Gene Mutation Hereditary Diffuse Gastric Cancer Outcomes: Analysis of a Large Cohort, Systematic Review of Endoscopic Surveillance, and Secondary Cancer Risk Postulation.

Hereditary diffuse gastric cancer (HDGC) is a rare signet-ring cell adenocarcinoma (SRCC) linked to (E-cadherin) inactivating germline mutations, and increasingly other gene mutations. Female mutation carriers have additional risk of lobular breast cancer. Risk management includes prophylactic total gastrectomy (PTG).