Perioperative research into memory (PRiMe), part 2: Adult burns intensive care patients show altered structure and function of the default mode network.

Background: Long-term cognitive impairment (LTCI) is experienced by up to two thirds of patients discharged from burns intensive care units (BICUs), however little is known about its neurobiological basis. This study investigated if patients previously admitted to BICU showed structural and functional MRI changes of the Default Mode Network (DMN).

Methods: Fifteen patients previously admitted to BICU with a significant burns injury, and 15 matched volunteers, underwent structural and functional MRI scans.

High daily caffeine intake is associated with lower propofol requirements for anesthetic induction.

Background And Aims: There is significant interindividual variation in the dose of propofol required for anesthetic induction. Factors dictating this are poorly described, but understanding them would be useful for anesthetic drug dosing. It has been shown in rats and recently in humans that caffeine administration accelerates recovery from anesthesia, but no study has assessed the effect on anesthetic induction.

Peer-led live research demonstrations: challenging medical student misconceptions about research.

Modern health care provision is now fundamentally evidence based, meaning competency in academic medicine is integral to medical training. The Integrated Academic Training pathway provides focussed training in this area at a postgraduate level but no such provision exists at an undergraduate level. A number of peer-led academic societies have emerged across the UK to provide education and support for undergraduates but there is little evidence about the type of peer-led interventions that are effective.

Brain Connectivity Dissociates Responsiveness from Drug Exposure during Propofol-Induced Transitions of Consciousness.

Accurately measuring the neural correlates of consciousness is a grand challenge for neuroscience. Despite theoretical advances, developing reliable brain measures to track the loss of reportable consciousness during sedation is hampered by significant individual variability in susceptibility to anaesthetics. We addressed this challenge using high-density electroencephalography to characterise changes in brain networks during propofol sedation.

A systematic review of structural and functional MRI differences between psychotic and nonpsychotic depression.

Background: Psychotic depression is widely accepted as a specific subtype of unipolar major depression. Magnetic resonance imaging studies have begun to investigate the neurobiological changes that differentiate this subtype of major depression from non-psychotic depression. Any differences may eventually be useful in aiding diagnosis patients for whom there is diagnostic uncertainty.