Publications by authors named "Su Varma"

The utilization of transthoracic approaches for the repair of large hiatus hernias remains a topic of clinical debate. This study aims to evaluate the efficacy, safety, and recovery metrics for transthoracic hiatal hernia repair. A literature search was conducted using the key terms "hiatus hernia," "thoracotomy," "thoracic approach," and "Belsey Mark IV.

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Background: Greater unhelpful thinking is associated with greater musculoskeletal discomfort and incapability. Cognitive-behavioral therapy (CBT) fosters healthy thinking to help alleviate symptoms.

Questions: In a meta-analysis of randomized control trials (RCT) of CBT for unhelpful thinking among people with musculoskeletal symptoms, we asked: 1) Does CBT reduce unhelpful thinking and feelings of distress, and improve capability, in individuals with musculoskeletal symptoms? 2) Are outcomes affected by CBT delivery methods?

Methods: Following QUOROM guidelines, we searched databases using keywords of pain catastrophizing, kinesiophobia, cognitive-behavioral therapy, musculoskeletal and variations.

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Primary spinal intradural malignant peripheral nerve sheath tumors (MPNSTs) are rare neoplasms, especially in children with a non-neurofibromatosis background. Scarce pediatric data exist with regard to such tumors. A 4-year-old child with a history of spastic limb weakness was operated for a foramen magnum spinal lesion (intradural and extradural) with imaging suggestive of schwannoma; the histopathology, however, was that of a MPNST.

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  • A study was conducted to investigate the X-chromosome's role in Alzheimer's Disease (AD), which had been overlooked in previous genome-wide association studies.
  • The research included 115,841 AD cases and 613,671 controls, considering different X-chromosome inactivation (XCI) states in females.
  • While no strong genetic risk factors for AD were found on the X-chromosome, seven significant loci were identified, suggesting areas for future research.
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• RV volume overload causes septal flattening which leads to reduced transmitral flow. • In severe TR, MVA calculated by Doppler techniques is unreliable. • In MS with concomitant TR, 3D MPR planimetry is reliable for MVA calculation.

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Myoepitheliomal tumours, associated with the salivary glands and certain soft tissue sites, are unusually encountered in the central nervous system (CNS). In the brain, although the most common location is the Sella, other areas can infrequently be involved. Such intracranial lesions are exceptionally rare in children.

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Introduction: Neonates with congenital diaphragmatic hernia (CDH) who undergo repair while on extracorporeal membrane oxygenation (ECMO) are at risk of developing post-operative bleeding complications. Balanced anticoagulation is critical to maintain ECMO flow and avoid bleeding. Heparin has historically been our first-line anticoagulant; however, recently, we transitioned to bivalirudin, a direct thrombin inhibitor.

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  • Tumours can rarely develop at the site of previous appendicectomies, with limited documented cases in medical literature that call for further research.
  • A 20-year-old male was found to have a large abdominal mass two months after it emerged, stemming from an appendectomy performed four years earlier.
  • The tumour was surgically removed and identified as desmoid fibromatosis, highlighting the need for detailed follow-up and histopathological analysis in such cases for better patient care.
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Background: Pretransplant functional, motor, cognitive, and academic deficits are common in pediatric patients requiring heart transplantation (HT); some persist post-HT. We assessed the association between these quality of life (QoL) deficits and post-HT outcomes.

Methods: Using SRTR data 2008-2023, we evaluated the functional, motor, cognitive, and academic status of pediatric HT recipients from listing to 15 years post-HT.

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Post myocardial infarction ventricular septal rupture (MI-VSR) is a dreaded complication, closure of which is extremely challenging. We here describe a case which was surgically closed after 10 days but had a failure needing continuous intra-aortic balloon pump (IABP) support and was subsequently closed percutaneously with a Post MI-VSR device.

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Aim: The purpose of this study was to evaluate the improvement in acoustic and nasalance in patients with maxillary obturators, using PRAAT software.

Materials And Methods: The current study comprised a total of 16 patients who had acquired maxillary defects. Regardless of gender, the age range of these patients was 40-75 years old.

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  • Primary Cardiac Myxofibrosarcoma (PCM) is a rare and aggressive type of heart tumor, often asymptomatic and can be linked to congenital heart defects like Ebstein's anomaly.
  • A case study presented a 38-year-old woman with Ebstein's anomaly who experienced breathing difficulties, leading to the discovery of a mobile cardiac mass that was ultimately diagnosed as PCM after surgical evaluation and histological analysis.
  • The findings emphasize the importance of differentiating PCM from other cardiac masses through detailed pathological studies, as early detection and surgical intervention are crucial for improving outcomes in affected patients.
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Mycetoma of the hand is a chronic granulomatous disease seen in the tropics and subtropical regions, mainly affecting the skin and subcutaneous tissue of the foot. Primary actinomycotic osteomyelitis involving the metacarpals is rarely reported in the literature. The conventional treatment for actinomycosis has been high-dose penicillin.

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  • This text reports a unique case of chronic post-operative endophthalmitis (CPOE) after routine eye surgery, with a gram-positive bacterium identified as the cause.
  • The case involves a 64-year-old man who experienced recurring eye inflammation over six years, initially misdiagnosed but later confirmed through positive vitreous culture.
  • Successful treatment required surgical intervention, including vitrectomy and IOL removal, though the patient suffered vision loss from secondary glaucoma.
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Coronary artery stents protruding into the aorta is a rarely reported problem. Issues with the protruding stent include embolization and interference with aortic valve function. Management of this rare situation should be on an individualized basis.

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  • Posterior ring apophyseal fracture (PRAF) is a rare injury in teens that can cause lower back pain and nerve issues, often due to sports or trauma.
  • A case study highlights a 13-year-old girl with PRAF and lumbar disc herniation after a sports injury, showcasing the diagnostic and surgical challenges.
  • She underwent a minimally invasive surgery and showed significant improvement in pain levels one month later, emphasizing the importance of proper imaging and treatment for similar injuries in adolescents.
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  • The study focuses on the higher incidence of triple-negative breast cancer (TNBC) in India, specifically in Mizoram, and aims to identify novel genetic variants associated with the disease.
  • Researchers analyzed whole exome sequencing data from TNBC patients to uncover significant mutations, finding that TP53 and several other genes were frequently mutated in patients.
  • The research highlighted the presence of novel variants and potential therapeutic targets, suggesting that further exploration of specific genes could lead to advancements in TNBC treatment.
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Background Music therapy has been shown to reduce the need for sedation and analgesics, as well as lower plasma cortisol and epinephrine levels in patients undergoing regional anesthesia. This study evaluates the efficacy of perioperative music therapy in reducing pain perception and its impact on cortisol levels. Materials and methods This prospective randomized control trial was conducted at the tertiary care center in Western Maharashtra.

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The ultimate preferred treatment for hepatocellular carcinoma (HCC) complicated with cirrhosis and portal hypertension is an orthotopic liver transplant (OLT). Loco regional therapy (LRT) has emerged to prevent tumor growth and progression of disease beyond the Milan criteria to achieve transplant. There is a paucity of data regarding safety, posttransplant survival benefits, and tumor recurrence rate achieved by these LRT modalities.

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Introduction: It is estimated that 8% of hospitalised patients require treatment from Interventional Radiology (IR). However, little is known about the potential impact of IR on regional and remote Australians, including Indigenous patients. This study aimed to assess treatments performed by IRs on regional/remote patients to predict future IR workforce and governance needs.

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Background: While REIMS technology has successfully been demonstrated for the histological identification of ex-vivo breast tumor tissues, questions regarding the robustness of the approach and the possibility of tumor molecular diagnostics still remain unanswered. In the current study, we set out to determine whether it is possible to acquire cross-comparable REIMS datasets at multiple sites for the identification of breast tumors and subtypes.

Methods: A consortium of four sites with three of them having access to fresh surgical tissue samples performed tissue analysis using identical REIMS setups and protocols.

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Introduction Ultrasonic bone surgery, or piezosurgery, is a novel technique utilizing ultrasonic vibrations to cut bone while minimizing damage to adjacent soft tissues. This study aims to evaluate the knowledge and awareness of ultrasonic bone surgery among periodontology and oral surgery postgraduate students in Maharashtra, India. Methods A cross-sectional, questionnaire-based study was conducted among 180 postgraduate students (84 in periodontology and 96 in oral surgery).

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