C8ORF37 Is Required for Photoreceptor Outer Segment Disc Morphogenesis by Maintaining Outer Segment Membrane Protein Homeostasis.

is a causative gene for three different clinical forms of incurable retinal degeneration. However, the completely unknown function of limits our understanding of the pathogenicity of mutations. Here, we performed a comprehensive phenotypic characterization of a KO mouse line, generated using CRISPR/Cas9 technology.