Synopsis of recent research by authors named "Su Min Lim"
- Su Min Lim's recent research primarily focuses on the molecular mechanisms underlying neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS), examining the roles of microRNAs, proteins involved in nucleocytoplasmic transport, and alterations in cellular processes like proteostasis and ribostasis.
- Notable findings include the identification of TRIB2 as a druggable target for ALS motor neurons through miRNA profiling, and the significant impact of impaired nucleocytoplasmic transport due to interactions between FUS and Nup62.
- Additionally, Lim's work addresses the clinical implications of genetic variants in annexin A11 and explores therapeutic strategies that modulate GSTO activity to counteract neurotoxicity in ALS models, highlighting the potential for targeted interventions.
