Comparison of red cell and whole blood volume as performed using both chromium-51-tagged red cells and iodine-125-tagged albumin and using I-131-tagged albumin and extrapolated red cell volume.

Background: Our facility's current blood volume measurement protocol has involved separate measurement of plasma and red cell volumes. The purpose of this study is to determine whether measurement with a recently FDA-approved, one-compartment semiautomated system provides similar accuracy.

Methods: Blood volume measurement was performed on 27 volunteers using our current protocol followed immediately by semiautomated plasma volume measurement and red cell volume calculation with a recently available system (BVA-100).