Publications by authors named "Stuart Glenn Coupland"
Photopic negative response using a handheld mini-ganzfeld stimulator in healthy adults: normative values, intra- and inter-session variability.
Adriana Berezovsky Rustum Karanjia Arthur Gustavo Fernandes Gabriel Izan Santos Botelho Tatiane Luana Novele Bueno Stuart Glenn Coupland
Doc Ophthalmol
April 2021
Purpose: To determine normative values, intra- and inter-session variability for a range of parameters derived from the photopic negative response (PhNR) using a handheld mini-Ganzfeld stimulator in healthy normal adults.
Methods: Light-adapted flash full-field electroretinograms (ERGs) were recorded from healthy individuals with no visual complaints, visual acuity equal to or better than 0.0 logMAR (20/20 Snellen), and negative family history for visual diseases.
Article Synopsis
- The photopic negative response (PhNR) is a specific indicator of retinal ganglion cell activity, which is important for assessing patients with Leber's hereditary optic neuropathy (LHON), a condition that can complicate standard vision tests due to lost visual acuity.!* -
- In this study, ERG recordings were taken from individuals with a specific LHON-related mutation, and the PhNR was analyzed using automated software and manual review to exclude errors from movement.!* -
- Results showed that PhNR amplitude significantly decreased in LHON patients compared to carriers and controls, indicating potential early RGC dysfunction in carriers, thus making PhNR a promising measure for future clinical research in LHON treatment.*