Efficacy of Dapagliflozin in the Treatment of Type 2 Diabetes Mellitus Complicated by Coronary Heart Disease: A Meta-Analysis.

Dapagliflozin is a sodium-glucose cotransporter inhibitor that functions to lower blood sugar by promoting glucose excretion. We conducted a meta-analysis to assess the therapeutic efficacy of dapagliflozin in patients with type 2 diabetes mellitus complicated by coronary heart disease. The objective of this analysis is to provide additional clarity on dapagliflozin's effectiveness in this specific patient population.

Meta-analysis of nifedipine and enalapril combination therapy for hypertensive patients with coronary heart disease: A systematic review and meta-analysis.

Background: Numerous clinical studies have demonstrated that the therapeutic efficacy of combining nifedipine and enalapril in treating hypertension with coronary heart disease surpasses that of nifedipine as a stand-alone treatment. However, the current evidence is not yet sufficient due to limitations in the sample size, and further validation is needed. To analyze and assess the clinical impact of nifedipine combined with enalapril on hypertension complicated with coronary heart disease, and provide evidence for rational drug use in clinic.

High-resolution observation per 1.5 h revealed prominent time-dependent daily contamination variations of p-phenylenediamine (PPD) antioxidants and their quinone derivatives PPDQs in PM from central China.

p-Phenylenediamine (PPD) antioxidants and their quinone derivatives (PPDQs), as hot-spot novel contaminants in recent years, have been detected in air fine particulate matters (PM) in multiple regions. However, current research all discussed the pollution of PPDs and PPDQs based on the collected PM samples at least in one day (23.5 h).

[Spatiotemporal Characterization and Driving Factors of Fine Particulate Matter and Its Chemical Components in the Huaihe River Basin].

According to the data sets of fine particulate matter （PM） and its components in 35 cities in the Huaihe River Basin from 2015 to 2021, the temporal and spatial distribution patterns of pollutants were analyzed. The influence of meteorological factors on PM concentrations was examined using a random forest model. The original series of PM, sulfate （SO）, nitrate （NO）, ammonium salt （NH）, organic matter （OM）, and black carbon （BC） were rebuilt using KZ （Kolmogorov-Zurbenko） filtering and multiple linear regression （MLR） to quantify the effects of meteorological conditions.

[Estimation of Regional Background Ozone in Henan Province from 2019 to 2021].

Clarifying the regional transmission and local generation contributions of ozone （O） is important for controlling O pollution. To quantify the regional background and spatial-temporal variations of O, a comprehensive study was conducted using multiple methods including principal component analysis （PCA） and TCEQ, with Henan Province as a case study. Based on monitoring data from 59 national sites in Henan Province during 2019-2021, four methods were employed to estimate the regional background of O.

[Spatial-temporal Variations and Driving Factors of Surface Ozone over the Qinghai-Xizang Plateau from 2015 to 2021].

The spatial-temporal distribution pattern of surface O over the Qinghai-Xizang Plateau （QXP） was analyzed based on air quality monitoring data and meteorological data from 12 cities on the QXP from 2015 to 2021. Kolmogorov-Zurbenko （KZ） filtering was employed to separate the original O-8h series into components at different time scales. Then, multiple linear regression of meteorological variables was used to quantitatively isolate the effects of meteorology and emissions.

Long-term evolution of carbonaceous aerosols in PM during over a decade of atmospheric pollution outbreaks and control in polluted central China.

Against the backdrop of an uncertain evolution of carbonaceous aerosols in polluted areas over the long term amid air pollution control measures, this 11-year study (2011-2021) investigated fine particulate matter (PM) and carbonaceous components in polluted central China. Organic carbon (OC) and elemental carbon (EC) averaged 16.5 and 3.

Age evolution of secondary organic aerosol: Impacts of regional transport and aerosol volatility.

In this study, a revised CMAQ model incorporating source and temporal apportioning functions has been used to analyze the aging characteristics of SOA in East Asia. The results show that in the aerosol phase, the fraction of the non-volatile components typically fluctuates around 75 %-95 %, and aromatic hydrocarbon precursors contribute significantly to SOA, accounting for 45.6 %-72.

Fabrication of nitrogen-carbon mediated γ-MoN nanocomposite based electrochemical sensor for rapid and sensitive determination of antioxidant 6-PPD in the environment.

The rapid and sensitive determination of antioxidant N-(1,3-dimethylbutyl)-N'-phenyl-p-henylenediamine (6-PPD) in the environment is crucial for early intervention to prevent its adverse effects. Here, a reliable electrochemical sensor based on a N-C mediated γ-MoN nanocomposite (γ-MoN@N-C) modified carbon paste electrode (CPE) was developed and applied for selective and sensitive determination of 6-PPD. Benefiting from the superior stability and faster electron diffusion coefficient, the peak current responded to 6-PPD on the sensor linearly over a concentration range from 5 × 10 mol L to 1.

[Evaluation of Changes in PM Exposure Concentration and Health Risk for Urban Resident in Zhengzhou Based on High Spatial Resolution Grids].

In recent years, complex air pollution with the characteristic pollutant of PM has remained serious in China. Long term exposure to PM might harm residential health and can increase premature death from specific diseases. The annual average concentration of PM in Zhengzhou was much higher than the national secondary standard, which has an extremely negative impact on the health of residents.

Contributions of local emissions and regional background to summertime ozone in central China.

Source contributions and regional transport of maximum daily average 8-h (MDA8) O during a high O month (June 2019) in Henan province in central China are explored using a source-oriented Community Multiscale Air Quality (CMAQ) model. The monthly average MDA8 O exceeds ∼70 ppb in more than half of the areas and shows a clear spatial gradient, with lower O concentrations in the southwest and higher in the northeast. Significant contributions of anthropogenic emissions to monthly average MDA8 O concentrations of more than 20 ppb are predicted in the provincial capital Zhengzhou, mostly due to emissions from the transportation sector (∼50%) and in the areas in the north and northeast regions where industrial and power generation-related emissions are high.

[One-year Simulation of Air Pollution in Central China, Characteristics, Distribution, Inner Region Cross-transmission, and Pathway Research in 18 Cities].

Air pollution in Henan province is serious and is significantly impacted by pollution transmission and interactions with surrounding areas. The emission sources in 18 cities in Henan province were labeled and applied to the WRF-CMAQ traceability model for simulation in January, April, July, and October of 2017. The pollutant distribution results showed that due to the combined influence of emissions and meteorology, the concentrations of PM, NO, and SO in Henan province were the highest in winter and the lowest in summer.

[Spatiotemporal Variations in Fine Particulate Matter and the Impact of Air Quality Control in Zhengzhou].

To study the spatiotemporal variations in fine particulate matter (PM) and the impact of air quality management in autumn and winter in Zhengzhou, five sites were selected to collect PM samples from the autumn of 2017 to the winter of 2018, and the characteristics of the chemical components were analyzed. The positive matrix factorization (PMF) model was also applied to identify the sources of PM, and the effect of air quality control was evaluated to provide support for air quality control in autumn and winter in the next stage. The PM concentrations in the four seasons in Zhengzhou were ranked as winter > autumn > spring > summer.

[Health Impact Attributable to the Control of PM Pollution in China During 2013-2017].

To evaluate the health benefits brought about by air environmental treatment and determine the main drivers of health risk, we calculated the health and economic benefits attributed to PM control in Eastern and Central China from 2013 to 2017 by combining PM concentrations with a human activity enhanced exposure-response model. The relative contributions of changes in four factors related to the PM health burden were also quantified, namely total population, population aging, baseline mortality rates, and ambient exposure. The results show that the population weighted PM concentration decreased by 28.

Formation of droplet-mode secondary inorganic aerosol dominated the increased PM during both local and transport haze episodes in Zhengzhou, China.

The size distribution and formation of secondary inorganic aerosol play a key role in the increasing PM concentration. Size-segregated data including mass, number, and chemical component concentrations were obtained during a haze episode from January 12 to 23 in Zhengzhou to gain insight into the dominant factors for the growth of PM. PM levels during two local processes (LP1 and LP2) were mainly affected by the accumulation and secondary formation of local pollutants.

[Evaluation of the Reduction in PM Concentration During the National Traditional Games of Ethnic Minorities in Zhengzhou].

To evaluate the effect of the implementation of emission reduction measures and the improvement in air quality during the National Traditional Games of Ethnic Minorities in Zhengzhou, a series of online instruments were used to continuously observe air pollutants and components of PM from August 5 to September 30, 2019. Three cases, including before emission reduction (August 5-24), during emission reduction (August 25 to September 18), and after emission reduction (September 19-30), were classified by the implementation of control measures. The results show that the growing concentration of PM after the cancellation of emission abatement measures (11.

Spatiotemporal characterization and regional contributions of O and NO: An investigation of two years of monitoring data in Henan, China.

To investigate the characteristics of ground level ozone (O) for Henan Province, the ambient air quality monitoring data of 2015 and 2016 were analyzed. The result showed that the 8 h-max-O concentrations displayed a distinct seasonality, where the maximum and minimum values, averaging 140.41, 54.

Observation of chemical components of PM and secondary inorganic aerosol formation during haze and sandy haze days in Zhengzhou, China.

Mineral dust particles play an important role in the formation of secondary inorganic aerosols, which largely contribute to haze pollution in China. During this study, a haze episode (haze days) and a typical haze process mixed with sandstorm (sandy haze days) were observed in Zhengzhou with a series of high-time-resolution monitoring instruments from November 22 to December 8, 2018. Concentrations of PM and crustal elements clearly increased in the sandy haze days.

[Characteristic of Surface Ozone and Meteorological Parameters Analysis in Anyang City].

This study uses the national ambient air quality station data of Anyang City from 2014 to 2017 to analyze the characteristics and variation rules of ozone (O) in different functional zones (urban, suburban, and industrial), and also studies meteorological influencing factors and potential source distributions of O pollution. The results showed that the O concentration in Anyang increased significantly between 2014 and 2017, whereby pollution started to advance from 2015 and the earliest occurrence of an O pollution episode was in April 2017. The 90 percentile and average concentrations of O in the industrial zone increased at faster rates (average annual growth of 16.

Chemical characteristics and source apportionment of PM between heavily polluted days and other days in Zhengzhou, China.

PM samples were collected in Zhengzhou during 3years of observation, and chemical characteristics and source contribution were analyzed. Approximately 96% of the daily PM concentrations and annual average values exceeded the Chinese National Ambient Air Quality Daily and Annual Standards, indicating serious PM pollution. The average concentration of water-soluble inorganic ions was 2.

Gender impacts on the correlations between nonalcoholic fatty liver disease and hypertension in a Chinese population aged 45-60 y.

Unlabelled: No previous study has reported the association between nonalcoholic fatty liver disease (NAFLD) and the risk of hypertension in the Chinese population. Therefore, the aim of this study was to evaluate the relationship between NAFLD and hypertension in a middle-aged Chinese population. The study subject was (a group of) 1006 Chinese adults aged 45-60 y in Shandong Province who participated in the Weifang Nutrition and Health Survey (2014-2015).

Atorvastatin Treatment for Atrial Fibrillation Reduces Serum High-Sensitivity C-Reactive Protein Levels.

We investigated whether serum hs-CRP levels predict the efficacy of atrial fibrillation (AF) treated with atorvastatin. Bibliographic databases were exhaustively searched for studies relevant to the research topic. Newcastle-Ottawa Scale (NOS) criteria, combined with the Quality Assessment of Diagnostic Accuracy Studies (QUADAS), were applied for study quality assessment.

Transforming growth factor β-interacting factor-induced malignant progression of hepatocellular carcinoma cells depends on superoxide production from Nox4.

Hepatocellular carcinoma (HCC) is one of the most deadly malignancies worldwide because of its high recurrence rate, high metastatic potential, and resistance to drugs. Elucidation of the mechanisms underlying malignancy in HCC is needed to improve diagnosis, therapy, and prognosis. Previously, we showed that transforming growth factor β-interacting factor (TGIF) antagonizes arsenic trioxide-induced apoptosis of HepG2 cells and is associated with poor prognosis and progression of urothelial carcinoma in patients after radical nephroureterectomy.

Involvement of TG-interacting factor in microglial activation during experimental traumatic brain injury.

Traumatic brain injury (TBI) is a complex injury involving several physiological alterations, potentially leading to neurological impairment. Previous mouse studies using high-density oligonucleotide array analysis have confirmed the upregulation of transforming growth-interacting factor (TGIF) mRNA in TBI. TGIF is a transcriptional corepressor of transforming growth factor beta (TGF-β) signaling which plays a protective role in TBI.

Effects of acute mechanical stretch on the expression of mechanosensitive potassium channel TREK-1 in rat left ventricle.

To explore the role of mechanosensitive potassium channel TREK-1, Western blot analysis was used to investigate the expression changes of TREK-1 in left ventricle in acute mechanically stretched heart. Forty Wistar rats were randomly divided into 8 groups (n=5 in each group), subject to single Langendorff perfusion for 0, 30, 60, 120 min and acute mechanical stretch for 0, 30, 60, 120 min respectively. With Langendorff apparatus, an acute mechanically stretched heart model was established.