Transcriptomic and metabolomic reveals silicon enhances adaptation of rice under dry cultivation by improving flavonoid biosynthesis, osmoregulation, and photosynthesis.

Dry cultivation is a new rice crop mode used to alleviate water shortage and develop water-saving agriculture. There is obvious genetic difference compared with drought-tolerant rice. Silicon (Si) plays an important role in plant adaptation to adverse environmental conditions and can significantly improve the drought tolerance and yield of rice.

Advanced maternal age impairs spatial learning capacity in young adult mouse offspring.

Effects of maternal aging on the offspring cognitive function remain controversial in population-based investigations, and information available in animal studies is very limited. We investigated the impact of a delayed first natural pregnancy on pregnancy outcomes in the mouse model. Spatial learning capacity in young adult mouse offspring was observed by step-down passive avoidance task and Morris water maze (MWM).

[Tetramethoxystilbene, a selective CYP1B1 inhibitor, suppresses adipogenesis of C3H10T1/2 pluripotent stem cells].

Objective: To investigate the inhibitory effects of tetramethoxystilbene, a selective CYP1B1 inhibitor, on adipogenic differentiation of C3H10T1/2 multi-potent mesenchymal cells.

Methods: In vitro cultured C3H10T1/2 cells at full confluence were induced by adipogenic agents (10 µg/ml insulin, 2 µmol/L dexamethasone and 0.5 mmol/L 3-isobutyl-1-methylxanthine) and exposed simultaneously to TMS at the final concentrations of 1.

Association between alcohol consumption and risk of cardiovascular disease and all-cause mortality in patients with hypertension: a meta-analysis of prospective cohort studies.

Objective: To conduct a meta-analysis summarizing the risk of cardiovascular disease (CVD) and all-cause mortality (ACM) in relation to alcohol consumption in patients with hypertension, focusing on clarifying dose-response associations.

Patients And Methods: PubMed and EMBASE were searched for eligible prospective cohort studies from December 3, 1949, through January 18, 2014. The semi-parameter method and dose-response analysis were used.

Fuzheng Qingjie recipe induces apoptosis in HepG2 cells via P38 MAPK activation and the mitochondria-dependent apoptotic pathway.

Fuzheng Qingjie (FZQJ) recipe is a polyherbal Chinese medicine capable of suppressing tumor growth and is used as an adjuvant therapy for various types of cancer. However, its anticancer mechanisms are yet to be fully elucidated. In the present study, we explored whether p38 mitogen-activated protein kinase (MAPK) was involved in FZQJ-mediated mitochondria-dependent apoptosis in human hepatocellular carcinoma cells.

Determinants of metabolic syndrome in Chinese schoolchildren.

The objective of this study was to identify the potential risk factors of metabolic syndrome (MetS) among Chinese schoolchildren. A cross-sectional study among 624 children (357 boys and 267 girls, aged 9.6 ± 0.

[Effects of preconditioning of wufu jingfang on ischemia/reperfusion injury induced apoptosis in rats].

Objective: To observe the protective effect of Wufu Jingfang (WJ, containing Aconitum carmichaeli Debx, Radix Aconiti Lateralis Preparatae, Rhizoma Pinelliae, and snakegourd fruit) on myocardial ischemia-reperfusion injury (I/R) of rats, thus exploring the feasibility of recipes containing eighteen incompatible pairs for specific pathological conditions.

Methods: Fifty male Wistar rats were randomly divided into five groups, i.e.

Physical Activity and Lung Function Growth in a Cohort of Chinese School Children: A Prospective Study.

Backgrounds/objectives: Evidence on the association between physical activity and lung function in children is sparse. The aim of this study was to evaluate children's lung function growth in relation to their physical activity level in Chinese children.

Methods: A total of 1713 school children aged 9.

4-Benzyl-3,5-dimethyl-1H-pyrazole.

In the title mol-ecule, C(12)H(14)N(2), the dihedral angle between the pyrazole and phenyl ring mean planes is 78.65 (19)°. In the crystal, mol-ecules are linked by N-H⋯N hydrogen bonds into chains along [010].

Relationship of body fat and cardiorespiratory fitness with cardiovascular risk in Chinese children.

Unlabelled: BACKGROUNDS/OBJECTIVES: Cardiorespiratory fitness (CRF) and body fat play an important role in elevated risk for cardiovascular disease (CVD). However, the combined effects of CRF and obesity on metabolic health in Chinese children are unclear. The purpose of this study was to investigate the independent and combined associations between body fat, CRF, and CVD risk in Chinese schoolchildren.

Pin1 and PKMzeta sequentially control dendritic protein synthesis.

Some forms of learning and memory and their electrophysiologic correlate, long-term potentiation (LTP), require dendritic translation. We demonstrate that Pin1 (protein interacting with NIMA 1), a peptidyl-prolyl isomerase, is present in dendritic spines and shafts and inhibits protein synthesis induced by glutamatergic signaling. Pin1 suppression increased dendritic translation, possibly through eukaryotic translation initiation factor 4E (eIF4E) and eIF4E binding proteins 1 and 2 (4E-BP1/2).

Tetra-kis(3,5-dimethyl-1H-pyrazole-κN)(nitrato-κO,O')cadmium(II) nitrate.

The title compound, [Cd(NO(3))(C(5)H(8)N(2))(4)]NO(3), was prepared by reaction of cadmium nitrate and 3,5-dimethyl-pyrazole in ethanol solution. The Cd atom adopts a distorted cis-CdO(2)N(4) octa-hedral geometry involving four dimethylpyrazole molecules and one bidentate nitrate anion. The mol-ecular structure and packing are stabilized by N-H⋯O and C-H⋯O inter- and intra-molecular hydrogen-bonding inter-actions.

N-(1H-1,2,3-Benzotriazol-1-ylmeth-yl)phthalimide.

THE TITLE COMPOUND [SYSTEMATIC NAME: 2-(1H-1,2,3-benzotriazol-1-ylmeth-yl)isoindole-1,3-dione], C(15)H(10)N(4)O(2), was prepared by the reaction of 1H-benzotriazole and 2-bromo-methyl-isoindole-1,3-dione. The benzotriazole and isoindole units are almost planar and make a dihedral angle of 70.2 (1)° (mean planes include C and N atoms).

N-(Imidazol-1-ylmeth-yl)phthalimide.

THE TITLE COMPOUND [SYSTEMATIC NAME: 2-(imidazol-1-ylmeth-yl)isoindole-1,3-dione], C(12)H(9)N(3)O(2), was prepared by reaction of N-(bromo-meth-yl)phthalimide and imidazole in chloro-form solution. The crystal structure is stabilized by weak inter-molecular C-H⋯π inter-actions and inter-molecular π-π inter-actions with centroid-centroid distances in the range 3.6469 (8)-3.

N-[(3,5-Dimethyl-pyrazol-1-yl)meth-yl]phthalimide.

The title compound {systematic name: 2-[(3,5-dimenthylpyrazol-1-yl)meth-yl]isoindole-1,3-dione}, C(14)H(13)N(3)O(2), was prepared by reaction of N-(bromo-meth-yl)phthalimide and 3,5-dimethyl-pyrazole in chloro-form solution. The mol-ecular structure and packing are stabilized by intra-molecular C-H⋯O hydrogen-bonding and C-H⋯π inter-actions.

[Effects of pyrethroids on the activity of gamma-aminobutyric acid transferase in rat brain].

Objective: To study the effects of pyrethroids on the activity of gamma-aminobutyric acid transferase (GABAT) in rat brain.

Method: The coupled enzyme ultraviolet spectrophotography was applied to observe the effects of deltamethrin (DM) and permethrin (PM) on the activities of GABAT in rat cerebral cortex, hippocampus, corpus striatum and cerebellum in vitro and in vivo.

Results: In vitro, DM and PM had no significant effects on the activities of GABAT in rat cerebral cortex, hippocampus, corpus striatum and cerebellum at the final concentration of 10(-9) - 10(-4) mol/L.

[Effects of deltamethrin on cell survival rate and intracellular free Ca2+ concentration in primary cultured astrocytes of rat].

Objective: To study the effects of deltamethrin (DM) on cell survival rate and intracellular Ca(2+) ([Ca(2+)]i) concentration in primary cultured astrocytes of rat.

Methods: The cell survival rate was measured by Typan Blue assay; the intracellular [Ca(2+)]i concentration was determined by the fluorescent Ca(2+) indicator Fura-2/AM.

Results: The survival rate of astrocytes was decreased to 91.

[Brain-derived neurotrophic factor mRNA expressions in rat brain induced by short-term in vivo exposure to deltamethrin].

Objective: To elucidate the mechanism of damage on central nervous system (CNS) caused by deltamethrin (DM).

Methods: The mRNA and protein expressions of brain-derived neurotrophic factor (BDNF) in the cerebral cortex and hippocampus of the rats exposed to DM were measured by retro-transcription-polymerase chain reaction (RT-PCR), dot blot, flow cytometry analysis and immunohistochemistry.

Results: After exposure to DM at high-dose (DM1, 25.