Metabolomic and microbiota profiles in cervicovaginal lavage fluid of women with high-risk human papillomavirus infection.

The presence of high-risk human papillomavirus (HR-HPV) contributes to the development of cervical lesions and cervical cancer. Recent studies suggest that an imbalance in the cervicovaginal microbiota might be a factor in the persistence of HR-HPV infections. In this study, we collected 156 cervicovaginal fluid (CVF) of women with HR-HPV infection, which were divided into three groups (negative for intraepithelial lesions = 78, low/high-grade squamous intraepithelial lesions = 52/26).

Risk assessment of arrhythmias related to three antiseizure medications: a systematic review and single-arm meta-analysis.

Objective: Antiseizure medications (ASMs) are first line therapy for seizure disorders. Their effects on arrhythmias, especially the risk of arrhythmias associated with lacosamide (LCM), levetiracetam (LEV), and perampanel (PER), have been intensely investigated.

Methods: We searched four databases (PubMed, EMBASE, Cochrane Library, and Web of Science) until August 6, 2023.

Superhydrophobic Multifocal Microlens Array with Depth-of-Field Detection for a Humid Environment.

Microlens array (MLA) has been widely applied in augmented reality and optical imaging. When used in a humid environment or medical endoscopy, MLA needs to be both superhydrophobic and multifocal. However, it is not easy to achieve both superhydrophobic and multifocal function by integrating superhydrophobic and multifocal structures on the same surface by means of a simple, efficient, and precise method.

Ultrathin, reflective light-field imaging film realized by self-releasing UV-curable nanoimprinting lithography.

Light-field imaging has emerged as a technology allowing the capture of richer visual information from the world. Ultrathin, reflective light-field imaging film is fabricated by using self-releasing ultraviolet (UV)-curable nanoimprinting lithography. The plenoptic function is built to generate the dense reflective light field in a two-dimension plane in which the occlusion perception can be seamlessly incorporated in the recording process.

Development of a multivariable clinical prediction model for liposomal doxorubicin-induced cardiotoxicity in adult breast cancer patients: a retrospective multicenter study.

Background: The clinical use of anthracyclines is limited by the risk of cardiotoxicity. So, we aim to develop a clinical prediction model for liposomal doxorubicin-induced cardiotoxicity in adult breast cancer patients.

Methods: We designed a multicenter retrospective cohort study.

Endorsement of the TRIPOD statement and the reporting of studies developing contrast-induced nephropathy prediction models for the coronary angiography/percutaneous coronary intervention population: a cross-sectional study.

Objective: Clear and specific reporting of a research paper is essential for its validity and applicability. Some studies have revealed that the reporting of studies based on the clinical prediction models was generally insufficient based on the Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD) checklist. However, the reporting of studies on contrast-induced nephropathy (CIN) prediction models in the coronary angiography (CAG)/percutaneous coronary intervention (PCI) population has not been thoroughly assessed.

Catalytic Performance of Li/Mg Composites for the Synthesis of Glycerol Carbonate from Glycerol and Dimethyl Carbonate.

A series of Li/Mg composites were synthesized by the coprecipitation method using magnesium and lithium nitrates, and then used for the synthesis of glycerol carbonate (GC) from glycerol and dimethyl carbonate (DMC). The experimental results indicated that Li/Mg composites were prospective catalysts for GC synthesis. 92.

Association of Alcohol Drinking and Helicobacter pylori Infection : A Meta-analysis.

Background: The association between drinking and Helicobacter pylori infection was not clear in the literature. Owing to mixed and inconclusive results, a meta-analysis was conducted to summarize and clarify this association systematically.

Methods: Based on a comprehensive search of PubMed, Embase, and Web of Science databases, studies investigating the association between drinking and H.

Experimental Determination of Molecular Weight-Dependent Miscibility of PBAT/PLA Blends.

Blends of poly(butylene adipate--terephthalate) (PBAT) and polylactide (PLA) have attracted the attention of academia and industry as a sustainable material. Unfortunately, this combination results in problems related to poor miscibility on the molecular level. This study mainly aims to determine the influence of molecular weights on the miscibility of PBAT/PLA blends.

Prediction of the Miscibility of PBAT/PLA Blends.

Designing polymer structures and polymer blends opens opportunities to improve the performance of plastics. Blending poly(butylene adipate-co-terephthalate) (PBAT) and polylactide (PLA) is a cost-effective approach to achieve a new sustainable material with complementary properties. This study aimed to predict the theoretical miscibility of PBAT/PLA blends at the molecular level.

Effects of Postoperative Day and NR1I2 on Tacrolimus Clearance in Chinese Liver Transplant Recipients-A Population Model Approach.

We aimed to explore the new biomarkers influencing tacrolimus in vivo behavior in Chinese liver transplant recipients. A total of 418 drug concentration samples of 41 liver transplant patients were collected for modeling. A population pharmacokinetic model was developed using the nonlinear mixed-effects modeling approach.

Floating quick response code based on structural black color with the characteristic of privacy protection.

Since the printing quick response (QR) code can be easily produced and duplicated as a potential tool for cybercriminals, QR code security has been a hotly debated issue across globe. Here we demonstrate a floating QR code device based on the moiré principle which has the advantage of displaying an appealing three-dimensional (3D) effect and privacy protection. In the imaging system, the microlens array (MLA) contributes to efficiently sampling the multiple elemental images and the metal-coated nanostructure yields patterned structural black color with a high pattern resolution (>12, 500 dpi).

A Systematic Review and Meta-Analysis of Risk Factors Associated with Severity and Death in COVID-19 Patients.

This meta-analysis aims to screen the risk factors for severe illness and death and provide help for early clinical treatment of the new coronavirus (COVID-19). Based on a comprehensive search of PubMed, Embase, and Web of Science databases, we included studies that explored the cause and risk factors for severe illness and death in COVID-19 patients. We evaluated the strength of this relationship using odds ratios (ORs) with 95% confidence intervals (CIs).

Frequency and Patterns of Prescribing Antihypertensive Agents in Outpatient Kidney Transplant Recipients Among Six Cities in China from 2011 to 2018.

Purpose: Antihypertensive agents are frequently prescribed in kidney transplant recipients (KTRs). However, the frequency and patterns of prescribing antihypertensive agents remain uncharacterized in KTRs in China. Therefore, this investigation was carried out.

Antipsychotic use and Risk of Venous Thromboembolism: A Meta-Analysis.

Objective: This study aimed to evaluate the association between antipsychotic drugs (APs) and the risk of venous thromboembolism (VTE).

Methods: We searched Pubmed, Embase, and the Cochrane Library from inception to August 15, 2019 for case-control studies and cohort studies that explored the association between APs and VTE. Two researchers independently screened the literature, extracted the data and evaluated the bias risk included in the study.

Uncompatibilized PBAT/PLA Blends: Manufacturability, Miscibility and Properties.

Polymer blends of poly(butylene adipate-co-terephthalate) (PBAT) and polylactide (PLA) have been drawn attention due to the application potential as packaging or agricultural films. This study aims to determine the manufacturability, miscibility and mechanical properties of uncompatibilized PBAT/PLA blends prepared using different techniques. First, PBAT and PLA are melt-blended in a wide range of ratios from 90/10 to 10/90.

Microbiota Regulates Dentine Mineralisation and Differentiation of Dental Pulp Stem Cells.

Objective: To investigate the role of microbiota in dentine formation and the characteristics of dental pulp stem cells (DPSCs) in mouse incisors.

Methods: The influence of microbiota on dentine was detected via microcomputed tomography (microCT), microhardness testing and haematoxylin-eosin (HE) staining in incisors from germ-free (GF), specific pathogen-free (SPF) and conventionalised (ConvD) mice. Cell Counting Kit-8 (CCK-8) assay, alizarin red staining and expression of dentine sialophosphoprotein (DSPP), alkaline phosphatase (ALP) and bone sialoprotein (BSP) via real-time polymerase chain reaction (PCR) were used to evaluate the biological characteristics of DPSCs derived from mice of different microbiota status.

Association between Thiopurines Use and Pregnancy Outcomes in Female Patients with Inflammatory Bowel Disease: A Meta-Analysis.

Background: Conflicting data exist regarding the influence of thiopurines exposure on adverse pregnancy outcomes in female patients with inflammatory bowel disease (IBD).

Objective: The aim of this study was to provide an up-to-date and comprehensive assessment of the safety of thiopurines in pregnant IBD women.

Methods: All relevant articles reporting pregnancy outcomes in women with IBD received thiopurines during pregnancy were identified from the databases (PubMed, Embase, Cochrane Library, and ClinicalTrials.

Pharmacokinetic and Pharmacodynamic Analysis of Critically Ill Patients Undergoing Continuous Renal Replacement Therapy With Imipenem.

Purpose: This study explores factors that affect behavior in critically ill patients receiving continuous renal replacement therapy (CRRT) with imipenem and provides dosing regimens for these patients.

Methods: A prospective, open-label study was conducted in a clinical setting. Both blood and effluent samples were collected pairwise at the scheduled time points.

Efficacy and Safety of Ticagrelor Compared to Clopidogrel in Patients Undergoing Percutaneous Coronary Intervention: A Meta-Analysis.

Background: The Platelet Inhibition and Patient Outcomes (PLATO) study found that ticagrelor plus aspirin (TA) was more effective than clopidogrel plus aspirin (CA), without an increase in the risk of massive bleeding in patients undergoing percutaneous coronary intervention (PCI). Data from other studies indicate that the conclusion is controversial with the results obtained by PLATO.

Aim: To investigate the efficacy and safety of TA, compared with CA, in patients with acute coronary syndrome (ACS) after PCI.

Highly linearly polarized light emission from flexible organic light-emitting devices capitalized on integrated ultrathin metal-dielectric nanograting.

Although there have been tremendous achievements ever since the first work on an organic electroluminescent (EL) device that emitted polarized light, the development of flexible polarized emission organic light-emitting devices (OLEDs) is not without hurdles, and the challenge towards real-world applications still requires tremendous effort. In this paper, we proposed highly linearly polarized light-emission from flexible green OLEDs capitalized on integrated ultrathin metal-dielectric nanograting. The acquired polarized device with meticulously optimized geometric parameters yields an angle-invariant average extinction ratio beyond 20.

Dynamic effect in the moiré magnifier by using the weak domain transformation.

The design of an image with dynamic effect usually adopts an interlacing strategy, but it suffers from the crosstalk between the neighboring images. Here, by introduction of the weak domain transformation to the micro pattern array (MPA), striking motion effects are realized with no crosstalk. A complete theoretical model based on both the moiré and fix point theorem is developed for interpretation of the kinetics.

Flexible graphical black structural color with high angular tolerance featuring subwavelength nickel cylinder array pixels.

Black structural color has attracted particular interest due to its attractive applications in various fields. Until now, however, the reported graphical black structural color (GBSC) devices are mainly realized by means of electron beam lithography or focused ion beam technology, inevitably suffering from the obstacles of high production cost and time-consuming processing. Moreover, the limited and small area of the GBSC constitutes another issue for real applications and little attention has been devoted to flexible GBSC because of the limitations of this manufacturing approach.

Pharmacokinetic interaction of Forsythia suspensa extract and azithromycin injection after single and co-intravenous administration in rats.

Azithromycin and Chinese medicine forsythia are often used together to treat pediatric mycoplasma infections in China. We aimed to investigate the pharmacokinetic interaction of Forsythia suspensa extract and azithromycin after single and co-intravenous administration in rats. Male Sprague-Dawley rats received single (Forsythia suspensa extract or azithromycin) treatment or co-administration of Forsythia suspensa extract and azithromycin.