Antihyperglycemic and antioxidative effects of Hydroxyethyl Methylcellulose (HEMC) and Hydroxypropyl Methylcellulose (HPMC) in mice fed with a high fat diet.

The effect of dietary feeding of hydroxyethyl methylcellulose (HEMC) and hydroxypropyl methylcellulose (HPMC) on the glucose metabolism and antioxidative status in mice under high fat diet conditions was investigated. The mice were randomly divided and given experimental diets for six weeks: normal control (NC group), high fat (HF group), and high fat supplemented with either HEMC (HF+HEMC group) or HPMC (HF+HPMC group). At the end of the experimental period, the HF group exhibited markedly higher blood glucose and insulin levels as well as a higher erythrocyte lipid peroxidation rate relative to the control group.

Hypoglycemic and antioxidative effects of hydroxyethyl methylcellulose in mice fed with high fat diet.

The effect of hydroxyethyl methylcellulose (HEMC) with different viscosities on the glucose metabolism and antioxidative defense system in high fat-fed mice was investigated. The mice were randomly divided into five dietary groups: normal control diet (NC), high fat diet (HF), and high fat diet supplemented with high viscosity (HF-HV), moderate viscosity (HF-MV), and low viscosity (HF-LV) HEMC fibers. After 6 weeks, the HF group showed a marked increase in body weight gain, body fat, blood glucose concentration, insulin level, and erythrocyte lipid peroxidation rate relative to the NC group.

Comparative evaluation of the hypolipidemic effects of hydroxyethyl methylcellulose (HEMC) and hydroxypropyl methylcellulose (HPMC) in high fat-fed mice.

The effect of hydroxyethyl methylcellulose (HEMC), in comparison with hydroxypropyl methylcellulose (HPMC), on the body weight and lipid metabolism in mice fed with high fat diet was investigated. The animals were given normal control diet (NC group), high fat diet (HF group), or high fat diet supplemented with either HEMC (HF+HEMC group) or HPMC (HF+HPMC group) for 6weeks. At the end of the experimental period, both HF+HEMC and HF+HPMC groups showed reduced body weight, body fat, plasma triglyceride and total cholesterol contents, atherogenic index and free fatty acid level, and increased HDL-cholesterol concentration relative to the HF group.