Automatic segmentation of cardiac structures can change the way we evaluate dose limits for radiotherapy in the left breast.

Purpose: Radiotherapy is a crucial part of breast cancer treatment. Precision in dose assessment is essential to minimize side effects. Traditionally, anatomical structures are delineated manually, a time-consuming process subject to variability.

The feasibility of a visuo-cognitive training intervention using a mobile application and exercise with stroboscopic glasses in Parkinson's: Findings from a pilot randomised controlled trial.

Background: There is currently no pharmacological treatment for visuo-cognitive impairments in Parkinson's disease. Alternative strategies are needed to address these non-motor symptoms given their impact on quality of life. Novel technologies have potential to deliver multimodal rehabilitation of visuo-cognitive dysfunction, but more research is required to determine their feasibility in Parkinson's.

Self-Directed Skills Laboratories Increase Emergency Medicine Physician Confidence in High-Acuity, Low-Opportunity Procedures.

Introduction: The critical role of emergency physicians in military settings underscores the necessity for a broad and proficient skill set, especially in life-saving procedures such as thoracostomies, endotracheal intubations, and cricothyrotomies, to maintain combat readiness. The current peacetime phase, however, presents challenges in maintaining these skills because of decreased exposure to high-acuity medical scenarios. This decrease in exposure jeopardizes skills retention among military emergency medicine physicians, highlighted by studies showing a significant decline in performance over time because of reduced practice.

FDG PET/CT in Cutaneous Involvement of Plasmablastic Plasma Cell Myeloma.

Extraosseous manifestations are found in less than 5% of patients with multiple myeloma. They can arise in any tissue, and their presence has been associated with more aggressive disease. We present FDG PET/CT findings of immunoglobulin A κ multiple myeloma with innumerable hypermetabolic right lower extremity lesions of cutaneous and subcutaneous involvement of plasmablastic plasma cell myeloma in a 44-year-old man.

Critical Design Considerations for Longer-Term Wear and Comfort of On-Body Medical Devices.

The commercialization of a growing number of wearable devices has been enabled within recent years due to the availability of miniaturized sensor modalities, the development of new materials, and the scalability of flexible electronics. With the increase in resource shortages within healthcare, there is a demand to translate wearable devices from the commercial consumer stand-point to the medical field. Clinical-grade signal quality, wearability, and comfort all need to be tailored to a wearable design.

Validity and reliability of running gait measurement with the ViMove2 system.

Running biomechanics have traditionally been analysed in laboratory settings, but this may not reflect natural running gait. Wearable technology has the potential to enable precise monitoring of running gait beyond the laboratory. This study aimed to evaluate the analytical validity and intra-session reliability of temporal running gait outcomes measured by the ViMove2 wearable system in healthy adults.

Patient-completed online "follow-up form" to assess continuation of anti-CGRP(r) antibody therapy in patients with chronic migraine: A pilot project.

Background: The introduction of new drugs that target the Calcitonin Gene-Related Peptide (CGRP) system has provided significant hope for patients with otherwise treatment-resistant migraine, but also resulted in significant capacity issues at the point of delivery, as patients require follow-up at certain timepoints.

Aim: Pilot a patient-completed "follow-up form" (FuF) to replace direct patient contact at the time of 1-year treatment review in patients receiving anti-CGRP (receptor (r)) antibody therapy for chronic migraine.

Methods: Patients with chronic migraine already receiving anti-CGRP(r) antibody therapy and due for 1-year review were contacted by telephone and recruited into the project.

Glucose deprivation impairs hypoxia-inducible factor-1α synthesis.

Hypoxia-inducible factors (HIFs) are key transcriptional mediators of the hypoxic response and are implicated in oncogenesis. HIFα is regulated by a well-characterized, oxygen-dependent degradation pathway involving the von Hippel Lindau (VHL) tumor suppressor protein. However, comparatively little is known about HIFα regulation at the translational level, particularly under cellular stress.

Implementing universal maternal depression screening in Head Start: A convergent mixed methods study.

Aims: Implementing maternal depression screening in child-serving programs can help ensure that more mothers receive mental health services. This study examined the implementation of universal maternal depression screening in community-based Head Start programs.

Methods: Quantitative and qualitative data were merged in a convergent mixed method design to assess four domains from the RE-AIM implementation science framework (Reach, Adoption, Implementation, and Maintenance).

Group Interpersonal Psychotherapy for minoritized Head Start mothers with depressive symptoms: A mixed method study.

This study explores minoritized mothers' experiences in group interpersonal psychotherapy (IPT-G) and relates their experiences to treatment outcomes. Quantitative and qualitative data were gathered from 26 Latinx and Black mothers who participated in IPT-G. Mothers were divided into three groups: (1) not depressed at follow-up, (2) depressed at follow-up, and (3) those with subclinical symptoms throughout the intervention, and similarities and differences across groups were examined.

Digital measurement of mobility in pulmonary arterial hypertension: A structured review of an emerging area.

This review examined literature that has examined mobility in pulmonary arterial hypertension (PAH) using digital technology. Specifically, the review focussed on: (a) digital mobility measurement in PAH; (b) commonly reported mobility outcomes in PAH; (c) PAH specific impact on mobility outcomes; and (d) recommendations concerning protocols for mobility measurement in PAH. PubMed, Scopus, and Medline databases were searched.

Activation of the NLRP1B inflammasome by caspase-8.

Cleavage of the innate immune receptor NLRP1B by various microbial proteases causes the proteasomal degradation of its N-terminal fragment and the subsequent release of a C-terminal fragment that forms an inflammasome. We reported previously that metabolic stress caused by intracellular bacteria triggers NLRP1B activation, but the mechanism by which this occurs was not elucidated. Here we demonstrate that TLR4 signaling in metabolically stressed macrophages promotes the formation of a TRIF/RIPK1/caspase-8 complex.

Better understanding fall risk: AI-based computer vision for contextual gait assessment.

Contemporary research to better understand free-living fall risk assessment in Parkinson's disease (PD) often relies on the use of wearable inertial-based measurement units (IMUs) to quantify useful temporal and spatial gait characteristics (e.g., step time, step length).

Using Video Technology and AI within Parkinson's Disease Free-Living Fall Risk Assessment.

Falls are a major concern for people with Parkinson's disease (PwPD), but accurately assessing real-world fall risk beyond the clinic is challenging. Contemporary technologies could enable the capture of objective and high-resolution data to better inform fall risk through measurement of everyday factors (e.g.

The Time Course of Changes in Prefrontal Cortex Activity During Walking in People With Parkinson's Disease.

Background: Walking abnormalities in people with Parkinson's disease (PD) are characterized by a shift in locomotor control from healthy automaticity to compensatory, executive control, mainly located in the prefrontal cortex (PFC). Although PFC activity during walking increases in people with PD, the time course of PFC activity during walking and its relationship to clinical or gait characteristics is unknown.

Objective: To identify the time course of PFC activity during walking in people with PD.

Enhancing fall risk assessment: instrumenting vision with deep learning during walks.

Background: Falls are common in a range of clinical cohorts, where routine risk assessment often comprises subjective visual observation only. Typically, observational assessment involves evaluation of an individual's gait during scripted walking protocols within a lab to identify deficits that potentially increase fall risk, but subtle deficits may not be (readily) observable. Therefore, objective approaches (e.

Hippocampal-dependent navigation in head-fixed mice using a floating real-world environment.

Head-fixation of mice enables high-resolution monitoring of neuronal activity coupled with precise control of environmental stimuli. Virtual reality can be used to emulate the visual experience of movement during head fixation, but a low inertia floating real-world environment (mobile homecage, MHC) has the potential to engage more sensory modalities and provide a richer experimental environment for complex behavioral tasks. However, it is not known whether mice react to this adapted environment in a similar manner to real environments, or whether the MHC can be used to implement validated, maze-based behavioral tasks.

iVOMS: Instrumented Vestibular / Ocular motor screen in healthy controls and mild traumatic brain injury.

Objective Vestibular/ocular deficits occur with mild traumatic brain injury (mTBI). The vestibular/ocular motor screening (VOMS) tool is used to assess individuals post-mTBI, which primarily relies upon subjective self-reported symptoms. Instrumenting the VOMS (iVOMS) with technology may allow for more objective assessment post-mTBI, which reflects actual task performance.

Sympathetic structural and electrophysiological remodeling in a rabbit model of reperfused myocardial infarction.

Unlabelled: Chondroitin sulfate proteoglycans (CSPGs) inhibit sympathetic reinnervation in rodent hearts post myocardial infarction (MI), causing regional hypo-innervation that is associated with supersensitivity of β-adrenergic receptors and increased arrhythmia susceptibility. To investigate the role of CSPGs and hypo-innervation in the heart of larger mammals, we used a rabbit model of reperfused MI and tested electrophysiological responses to sympathetic nerve stimulation (SNS). Innervated hearts from MI and sham rabbits were optically mapped using voltage and Ca -sensitive dyes.

The Trauma Recovery Clinic: A Stepped Collaborative Care Model for Trauma Surgery Patients to Address Health Disparities.

The Trauma Recovery Clinic (TRC) was developed to meet the psychiatric, psychological, and psychosocial needs of traumatically injured patients following discharge from a level-I trauma center. The objective of this study is to demonstrate the efficacy of the TRC as an application of the stepped collaborative care model in order to address health disparities. Patients with a history of inpatient treatment for a physically traumatic injury at this level-I trauma center were approached and enrolled at initial TRC outpatient appointments.

Digital wearable insole-based identification of knee arthropathies and gait signatures using machine learning.

Gait is impaired in musculoskeletal conditions, such as knee arthropathy. Gait analysis is used in clinical practice to inform diagnosis and monitor disease progression or intervention response. However, clinical gait analysis relies on subjective visual observation of walking as objective gait analysis has not been possible within clinical settings due to the expensive equipment, large-scale facilities, and highly trained staff required.