), (6) enforcement of tobacco advertising bans or (7) tobacco taxation at the highest recommended level and (8) all these interventions combined.

Results: Under the status quo, the smoking prevalence in Japan will decrease from 29.

Nanobodies and chemical cross-links advance the structural and functional analysis of PI3Kα.

Nanobodies and chemical cross-linking were used to gain information on the identity and positions of flexible domains of PI3Kα. The application of chemical cross-linking mass spectrometry (CXMS) facilitated the identification of the p85 domains BH, cSH2, and SH3 as well as their docking positions on the PI3Kα catalytic core. Binding of individual nanobodies to PI3Kα induced activation or inhibition of enzyme activity and caused conformational changes that could be correlated with enzyme function.

Function Mechanism of Psychological Driving Factors and Professional Transformation: Migrant Workers to Industrial Workers.

With in-depth development of industrialization and urbanization in China, improving the professional skills and quality of migrant workers in the construction industry has become an important measure to optimize the labor force structure and promote the industry upgrading. Numerous studies have been carried out on this topic, and construction industrial workers with high skills level and professional quality have replaced the professional identity of migrant workers. However, the psychological cognitive mechanism of migrant workers' occupational role enhancement behavior has not been fully revealed.

miR-10a-5p inhibits chicken granulosa cells proliferation and Progesterone(P4) synthesis by targeting MAPRE1 to suppress CDK2.

The proliferation and steroid hormone synthesis of granulosa cells (GCs) are essential for ovarian follicle growth and ovulation, which are necessary to support the normal function of the follicle. Numerous studies suggest that miRNAs play key roles in this process. In this study, we report a novel role for miR-10a-5p that inhibits ovarian GCs proliferation and progesterone (P4) synthesis in chicken.

Interpretation discrepancies of abdominal imaging by on-call radiology residents: Evaluation of risk factors.

The aim of this study was to determine the rate, important findings, and risk factors related to discrepancies between on-call residents' and attending radiologists' interpretations of abdominal examinations. We identified 1132 eligible patients with abdominal radiology findings that were preliminary interpreted by on-call residents between February 2016 and September 2019. The preliminary interpretations were compared with the final interpretations by abdominal attending radiologists, including clinical data.

Immunoglobulin Superfamily Containing Leucine-Rich Repeat (Islr) Participates in IL-6-Mediated Crosstalk between Muscle and Brown Adipose Tissue to Regulate Energy Homeostasis.

Brown adipose tissue (BAT) is functionally linked to skeletal muscle because both tissues originate from a common progenitor cell, but the precise mechanism controlling muscle-to-brown-fat communication is insufficiently understood. This report demonstrates that the immunoglobulin superfamily containing leucine-rich repeat (Islr), a marker of mesenchymal stromal/stem cells, is critical for the control of BAT mitochondrial function and whole-body energy homeostasis. The mice loss of Islr in BAT after cardiotoxin injury resulted in improved mitochondrial function, increased energy expenditure, and enhanced thermogenesis.