Perioral Rejuvenation: Lip Lifts, Corner of Mouth Lifts, and Vermillion Advancements.

Perioral rejuvenation is a critical component in the comprehensive approach to the aging face. The perioral region-comprising the lips, philtrum, and areas surrounding the oral commissures-plays a significant role in an individual's perceived age, attractiveness, and emotional expressions. However, the perioral region is often the "forgotten area" and has the potential to undermine the success of otherwise outstanding rejuvenation surgeries.

Content Analysis of Three-Dimensional Model Technologies and Applications for Construction: Current Trends and Future Directions.

The proliferation of digital technologies is substantially transforming inspection methodologies for construction activities. Although the implementation of a three-dimensional (3D) model has emerged as an advantageous, feasible inspection application, the selection of the most suitable 3D models is challenging due to multiple technology options. The primary objectives of this study were to investigate current trends and identify future technologies for 3D models in the construction industry.

Probabilistic Method to Fuse Artificial Intelligence-Generated Underground Utility Mapping.

Utility as-built plans, which typically provide information about underground utilities' position and spatial locations, are known to comprise inaccuracies. Over the years, the reliance on utility investigations using an array of sensing equipment has increased in an attempt to resolve utility as-built inaccuracies and mitigate the high rate of accidental underground utility strikes during excavation activities. Adapting data fusion into utility engineering and investigation practices has been shown to be effective in generating information with improved accuracy.

Review of Artificial Intelligence Applications for Virtual Sensing of Underground Utilities.

Accurately identifying the location and depth of buried utility assets became a considerable challenge in the construction industry, for which accidental strikes can cause important economic losses and safety concerns. While the collection of as-built utility locations is becoming more accurate, there still exists an important need to be capable of accurately detecting buried utilities in order to eliminate risks associated with digging. Current practices typically involve the use of trained agents to survey and detect underground utilities at locations of interest, which is a costly and time-consuming process.

Assessing Technology Implementation Success for Highway Construction and Asset Management.

The increasing demand for safe, reliable, and higher-quality infrastructure systems has led to more complex transportation construction and maintenance projects. This, coupled with the declining staff levels at many transportation agencies, requires a more comprehensive evaluation of technology implementation to compensate for these challenges. With a focus on effective technology implementation, this research goes beyond simply evaluating technologies to investigate technology implementation with personnel and policies at departments of transportation (DOTs).

The Effectiveness of a Teen Outreach Pregnancy Prevention Program: Results From Youth After-School Clubs.

Background: Teen pregnancy continues to burden families, communities, and society. Programs continue to educate and impower youth and young adults to make positive behavioral decisions.

Methods: We evaluated a program aimed at high-risk youth in after-school programs.

A Novel Artificial Intelligence-Powered Emotional Intelligence and Mindfulness App (Ajivar) for the College Student Population During the COVID-19 Pandemic: Quantitative Questionnaire Study.

Background: Emotional intelligence (EI) and mindfulness can impact the level of anxiety and depression that an individual experiences. These symptoms have been exacerbated among college students during the COVID-19 pandemic. Ajivar is an app that utilizes artificial intelligence (AI) and machine learning to deliver personalized mindfulness and EI training.

Hypophosphorylation of the RB protein in S and G2 as well as G1 during growth arrest.

The RB tumor suppressor protein is a cell cycle regulator, where hypophosphorylated RB is associated with G1/0 arrest and its cyclin-dependent phosphorylation in G1 allows progression from G1 to S. The present report shows that in human leukemia cells induced to undergo growth arrest with sodium butyrate or DMSO, hypophosphorylation of the RB protein is not G1 restricted and also occurs in S and G2/M cells as well as in G1 cells when growth is inhibited. While all of the RB protein in G1/0 cells is hypophosphorylated, residual cells in S and G2 have significant detectable amounts of hypophosphorylated RB as well as still hyperphosphorylated RB protein.

An RXR-selective analog attenuates the RAR alpha-selective analog-induced differentiation and non-G1-restricted growth arrest of NB4 cells.

NB4, a human acute promyelocytic leukemia cell line expressing the promyelocyte-retinoic acid receptor alpha (PML-RAR alpha) hybrid protein was treated with RAR- and retinoid X receptor (RXR)-selective analogs to determine their effects on cell proliferation, retinoblastoma (RB) tumor-suppressor protein phosphorylation, and differentiation. An RAR- or just RAR alpha-selective analog alone induced similar cell population growth arrest, cell cycle arrest without restriction to G1, hypophosphorylation of RB, and myelomonocytic cell surface differentiation marker expression (CD11b). In addition, an RAR alpha antagonist could inhibit the effects of the RAR alpha agonist completely.

Increasing c-FMS (CSF-1 receptor) expression decreases retinoic acid concentration needed to cause cell differentiation and retinoblastoma protein hypophosphorylation.

Increasing the expression of c-FMS (colony-stimulating factor 1 receptor) by introduction of a transgene reduced the concentration of retinoic acid or 1,25-dihydroxy vitamin D3 needed to cause myeloid or monocytic cell differentiation and hypophosphorylation of the retinoblastoma tumor suppressor protein (RB) typically associated with cell cycle G0 arrest and differentiation of HL-60 human myelo-monoblastic precursor cells. The data are consistent with a model in which signals originating with retinoic acid and c-FMS integrate to cause differentiation, RB hypophosphorylation, and G0 arrest. Furthermore, these two signals can compensate for each other.

FMS (CSF-1 receptor) prolongs cell cycle and promotes retinoic acid-induced hypophosphorylation of retinoblastoma protein, G1 arrest, and cell differentiation.

The effect of the CSF-1 receptor, cFMS, on the phosphorylation of the retinoblastoma (RB) tumor suppressor protein and on the cell cycle and cell differentiation was analyzed in a cultured promyelocytic leukemia cell capable of induced myelomonocytic differentiation. A series of cFMS-transfected HL-60 sublines with progressively higher cell surface FMS expression was derived by flow cytometric cell sorting. Overexpression of FMS increased the duration of the cell cycle, prolonging all cell cycle phases especially S phase, which doubled.

Autonomic dysreflexia revisited.

Autonomic dysreflexia (AD) is a clinical phenomenon that affects patients with spinal cord injury (SCI) above the major sympathetic outflow tract. The lesion is most often at or above the T-6 level. Any noxious stimuli below this level initiate reflex sympathetic activity resulting in life threatening hypertension uncontrollable by the feedback parasympathetic activity.

Optical hit-miss morphological transform.

We present an optical correlator implementation of the morphological hit-miss transform. This provides improved recognition of objects in clutter compared with standard optical pattern-recognition correlator techniques. The hit-miss transform is modified to use rank-order filtering since this gives better performance in noise and clutter.