Publications by authors named "Su Min He"
Vitiligo is an acquired pigmentary disorder characterized by loss of epidermal melanocytes. A strong association at a single nucleotide polymorphism (SNP) rs11966200 within MHC region had been identified in a recent genome-wide association study of generalized vitiligo in Chinese Han population. This study aims to investigate the relationships between SNP rs11966200 and the clinical features of generalized vitiligo in Chinese Han population.
View Article and Find Full Text PDFPsoriasis is a common inflammatory skin disease with genetic components of both immune system and the epidermis. PSOR1 locus (6q21) has been strongly associated with psoriasis; however, it is difficult to identify additional independent association due to strong linkage disequilibrium in the MHC region. We performed stepwise regression analyses of more than 3,000 SNPs in the MHC region genotyped using Human 610-Quad (Illumina) in 1,139 cases with psoriasis and 1,132 controls of Han Chinese population to search for additional independent association.
View Article and Find Full Text PDFGenome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population.
Nat Genet
June 2011
Article Synopsis
- Atopic dermatitis is a long-lasting inflammatory skin condition influenced by both genetics and the environment.
- A study involved a genome-wide analysis of atopic dermatitis in a large Chinese Han population and included additional samples from Germany, leading to the identification of new genetic markers associated with the condition.
- The findings reveal new potential genetic factors that contribute to atopic dermatitis and suggest new biological pathways that could be explored for better understanding and treatment.
Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6.
J Invest Dermatol
May 2011
A multicenter meta-analysis including data from 9,389 psoriasis patients and 9,477 control subjects was performed to investigate the contribution of the deletion of genes LCE3C and LCE3B, involved in skin barrier defense, to psoriasis susceptibility in different populations. The study confirms that the deletion of LCE3C and LCE3B is a common genetic factor for susceptibility to psoriasis in the European populations (OR(Overall) = 1.21 (1.
View Article and Find Full Text PDFGenome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC.
Nat Genet
July 2010
Article Synopsis
- - We conducted a genome-wide association study for generalized vitiligo focusing on the Chinese Han population, involving over 1,100 cases and almost 1,500 controls, followed by a larger replication study in different Chinese populations.
- - Two significant genetic markers in the major histocompatibility complex (MHC) region were identified, one associated with increased risk (rs11966200) and another potentially protective (rs9468925) related to specific HLA alleles.
- - Additionally, we discovered a new risk locus at 6q27 (rs2236313) linked to three genes, contributing to a better understanding of the genetic factors involved in vitiligo.
Background: The narrow host range of Mycobacterium leprae and the fact that it is refractory to growth in culture has limited research on and the biologic understanding of leprosy. Host genetic factors are thought to influence susceptibility to infection as well as disease progression.
Methods: We performed a two-stage genomewide association study by genotyping 706 patients and 1225 controls using the Human610-Quad BeadChip (Illumina).
Keloids are benign fibroproliferative dermal tumors of unknown etiology. Some studies have suggested that human HLA status might potentiate development of keloids phenotype. No report has been published about HLA class I alleles associated with keloids in Chinese Han individuals.
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