Cancer incidence and exposure to 4,4'-methylene-bis-ortho-chloroaniline (MbOCA).

Aims: To monitor the occurrence of cancer in a recently defined cohort of UK workers engaged in the manufacture of polyurethane elastomers using 4,4'-methylene-bis-ortho-chloroaniline.

Methods: A cohort of 308 male production workers from seven factories have been enumerated. All employees had a minimum of 12 months employment and were first employed at one of the participating factories in the period 1973-2000.

A cohort mortality and cancer incidence survey of recent entrants (1982-91) to the UK rubber industry: findings for 1983-2004.

Aim: To monitor the occurrence of cancer in a recently defined cohort of UK rubber workers.

Methods: A cohort of 8651 male and female workers from 41 UK rubber factories has been enumerated. All employees had a minimum of 12 months employment and were first employed at one of the participating factories in the period 1982-91.

Heterobimetallic lithium alkyltriimido aluminate cages containing the [R'Al(NR)3]4- tetraanion (R' = Bu(n), Et; R = 2-OMeC6H4).

Attempted metallation of a triamidoaluminane gives a complex containing the [R'Al(NR)3]4- anion whose formal tetranegative charge is the highest charge observed crystallographically for a simple mononuclear imido main group anion system.

Cohort mortality and cancer incidence survey of recent entrants (1982-91) to the United Kingdom rubber industry: preliminary findings.

Objectives: To monitor the occurrence of stomach and lung cancer in a newly defined cohort of United Kingdom rubber workers and to report findings for other cancers in an early period of follow up.

Methods: A prospective cohort of 9031 male and female workers from 42 United Kingdom rubber factories has been enumerated. All employees had a minimum of 12 months employment and were first employed at one of the participating factories in the period 1982-91.

Mortality in the British rubber industry 1946-85.

The mortality experienced by a cohort of 36,691 rubber workers during 1946-85 has been investigated. These workers were all male operatives first employed in any one of the 13 participating factories in 1946-60; all had worked continuously in the industry for a minimum period of one year. Compared with the general population, statistically significant excesses relating to cancer mortality were found for cancer of the pharynx (E = 20.

Buspirone--frontrunner of a new genre of anxiolytics.

Buspirone (Buspar; Bristol) marks a departure from established concepts of anxiolysis. Differing substantially both in its mode of action and in the clinical expression of its action from agents such as barbiturates and benzodiazepines, it would seem to operate chiefly via the 5-HT1A subtype of serotonin receptor. Such receptor selectivity is likely to be responsible for the novel action of this anxiolytic in that sedation and psychomotor and cognitive dysfunction are minimal, and because dependence is unlikely.

Alprazolam--a new triazolobenzodiazepine.

The advent of another benzodiazepine, alprazolam (Xanor; Upjohn), is of interest because of the antidepressant properties which this agent seems to possess. A short résumé of the pharmacology of alprazolam is presented in an attempt to provide an early perspective on its place in therapeutics.

Erythromycin--three decades later.

This article reviews some of the more recent developments relating to the clinical usage of erythromycin. The bactericidal and tissue-penetrating properties of this antibiotic are described and the suggestion that erythromycin has a very useful spectrum of activity in respiratory tract infections is supported by a variety of studies. We examine the increasing application of erythromycin in an extending number of problems such as sexually acquired disorders, a variety of diseases produced by infection with Legionella species and the enteritides associted with Campylobacter and Shigella species.