Associations of dietary oxidative balance score with sarcopenia in adults: an NHANES-based cross-sectional study.

Background: Sarcopenia, a prevalent muscle disorder in the older adults, is characterized by accelerated loss of muscle mass and function, contributing to increased risks of falls, functional decline, and mortality. The relationship between dietary oxidative balance score (DOBS) and sarcopenia, however, remains unclear.

Methods: We conducted a cross-sectional analysis of the National Health and Nutritional Examination Survey (NHANES) 2011-2018 cohort, which included 8,240 participants, aged 47.

Exploring synergistic evolution of carbon emissions and air pollutants and spatiotemporal heterogeneity of influencing factors in Chinese cities.

The acceleration of urbanization has significantly exacerbated climate change due to excessive anthropogenic carbon emissions and air pollutants. Based on data from 281 prefecture-level cities in China between 2015 and 2021. The spatiotemporal co-evolution of urban carbon emissions and air pollutants was analyzed through map visualization and kernel density estimation, revealing non-equilibrium and heterogeneity.

Identification of hsa_circ_0076957 and miR-4512-targeted COL19A1 as regulators in clopidogrel resistance among stable coronary heart disease patients through comprehensive circRNA and miRNA analysis.

Background: Clopidogrel resistance (CR) increases the risk of atherothrombotic events. Emerging evidence suggests that circRNAs may influence pharmacodynamic responses to clopidogrel.

Methods: A total of 25 CR and 25 non-clopidogrel resistance (NCR) patients were enrolled.

PTCDet: advanced UAV imagery target detection.

Object detection in drone aerial images is challenging due to the difficulty of small object detection and complex backgrounds. To address these issues, this paper proposes an improved object detection model, perception and target capture detector (PTCDet), to increase detection accuracy and robustness in complex scenes. Specifically, the proposed multiple feature extraction attention (MFEA) module significantly enhances the ability of the model to detect small objects through multidimensional feature map augmentation.

Prospective Cohort Investigation on Physical Activity of Osteoporosis Outcomes (PAOPO) in Jidong: Objectives, Study Design, and Baseline Characteristics.

Objective: The aim of this study was to investigate the prospective association between physical activity (PA), independently or in conjunction with other contributing factors, and osteoporosis (OP) outcomes.

Methods: The Physical Activity in Osteoporosis Outcomes (PAOPO) study was a community-based cohort investigation. A structured questionnaire was used to gather the participants' sociodemographic characteristics.

A pooled mycoviral resource in a strain of Rhizoctonia solani are regulators of fungal virulence.

Rhizoctonia solani is a widespread and devastating soil-borne plant fungal pathogen that causes diseases, including rice sheath blight, which are difficult to control. Some mycoviruses are potential biocontrol agents for the control of fungal diseases. In order to investigate the factors that influence the virulence of R.

Activation of the G Protein-Coupled Bile Acid Receptor TGR5 Modulates the HCP5/miR-139-5p/DDIT4 Axis to Antagonize Cervical Cancer Progression.

A growing body of evidence indicates that the G protein-coupled bile acid receptor, TGR5, plays a critical role in multiple physiological processes ranging from metabolic disorders to cancers. However, the biological functions of TGR5 in cervical cancer (CC) have not been elucidated. Here, using knockout mice, we found that a deficiency of TGR5 leads to greater sensitivity to the progression of cervical inflammation.

MPE-YOLO: enhanced small target detection in aerial imaging.

Aerial image target detection is essential for urban planning, traffic monitoring, and disaster assessment. However, existing detection algorithms struggle with small target recognition and accuracy in complex environments. To address this issue, this paper proposes an improved model based on YOLOv8, named MPE-YOLO.

bat STING attenuates aging-related inflammation in female mice.

Bats, notable as the only flying mammals, serve as natural reservoir hosts for various highly pathogenic viruses in humans (e.g., SARS-CoV and Ebola virus).

A fatty acid elongase complex regulates cell membrane integrity and septin-dependent host infection by the rice blast fungus.

Very-long-chain fatty acids (VLCFAs) regulate biophysical properties of cell membranes to determine growth and development of eukaryotes, such as the pathogenesis of the rice blast fungus Magnaporthe oryzae. The fatty acid elongase Elo1 regulates pathogenesis of M. oryzae by modulating VLCFA biosynthesis.

Individual virome analysis reveals the general co-infection of mammal-associated viruses with SARS-related coronaviruses in bats.

Bats are the natural reservoir hosts for SARS-related coronavirus (SARSr-CoV) and other highly pathogenic microorganisms. Therefore, it is conceivable that an individual bat may harbor multiple microbes. However, there is limited knowledge on the overall co-circulation of microorganisms in bats.

Associations between blood manganese levels and sarcopenia in adults: insights from the National Health and Nutrition Examination Survey.

Background: While increasing concerns arise about the health effects of environmental pollutants, the relationship between blood manganese (Mn) and sarcopenia has yet to be fully explored in the general population.

Objective: This study aims to investigate the association between blood manganese (Mn) levels and sarcopenia in adults.

Methods: In our study, we evaluated 8,135 individuals aged 18-59 years, utilizing data from the National Health and Nutrition Examination Survey (NHANES) spanning 2011 to 2018.

Anti-pancreatic cancer activity of cassane diterpenoids isolated from the seeds of Caesalpinia sappan mediated by autophagy activation via ROS/AMPK/mTORC1 pathway.

Three undescribed cassane diterpenoids, caesalpanins D-F (1-3), and seven known ones were isolated from the seeds of Caesalpinia sappan. Structures and absolute configurations of 1-3 were elucidated based on the extensive spectroscopic analysis, single-crystal X-ray diffraction analysis, and ECD calculations. Structurally, compound 1 was the first example of 18-norcassane diterpenoid and 2 was a rare 20-norcassane diterpenoid having an unusual five-membered oxygen bridge between C-10/C-18.

Interference Suppression Algorithm Based on Short Time Fractional Fourier Transform.

Narrowband interference and wideband interference are both common jamming signals against synthetic aperture radar, which can degrade the signal severely. To suppress interference effectively, an interference suppression method based on short-time fractional Fourier transform (STFrFT) is proposed. After transforming the signal into the time-frequency domain through STFrFT, an adaptive gain coefficient is determined for the instantaneous frequency spectrum at every certain time.

Accumulation of antitumor polyketides by fermentation of Rubus delavayi Franch. with Clonostachys rogersoniana.

The aim of this work is to explore the effects of herbal medicine on secondary metabolites of microorganisms during fermentation. Clonostachys rogersoniana was found to metabolize only small amounts of polyketide glycosides rogerson B and C on fresh potatoes, but after replacing the medium to the medicinal plant Rubus delavayi Franch., the type and content of the metabolized polyketones showed significant changes.

Transcriptome-wide map of N6-methyladenosine (m6A) profiling in coronary artery disease (CAD) with clopidogrel resistance.

Background: Clopidogrel resistance profoundly increases the risk of major cardiovascular events in coronary artery disease (CAD) patients. Here, we comprehensively analyse global m6A modification alterations in clopidogrel-resistant (CR) and non-CR patients.

Methods: After RNA isolation, the RNA transcriptome expression (lncRNA, circRNA, and mRNA) was analysed via RNA-seq, and m6A peaks were identified by MeRIP-seq.

Interface engineering of heterostructured vanadium oxides for enhanced energy storage in Zinc-Ion batteries.

Rechargeable aqueous Zn-ion batteries (RAZIBs) with the merits of cost effectiveness and high safety have been rejuvenated as tantalizing energy storage systems to meet the demand for grid-scale applications. Currently, the energy storage capability of the positive electrode (cathode) holds the key for the overall performance of RAZIBs. In this work, we reveal VO, VO·12HO (HVO), and VO/HVO can be prepared via hydrothermal reaction by using different reducing agents.

In situ electron paramagnetic resonance spectroscopy using single nanodiamond sensors.

An ultimate goal of electron paramagnetic resonance (EPR) spectroscopy is to analyze molecular dynamics in place where it occurs, such as in a living cell. The nanodiamond (ND) hosting nitrogen-vacancy (NV) centers will be a promising EPR sensor to achieve this goal. However, ND-based EPR spectroscopy remains elusive, due to the challenge of controlling NV centers without well-defined orientations inside a flexible ND.

Eudesmane-type sesquiterpenoids from the aerial parts of Artemisia lavandulaefolia and their anti-pancreatic cancer activities.

Five undescribed eudesmane sesquiterpenoids, artemilavanins A-E, and one undescribed rearranged eudesmane sesquiterpenoid, artemilavanin F, were isolated from the 95% ethanol extract of the aerial parts of Artemisia lavandulaefolia DC., along with ten known compounds. The structures and configurations of undescribed compounds were mainly elucidated by spectroscopic analyses and single-crystal X-ray diffraction analysis.