Publications by authors named "Strel'tsova N"

Aim: The study was aimed at comparatively assessing the dynamics of the parameters of the microcirculatory bed of the skin after endovascular revascularization of the lower limb in patients suffering from intermittent claudication (IC) with and without type 2 diabetes mellitus (DM).

Patients And Methods: Microcirculation (MC) of the skin of lower extremities was examined in 88 male patients presenting with IC and without DM (Group One) and in 28 male patients with IC and DM (Group Two). 30 patients from Group One and 21 patients from Group Two were subjected to endovascular revascularization of lower limbs.

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Aim: To evaluate changes in the microcirculation (MC) of hypertensive patients during increased blood pressure (BP).

Subjects And Methods: The investigation enrolled 66 patients with grades 2-3 hypertension and 57 apparently healthy individuals. After 2-day discontinuation of antihypertensive drugs, the patients were divided into 2 groups: (1) BP < or = 140/90 mm Hg; (2) BP > or = 160/100 mm Hg.

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The aim of the work was to estimate changes of microcirculation (MC) in patients with arterial hypertension (AH) with different types of peripheral hemocirculation in response to a single intake of corinfar. The study included 45 patients (mean age 54.3 +/- 1.

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The aim of the study was to assess effect of omega-3 polyunsaturated fatty acids (PUFAs) on clinical manifestations of metabolic syndrome (MS) and microcirculation in patients with arterial hypertension (AH). 22 patients of the 32 with grade 2 AH and MC symptoms (by ATP III criteria) were given 1.5 mg of omega-3 PUFAs for 1 months.

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The study demonstrates that hypercholesterinemia in patients with coronary heart disease (CHD) is associated with functional depression of microcirculation, increase in total peripheral vascular resistance, reduction in the functional efficiency of heart and decrease in activity tolerance. After receiving a course of low-intensity infrared laser radiation treatment the patients displayed positive changes in blood lipid spectrum, which was associated with improvement in microcirculation, decrease in afterload, increase in economization of heart functioning and activity tolerance. The obtained results demonstrate that the hypolipidemic effect of laser radiation is a substantial factor in the regression of CHD manifestations.

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Paired bicycle ergometric tests were performed to study the basic features of the aerobic hemodynamic mechanism of antianginal effects of reference representatives of the major classes of antianginal drugs (AADs) (nitrosorbide, corinfar, propranolol) in 54 patients with Functional Classes II-IV angina pectoris (AP). Oxygen consumption and central hemodynamic parameters were studied during exercise. The efficiency of a single administration of the drugs was 53-62%.

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A total of 59 patients suffering from ischemic heart disease with effort angina (functional classes II-IV) entered the study. Of them, 29 patients received antianginal drugs and 10-day courses of a combination of drugs with membran-oprotective properties (MPD); 30 patients received antianginal drugs alone. Blood levels of lipid peroxidation products, lipid structure of erythrocytic membrane, exercise tolerance were studied before and after the treatment.

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Aim: To evaluate cardiodynamic changes in response to magnetolaser therapy (MLT) and these changes links with lipid shifts in cell membrane.

Material And Methods: The study enrolled 50 patients with effort angina (functional class II-III). Of them, 37 patients were exposed to 10-day courses of MLT, 13 patients were exposed to sham procedures.

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Modification of erythrocytic membrane and the trend in clinicofunctional indices were studied in 93 patients with angina of effort (FC i-IV) in the course of treatment with laser radiation (group 1) and imitation of laser radiation (group 2). In patients of group 1 the treatment resulted in stabilization of cell membrane accompanied with positive cardiodynamic changes.

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Modification of erythrocytic membrane and the trend in clinicofunctional indices were studied in 90 patients with angina of effort (FC I-IV) in the course of treatment with a combination of membranoprotective drugs (group 1), magneto-laser radiation (group 2) and imitation of laser radiation (group 3). In patients of groups 1 and 2 the treatment resulted in stabilization of cell membrane accompanied with a hypotensive effect and increased exercise tolerance due to more effective cardiac performance.

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Aim: Assessment of microcirculation in IHD patients at preclinical stage or in those with initial symptoms of cardiac failure, clarification of relationship between parameters of microcirculation and cardiodynamics.

Material And Methods: A blind cross-over trial was made to compare skin microcirculation and cardiodynamic parameters in response to a short carvedilol course and beta-blocker anaprilin in 40 patients with ischemic heart disease with angina of effort (NYHA class I-IV, ejection fraction under 45%).

Results: IHD with initial symptoms of cardiac failure had a congestion-spastic type of microcirculation defect.

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Cardiodynamic changes due to beta-blocker carvedilol and low-intensity infrared laser radiation were compared in 115 patients with ischemic heart disease (IHD). The comparison has shown a similar positive effect on heart contractility and diastolic function. This gave arguments for feasibility of laser beam usage as a neurohormonal modulator in IHD patients to reduce cardiac remodulation and prevent cardiac failure.

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50 patients with postinfarction cardiosclerosis and angina pectoris (functional class I-IV) having left ventricular ejection fraction < 45% entered a comparative cross-over trial of antianginal effectiveness of anaprilin and carvediolol (dilatrend). In 10 patients carvedilol was compared to placebo. Carvedilol is shown to demonstrate higher antianginal activity which is the highest in patients with angina pectoris of low load.

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93 patients with ischemic heart disease, 44(47.3%) of them with arterial hypertension, were exposed to laser irradiation (LI). LI was accompanied with lowering of arterial pressure, more prominent in hypertensive patients.

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Aim: To examine antioxidant and antiarrhythmic activity of carvedilol vs that of standard beta-blocker anaprilin in coronary patients with low left ventricular ejection fraction (LVEF).

Material And Methods: The cross-over trial enrolled 50 coronary male patients with LVEF under 45%. Before and after treatment with carvedilol and anaprilin, measurements were made of blood dienic conjugates and malonic dialdehyde, 24-h ECG monitoring was performed.

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In view of possible exacerbation of ischemic heart disease in laser therapy as a result of structural modification of biomembranes it is suggested to prevent secondary exacerbation by combination of laser therapy with membranoprotectors including antioxidants, lipase inhibitors, phospholipases and essential phospholipids.

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Oxygen transport and central hemodynamics were studied in 66 healthy males with different blood cholesterol levels and 24 patients with angina of effort under standard exercise test. Increased blood cholesterol was found to influence exercise energy maintenance in healthy people. Subnormal efficacy of oxygen transport system provokes intensification of cardiac activity.

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As shown by a 6-month follow-up of anginal patients exposed to a single 10-day course of infrared laser radiation, the antianginal effect of this laser treatment manifested 1 month after the end of the radiation, was registered in 80-82% of the patients and persisted after 6-month follow-up in 62.5% of the patients. The therapeutic effect was the highest in patients with severe coronary insufficiency.

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As shown by conjunctival biomicroscopy, microcirculatory picture in 176 patients with coronary heart disease (CHD) compared to that of 76 healthy controls exhibited gross changes in the terminal vascular bed. 36 CHD patients have received laser treatment. Positive trends correlating with clinical response were registered in these laser-treated patients.

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In 20 patients with exercise-induced angina, the cold test brought about activated lipid peroxidation, modified the lipid phase of a red cell membrane, which correlated with systolic changes. Following a month laser therapy, it did not cause no activation of lipid peroxidative processes, significant changes in the organization of a cell membrane lipid bilayer, or any profound cardiac performance abnormalities, which gives grounds to state that laser radiation exerts membrane-stabilizing and antistress effects. The findings suggest that laser therapy should be used in coronary heart disease patients having a functional component of coronary insufficiency.

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