Novel transcriptional responses to heat revealed by turning up the heat at night.

The circadian clock controls many molecular activities, impacting experimental interpretation. We quantify the genome-wide effects of time-of-day on the heat-shock response and the effects of "diurnal bias" in stress experiments. Heat stress has significant adverse effects on plant productivity worldwide.

Chronic musculoskeletal pain and function improve with a plant-based diet.

Background: Chronic musculoskeletal pain, often debilitating, affects all genders, ethnicities, and age groups. Research suggests consumption of a plant-based diet may improve the status of persons with chronic pain. A diet rich in fruits, vegetables and whole grains has been shown to reduce chronic pain and disability associated with musculoskeletal conditions.

A New EHR Training Curriculum and Assessment for Pediatric Residents.

Background Conventional classroom Electronic Health Record (EHR) training is often insufficient for new EHR users. Studies suggest that enhanced training with a hands-on approach and closely supported clinical use is beneficial. Objectives Our goals were to develop an enhanced EHR learning curriculum for Post Graduate Year 1 (PGY1) residents and measure changes in EHR skill proficiency, efficiency, and self-efficacy.

Practice patterns of primary care providers and urologists for use of medical expulsion therapy.

Purpose: Alpha-blockers and calcium channel blockers have shown promise for medical expulsion therapy (MET) of distal ureteral calculi < 1 cm in size. Although MET has been discussed in urology for some time, little has been written about MET in the emergency medicine and primary care literature. We sought to evaluate current practice patterns of MET among urologists, emergency medicine physicians, other primary care providers, and frontline military care providers.

Targeted gene delivery to CD117-expressing cells in vivo with lentiviral vectors co-displaying stem cell factor and a fusogenic molecule.

The development of a lentiviral system to deliver genes to specific cell types could improve the safety and the efficacy of gene delivery. Previously, we have developed an efficient method to target lentivectors to specific cells via an antibody-antigen interaction in vitro and in vivo. We report herein a targeted lentivector that harnesses the natural ligand-receptor recognition mechanism for targeted modification of c-KIT receptor-expressing cells.

Comparative decline of professional school graduates' performance on the Examination for Professional Practice in Psychology.

The discrepancy between traditional (Boulder Model) and professional school (Vail Model) clinical psychology graduate programs on the Examination for Professional Practice in Psychology (EPPP) was greater using 1997-2005 data than in an earlier study using 1988-1995 data. The relative decline of the performance of professional school graduates on the EPPP was attributed in part to the increase of 31.1% in number of listed professional schools over the last decade, in particular, because those schools have lower academic standards.

Transporting children with orthopaedic conditions and surgeries.

While motor vehicle crashes remain one of the leading causes of death and injury to children, proper and consistent use of child safety seats and safety belts can greatly improve children's chances of survival in motor vehicle crashes. Children with orthopaedic conditions and children after orthopaedic surgery, however, may be restricted to specialized child restraint options that are capable of providing proper fit and safe travel for a period of time after the procedure. To assure proper selection and avoid secondary injury, parents and health care professionals need to be aware of best practices for transporting children postoperatively and of restraint options that exist for children with orthopaedic conditions.

Child safety seat use for infants with Pierre Robin sequence.

Objective: To determine what child restraints would accommodate infants with Pierre Robin sequence who often require special attention in motor vehicle travel since microagnathia usually requires a prone position to keep the infant's airway open.

Research Design: Dynamic testing and clinical trial.

Setting: An Indiana children's hospital providing primary and tertiary care.

A survey of transportation services for children with disabilities.

Although many students with disabilities are transported daily in school vehicles, few state guidelines address special transportation needs. This study collected information from two states on the types of vehicles and safety restraints used, and the problems encountered by public schools, community agencies, and rehabilitation centers that transport people with disabilities from birth to 21 years of age. The information collected, together with a review of research on special needs transportation, contributed toward development of state regulations for school buses used to transport special education students.

Transportation resources for pediatric orthopaedic clients.

Pediatric orthopaedic surgery clients may be unable to safely, comfortably, and affordably use child safety seats (car seats) for a variety of reasons. This article describes commercially available child safety seats suitable for transporting pediatric orthopaedic surgery clients. Discussed are those children with cerebral palsy, spina bifida, hip dislocations, arthrogryposis, scoliosis, and osteogenesis imperfecta.

Safe transportation for infants with severe hydrocephalus.

Attention must be devoted to proper positioning and selection of an appropriate child restraint system for infants with severe hydrocephalus to reduce the risk of potential injury during motor vehicle travel. Due to the infant's head size, parents may fear the head and neck will fall forward, or they may encounter difficulty positioning the head forward-facing in a child safety seat. Two case studies illustrate how a commercially available infant-only care seat can be modified to accommodate the infant with severe hydrocephalus and how use of a car bed restraint can meet positioning needs of these infants.

Establishing special needs car seat loan program.

Car seat loan and rental programs have provided many families with low-cost access to child restraints. When an infant or child is unable to be accommodated in a standard car seat or seat belt owing to physical or medical problems, parents of these children have few, if any available resources. The establishment and operation of a loan program at the Indiana University School of Medicine for children who are medically fragile is reviewed in this article.

Transporting children in body casts.

Automotive restraint systems for children in body or hip spica casts, who cannot be accommodated by conventional child restraints or seat belts, were investigated. A car bed restraint and a harness vest restraint were subjected to simulated 30-miles/h crash tests to assess their effectiveness. The successful systems were then tried by patients and their families and found to be convenient as well.

Safe transportation for children with disabilities.

Few guidelines are available on providing safe transportation for children who cannot use conventional auto restraints. This article discusses the misuse of restraints and reviews several modified car seats and other restraints that have been tested and that meet safety standards.

Learned helplessness in the cockroach (Periplaneta americana).

For 3 consecutive days cockroaches (Periplaneta americana) were exposed to either escapable, inescapable, or no shock in an escape task. Twenty-four hours later they were tested in a shuttlebox escape task. There were reliable differences between escapable and inescapable animals and between inescapable and control animals in both escape latencies and the number of failures to escape.

Automotive restraint systems for premature infants.

Automotive restraint systems suitable for use with low birth weight infants were crash tested using a small infant dummy developed for the study. Conventional semiupright rear-facing child restraints were tested, as well as a new car bed restraint that may be advantageous for infants who are medically fragile and who must remain in a prone or supine position. This car bed can be adapted to accommodate a very small infant effectively.

Misuse of car safety seats.

Correct use of car seats for small children is essential to prevent serious injuries and death from automotive accidents. Failure to use a car seat properly can contribute to serious injury or death of a child. A case study in which misuse of a car seat occurred is reported.

Safety seat use for children with hip dislocation.

Treatment of children with congenitally dislocated hips requires that an infant be placed into a plaster spica cast for a duration of 3 to 12 months. Because the use of a safety seat is difficult, if not impossible, for children fitted with a brace or spica cast, a solution for safe transportation was developed. A Century child restraint model 100 or the Century model 300 was selected as appropriate for modification.