Publications by authors named "Su Hyon Kim"
CD4-independent HIV-1 variants can infect coreceptor-expressing cells lacking CD4. The envelope (Env) glycoproteins on these HIV-1 variants expose a coreceptor binding site that overlaps some CD4-induced (CD4i) epitopes. Reports have demonstrated that CD4i antibodies mediate antibody-dependent cellular cytotoxicity (ADCC).
View Article and Find Full Text PDFNanoparticles (NPs) are used commercially in health and fitness fields, but information about the toxicity and mechanisms underlying the toxic effects of NPs is still very limited. The aim of this study is to investigate the toxic effect(s) of 100 nm negatively (ZnO(AE100[-])) or positively (ZnO(AE100[+])) charged zinc oxide (ZnO) NPs administered by gavage in Sprague Dawley rats, to establish a no observed adverse effect level, and to identify target organ(s). After verification of the primary particle size, morphology, hydrodynamic size, and zeta potential of each test article, we performed a 90-day study according to Organisation for Economic Co-operation and Development test guideline 408.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated the systemic oral toxicity of 20 nm positively charged zinc oxide nanoparticles in rats over a 90-day period to identify the no-observed-adverse-effect level.
- The research involved different dosage levels (500, 250, and 125 mg/kg), with a 14-day recovery period to observe any long-term effects.
- Key findings included increased red blood cell count and decreased protein levels in higher dosages, with notable health impacts such as pancreatic cell apoptosis and stomach inflammation, suggesting a lowest-observed-adverse-effect level of 125 mg/kg for these nanoparticles.
Purpose: The widespread use of nanoparticles (NPs) in industrial and biomedical applications has prompted growing concern regarding their potential toxicity and impact on human health. This study therefore investigated the subchronic, systemic oral toxicity and no-observed-adverse-effect level (NOAEL) of 20 nm, negatively charged zinc oxide (ZnO(SM20(-))) NPs in Sprague Dawley rats for 90 days.
Methods: The high-dose NP level was set at 500 mg/kg of bodyweight, and the mid- and low-dose levels were set at 250 and 125 mg/kg, respectively.