Behavioral impacts of a mixture of six pesticides on rats.

Pesticides can potentially contribute to the development of numerous neurodegenerative diseases. This study evaluates the effects of a six-pesticide mixture at doses around the no-observed-adverse-effectlevels (0 × NOAEL, control) and 0.25, 1 and 5 × NOAEL on behavior of Wistar rats.

Hypoxia as pathogenic factor affecting the eye tissues: The selective apoptotic damage of the conjunctiva and anterior epithelium of the cornea.

The effect of acute hypoxia on the occurrence of apoptosis in eye cells in rats placed in a pressure chamber was studied. Selective primary lesion of cells of the conjunctiva and the anterior corneal epithelium was found. A possible role of the simulated hypoxic conditions in the dry eye syndrome pathogenesis, which is accompanied by primary lesion of cells in the anterior eye surface tissues is discussed.

[Carotenoids of the human eye in prenatal and early postnatal development].

The review deals with the role of carotenoids in the formation of the structural and functional differentiation of the macula--the area of the highest visual acuity of the human retina. The review also presents the data on detection of carotenoids (lutein) in the vitreous body of the human eye during its prenatal development and discusses their possible role in the development of the retina, particularly in relation to differentiation of the macular area. Macular dystrophy has been considered till recently as senile pathology.

[Comparative evaluation of the antioxidant activity of para-aminobenzoic acid and emoxipin in the cornea and crystalline lens (an experimental study)].

Antioxidant effect of paraaminobenzoic acid (PABA) in the retina upon different routes of its administration has been revealed previously. In this study we investigated the antioxidant effect of PABA in the cornea and lens of rats after its parabulbar injection. Antioxidant activity of PABA was compared to that of emoxipin.

[Antithrombotic activity of para-aminobenzoic acid].

Mechanisms of the anticoagulant activity of p-aminobenzoic acid (PABA) were studied. The specific antithrombin activity of PABA is aIIa = 7.00 +/- 0.

[Regulation of the mitotic activity in the rat cornea in response to protective and therapeutic effects of para-aminobenzoic acid in experiments with roentgen radiation].

The protective and therapeutic action of p-aminobenzoic acid (PABA), at doses effective in interferon induction (Akberova et al., 1999), was studied on the rat cornea in the experiments with X-irradiation (5 Gy). PABA at 10 mg/kg preserved the postradiation mitotic activity at the level of irradiated control, while at 1.

[Para-aminobenzoic acid--an interferon inducer].

Para-aminobenzoic acid (PABA) was shown to be an early type interferon inductor. PABA (10 micrograms/ml) induced interferon production in vitro in the cells of human peripheral blood and in vivo in albino mice (10 mg/kg). The results of the study suggested that PABA was able to induce production of interferon-alpha/beta in various immunocyte populations.

[The antithrombotic activity of para-aminobenzoic acid in experimental thrombosis].

It was shown for the first time that p-aminobenzoic acid (PABA), in addition to the previously described fibrinolytic activity, exerts the properties of a direct anticoagulant both in vitro and in vivo. PABA not only displays antithrombin activity, but also inhibits activated factor X and, upon intravenous injection to rats and rabbits, shows the antithrombotic effect. The most pronounced antithrombotic affect was observed at a dose of 1.

[Study of interferon-inducing activity of para-aminobenzoic acid injected subconjunctivally in rabbits].

Para-aminobenzoic acid (PABA) is an early interferon inductor. The present study assesses the interferon-inducing activity of PABA (0.007 and 0.

[Comparative assessment of antioxidant activity of para-aminobenzoic acid and emoxipin in retina].

Effect of para-aminobenzoic acid (PABA) on lipid peroxidation (LPO) in rat and guinea pig retina exposed to hypoxic hypoxia is studied. PABA was injected intraperitoneally and parabulbarly before and after hypoxic exposure. Antioxidant activities of PABA and emoxipin were compared.

[Effect of para-aminobenzoic acid on the development of rat embryos when applied to pregnant females].

In order to study the effects of para-aminobenzoic acid (PABA) on embryonic development, the pregnant rats were injected intraperitoneally daily with 0.3% PABA at 5 mg/kg (0.3 ml/200 g): in group 2 during the preimplantation period (days 1-6 of pregnancy), in group 3 during the period of organogenesis (days 6-16), and in group 4 during days 1-16.

[Para-aminobenzoic acid in therapy of experimental keratitis caused by herpes simplex virus in rabbits: the therapeutic effect and decrease of infectious titer].

Para-aminobenzoic acid (PABA) in low concentrations exerted an antiherpetic effect with a good therapeutic result in rabbits with experimental keratoconjunctivitis caused by herpes simplex virus (HSV) (experimental group). In group 2 (control) 0.9% NaCl solution was used as placebo.

[Action of para-aminobenzoic acid and its combination with acyclovir in herpetic infection].

The effect of para-amino benzoic acid (PABA) on the virus of Herpes simplex (VHS-1, strain L2) was studied and it was shown to be active in vitro and in vivo. The action of PABA was virucidal in the culture of the cell-free virus-containing material. It lowered the death rate of the laboratory mice with experimental herpetic encephalitis (intraperitoneal contamination) at the average by 40 per cent and increased the mean life-span of the animals significantly decreasing the virus titre in the mouse brain.

[The effect of para-aminobenzoic acid on the level of proliferative activity in the regenerating cornea of adult rats (a radioautographic study)].

[3H]-Thymidine radioautography showed that 0.005% p-aminobensoic acid (PABA) solution applied three times per day on penetrating wounds in central part of the adult rat cornea selectively stimulates proliferative activity of corneal stroma keratoblasts. In control rats, a curve showing changes in index of labeled nuclei in corneal stroma had two peaks, on the second and sixth day after injury (about 5 and 3%, respectively), whereas in animals receiving PABA treatment it had a single peak on the second day (about 12%).

[The activity of melanin-aggregating hormones in the blood and eyes in the early postnatal development of rats].

The activity of melanin-aggregating hormones (MAH) in the blood serum and homogenates of the eyes in four strains of rats was determined using the method of bioassay on dermal melanophores of tadpoles (Rana temporaria). This test-system is sensitive to melatonin at concentration of 25.1 mg/ml and higher.