Trends and predictors of laparoscopic compared with open emergent inguinal hernia repair.

Background: Laparoscopic emergent inguinal hernia repair remains controversial despite studies suggesting it is safe and feasible. Variables associated with laparoscopic compared with open emergent inguinal hernia repair are currently not well described. This study aims to investigate patient characteristics and risk factors associated with laparoscopic emergent inguinal hernia repair.

Safety of redo sleeve gastrectomy as a primary revisional procedure.

Background: Insufficient weight loss after primary laparoscopic sleeve gastrectomy (LSG) occasionally requires revisional surgery. A few single-institution studies have examined the safety of redo LSG (RSG) and have shown mixed results.

Objectives: The aim of this study was to evaluate the safety of RSG compared with LSG over a period of 30 days.

Assessing the Accuracy of Responses by the Language Model ChatGPT to Questions Regarding Bariatric Surgery.

Purpose: ChatGPT is a large language model trained on a large dataset covering a broad range of topics, including the medical literature. We aim to examine its accuracy and reproducibility in answering patient questions regarding bariatric surgery.

Materials And Methods: Questions were gathered from nationally regarded professional societies and health institutions as well as Facebook support groups.

Lower Rates of Unplanned Conversion to Open in Robotic Approach to Esophagectomy for Cancer.

Background: Minimally invasive approaches to esophagectomy have gained popularity worldwide; however, unplanned conversion to an open approach is not uncommon. This study sought to investigate risk factors associated with converting to an open approach and to evaluate outcomes following conversion.

Methods: Patients undergoing minimally invasive esophagectomy (MIE) for cancer were identified using the 2016-2019 Procedure Targeted NSQIP Database.

Benefits of Adjuvant Medical Weight Loss Intervention in Setting of Weight Regain and Inadequate Weight Loss After Weight Loss Surgery.

Background: Currently, there is no nationally accepted protocol for addressing weight regain or inadequate weight loss after MBS.

Objectives: To devise, implement, and evaluate a protocol targeting weight regain or inadequate weight loss in MBS patients at our institution.

Setting: Vanderbilt University Medical Center, Nashville, TN, United States.

Comparison of short- and long-term postoperative occurrences after robotic single-incision cholecystectomy versus multiport laparoscopic cholecystectomy.

Background: Long-term outcomes of SIRC are not well established. Furthermore, SIRC is only now being considered more frequently for patients with independent risk factors for PSH, such as obesity. As such, the paucity of data on longer-term post-surgical outcomes of SIRC is particularly notable as it pertains to obese patients.

Modified Cabrol Shunt for Atrioventricular Groove Rupture After Mitral Valve Replacement.

Rupture of the atrioventricular (AV) groove is the Achilles' heel of mitral valve replacement, and it has been associated with high rates of mortality. Here, we report successful management of a type 1 AV groove disruption using a modified Cabrol shunt to the right atrium in a patient with a severely calcified mitral annulus.

Streptococcal Pharyngitis and Appendicitis in Children.

Background: Several pathologies, including pharyngitis, are associated with abdominal pain that can mimic appendicitis. We sought to further understand the link between appendicitis-like symptoms and streptococcal (strep) pharyngitis.

Methods: All patients undergoing ultrasound imaging for appendicitis in our emergency department during 2013 were reviewed (n = 1572).

MicroRNA-mRNA interactions in a murine model of hyperoxia-induced bronchopulmonary dysplasia.

Background: Bronchopulmonary dysplasia is a chronic lung disease of premature neonates characterized by arrested pulmonary alveolar development. There is increasing evidence that microRNAs (miRNAs) regulate translation of messenger RNAs (mRNAs) during lung organogenesis. The potential role of miRNAs in the pathogenesis of BPD is unclear.

Effectiveness of dabigatran etexilate for thromboprophylaxis of mechanical heart valves.

Objective: Warfarin reduces risk of stroke in patients with mechanical heart valves but increases risk of hemorrhage and is difficult to use. Dabigatran etexilate, a new oral direct thrombin inhibitor, is safe and effective in reducing risk of stroke among patients with atrial fibrillation. No data exist in the setting of mechanical heart valves.

Design of selective thrombin inhibitors based on the (R)-Phe-Pro-Arg sequence.

Potent and selective inhibitors of thrombin were sought based on the (R)-Phe-Pro-Arg sequence. The objective was to generate similar binding interactions to those achieved by potent competitive inhibitors of the argatroban type, so eliminating the need for covalent interaction with the catalytic serine function, as utilized by aldehyde and boronic acid type inhibitors. Improving the S(1) subsite interaction by substitution of arginine with a 4-alkoxybenzamidine residue provided potent lead 2 (K(i) = 0.